Results 91 to 100 of about 1,160,104 (280)

A Programmable Calcification Nanoplatform for Loco‐Regional Calcification‐Immune Hepatocellular Carcinoma Therapy

open access: yesAdvanced Science, EarlyView.
An in situ‐grown BP‐CaO2 nanoplatform supplies coordinated Ca2+, endogenous phosphate, and oxidative stress to convert tumor calcification from a passive endpoint into an active immune‐remodeling process. Widespread hydroxyapatite deposition is visualized by CT, while multi‐omics reveals MCOLN2 as a calcium‐responsive mediator linking biomineralization
Long Liu   +11 more
wiley   +1 more source

Newfoundland Lung Association Newsletter; Lung Association of Newfoundland and Labrador Newsletter

open access: yes, 1982
The Northern Light, Summer 1982Contents Page -- The Cross of Lorraine or Double-Barred Cross -- Obituaries -- Editorial: 1982, A Year to Remember / E. G. House -- His Hon. W. Anthony Paddon, C.M. M.D.
Newfoundland Lung Association
core  

Lung Cancer in Pulmonary Fibrosis: Tales of Epithelial Cell Plasticity [PDF]

open access: yes, 2011
Lung epithelial cells exhibit a high degree of plasticity. Alterations to lung epithelial cell function are critically involved in several chronic lung diseases such as pulmonary fibrosis.
Königshoff, M.   +2 more
core   +1 more source

Spatiotemporally Ultrasound‐Controlled Nanoparticles Reprogramming Immunostimulatory Antigen‐Presenting Cancer‐Associated Fibroblasts to Enhance Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
We developed an ultrasound‐controlled biomimetic nanoplatform, mRNA/V@M NPs, to co‐deliver CD74 mRNA and V‐9302 for fibrotic TNBC therapy. CD74 mRNA reprograms myCAFs into antigen‐presenting apCAF cells through the CD74‐MHC II pathway, while V‐9302 induces ICD and activates MHC I‐CD8+ T cell immunity.
Chen Ai   +9 more
wiley   +1 more source

The Use of Air in the Inspired Gas Mixture During Two-Lung Ventilation Delays Lung Collapse During One-Lung Ventilation [PDF]

open access: yes, 2009
BACKGROUND: Collapse of the ipsilateral lung facilitates surgical exposure during thoracic procedures. The use of different gas mixtures during two-lung ventilation (2LV) may improve or impede surgical conditions during subsequent one-lung ventilation ...
Waddell, Thomas   +7 more
core  

Reversing Temozolomide Resistance in Glioblastoma Based on Cuproptosis‐Mediated Positive Feedback Loop

open access: yesAdvanced Science, EarlyView.
To effectively reverse TMZ resistance, this work proposes a cuproptosis‐mediated positive feedback loop that integrates mitochondrial dysfunction, ATP depletion, AMPK‐p53 signaling, and glycolytic inhibition, ultimately amplifying cell death. This cuproptosis‐mediated feedback loop simultaneously disrupts multiple resistance pathways in GBM, including ...
Wenjie Feng   +9 more
wiley   +1 more source

Newfoundland Lung Association Newsletter; Lung Association of Newfoundland and Labrador Newsletter

open access: yes, 1986
The Northern Light, Campaign 1986Message from the President -- 1986 Christmas Seal Design -- Christmas Seals Being Prepared -- Newfoundlanders Complete Terms at National Level -- Meet Clyde! -- West Coast Advisory Board Planning Full Year -- Dr.
Newfoundland Lung Association
core  

Viewing the Fall of Ming China through the Lens of Climate Change: Timothy Brook: The Price of Collapse: The Little Ice Age and the Fall of Ming China. Princeton & Oxford: Princeton University Press, 2023. 256 pp. [PDF]

open access: yes
Review by Yu-lung Tseng on Timothy Brook\u27s The Price of Collapse: The Little Ice Age and the Fall of Ming China. Princeton & Oxford: Princeton University Press, 2023.Tseng Yu-lung Tseng\u27s recenziója Timothy Brook: The Price of Collapse: The ...
Tseng, Yu-lung
core   +1 more source

Monitoring of lung edema by microwave reflectometry during lung ischemia-reperfusion injury in vivo [PDF]

open access: yes, 2006
It is still unclear whether lung edema can be monitored by microwave reflectometry and whether the measured changes in lung dry matter content (DMC) are accompanied by changes in PaO(2) and in pro-to anti-inflammatory cytokine expression (IFN-gamma and ...
Metzger, R. P.   +6 more
core   +1 more source

Harmonizing Rigidity and Flexibility: Embedding COF Quantum Dots Into Extracellular Matrix Gel as Carbon Monoxide Depot for Acoustically Triggered Time‐Programmable Anti‐Infective Therapy

open access: yesAdvanced Science, EarlyView.
A rigid‑flexible integrated CO depot is engineered by embedding rigid COFQDs into a flexible ECM gel network. The rigid framework enables high‑capacity CO storage and sonodynamic bacterial killing, while the flexible ECM gel controls sustained CO release, collectively eradicating multidrug‑resistant infection and promoting scarless healing.
Baohong Sun   +13 more
wiley   +1 more source

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