Results 1 to 10 of about 4,770,227 (251)

Mitogen-activated protein kinases regulate susceptibility to ventilator-induced lung injury. [PDF]

PLoS ONE, 2008
Mechanical ventilation causes ventilator-induced lung injury in animals and humans. Mitogen-activated protein kinases have been implicated in ventilator-induced lung injury though their functional significance remains incomplete. We characterize the role
Tamás Dolinay, Wei Wu, Naftali Kaminski, Emeka Ifedigbo, A Murat Kaynar, Mária Szilasi, Simon C Watkins, Stefan W Ryter, Alexander Hoetzel, Augustine M K Choi   +9 more
doaj   +3 more sources

Nicotinamide exacerbates hypoxemia in ventilator-induced lung injury independent of neutrophil infiltration. [PDF]

PLoS ONE, 2015
BACKGROUND:Ventilator-induced lung injury is a form of acute lung injury that develops in critically ill patients on mechanical ventilation and has a high degree of mortality. Nicotinamide phosphoribosyltransferase is an enzyme that is highly upregulated
Heather D Jones, Jeena Yoo, Timothy R Crother, Pierre Kyme, Anat Ben-Shlomo, Ramtin Khalafi, Ching W Tseng, William C Parks, Moshe Arditi, George Y Liu, Kenichi Shimada   +10 more
doaj   +2 more sources

Revisiting ventilator-induced lung injury: from mechanical power to immunometabolic interaction [PDF]

Frontiers in Immunology
Ventilator-induced lung injury (VILI) occurs through the interaction of mechanical stress, immune system changes, and metabolic shifts. Models that focus mainly on pressure and volume do not fully represent this complex process.
Yuelian Luo, Zixuan Wu, Jinglei Wu, Zijian You, Yue Chen, Xinquan Wei, Yujie Liang, Jiancong Yang, Mingbo Luo, Jie Chen, Huijun Dai   +10 more
doaj   +2 more sources

Ventilator‐Induced Lung Injury: Mechanotransduction and Potential Therapeutic Targets [PDF]

MedComm
Mechanical ventilation (MV) serves as a critical intervention to maintain adequate gas exchange. Unfortunately, MV often leads to the development of ventilator‐induced lung injury (VILI).
He Ren, Ziqi Shang, Alastair G. Stewart, Ying‐xin Qi, Kai Huang   +4 more
doaj   +2 more sources

YAP activity protects against ventilator-induced lung injury [PDF]

Frontiers in Physiology
IntroductionMechanical ventilation (MV) activates inflammatory signaling pathways, leading to ventilator-induced lung injury (VILI), the activation of lung repair processes, persistent inflammatory stimulation and incomplete tissue repair leads to ...
Huan Liu, Huan Liu, Xuepeng Yang, Feng Qi, Xuan Li, Xuan Li, Yu Liu, Yu Liu, Ge Liu, Xiaojie Lin   +9 more
doaj   +2 more sources

Risk factors for ventilator-induced-lung injury develop three to five times faster after a single episode of lung injury [PDF]

Canadian Journal of Respiratory Therapy, 2023
Introduction Mechanical ventilator breaths provided to deeply sedated patients have an abnormal volume distribution, encouraging alveolar collapse in dependent regions and promoting alveolar overdistention in non-dependent regions.
*Elizabeth C. Rohrs, Thiago G. Bassi, Michelle Nicholas, Jessica Wittmann, Marlena Ornowska, Karl C. Fernandez, Matt Gani, Steven C. Reynolds   +7 more
doaj   +2 more sources

A scale-free model of acute and ventilator-induced lung injury: a network theory approach inspired by seismology [PDF]

Frontiers in Network Physiology
IntroductionAcute respiratory distress syndrome (ARDS) presents a significant clinical challenge, with ventilator-induced lung injury (VILI) being a critical complication arising from life-saving mechanical ventilation.
Drew C. Gottman, Bradford J. Smith, Bradford J. Smith   +2 more
doaj   +2 more sources

Alveolar mechanics: A new concept in respiratory monitoring

Journal of Mechanical Ventilation, 2022
A detailed understanding of respiratory mechanics during mechanical ventilation aids diagnostic accuracy and facilitates close monitoring of patient progress, allowing individualized ventilator adjustments aimed at minimizing ventilator induced lung ...
Ehab G. Daoud, Claudio Luciano Franck
doaj   +1 more source

Effects of positive end-expiratory pressure and recruitment maneuvers in a ventilator-induced injury mouse model. [PDF]

PLoS ONE, 2017
Positive-pressure mechanical ventilation is an essential therapeutic intervention, yet it causes the clinical syndrome known as ventilator-induced lung injury.
Laura A Cagle, Lisa M Franzi, Angela L Linderholm, Jerold A Last, Jason Y Adams, Richart W Harper, Nicholas J Kenyon   +6 more
doaj   +1 more source

Ventilator-induced lung injury in children

Journal of Pediatric Critical Care, 2023
Mechanical ventilation is one of the common lifesaving interventions used in the care of critically ill children admitted to the pediatric intensive care unit. However, it may induce lung inflammation that can cause or aggravates lung injury.
Suresh Kumar Angurana, K C Sudeep, Shankar Prasad   +2 more
doaj   +1 more source