Results 11 to 20 of about 4,770,227 (251)

Ventilator associated or induced lung injury. Does the name matter? Point and counterpoint

Journal of Mechanical Ventilation
The terminology used to describe lung injuries in patients receiving mechanical ventilation has significant implications for clinical practice, research, and communication among healthcare professionals.
Aurio Fajardo-Campoverdi, Ehab G. Daoud
doaj   +2 more sources

Molecular Mechanisms of Ventilator-Induced Lung Injury

Chinese Medical Journal, 2018
Objective: Mechanical ventilation (MV) has long been used as a life-sustaining approach for several decades. However, researchers realized that MV not only brings benefits to patients but also cause lung injury if used improperly, which is termed as ...
Lin Chen, Hai-Fa Xia, You Shang, Shang-Long Yao   +3 more
doaj   +2 more sources

A Biofabricated Human Acinus-on-a-Chip Unveils Mechanotransductive Drivers of Ventilator-Induced Lung Injury via Decoupling Volutrauma and Barotrauma. [PDF]

Adv Sci (Weinh)
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Lu H, Liu L, Hu Z, Fang S, Ren R, Liu S, Zhao M, Luo Z, Zhang Z, Shao W, Liu Q.   +10 more
europepmc   +2 more sources

Combined angiotensin-converting enzyme and aminopeptidase inhibition for treatment of experimental ventilator-induced lung injury in mice

Frontiers in Physiology, 2023
Introduction: Ventilator-induced lung injury (VILI) may aggravate critical illness. Although angiotensin-converting enzyme (ACE) inhibition has beneficial effects in ventilator-induced lung injury, its clinical application is impeded by concomitant ...
Xinjun Mao, Xinjun Mao, Verena Tretter, Yi Zhu, Yi Zhu, Felix Kraft, Benjamin Vigl, Marko Poglitsch, Roman Ullrich, Roman Ullrich, Dietmar Abraham, Katharina Krenn   +11 more
doaj   +1 more source

Membrane translocation of IL-33 receptor in ventilator induced lung injury. [PDF]

PLoS ONE, 2015
Ventilator-induced lung injury is associated with inflammatory mechanism and causes high mortality. The objective of this study was to discover the role of IL-33 and its ST2 receptor in acute lung injury induced by mechanical ventilator (ventilator ...
Shih-Hsing Yang, Jau-Chen Lin, Shu-Yu Wu, Kun-Lun Huang, Fang Jung, Ming-Chieh Ma, Guoo-Shyng Wang Hsu, Guey-Mei Jow   +7 more
doaj   +1 more source

The Modulation of Interferon Regulatory Factor-1 via Caspase-1-Mediated Alveolar Macrophage Pyroptosis in Ventilator-Induced Lung Injury

Mediators of Inflammation, 2022
Background. To examine the role of interferon regulatory factor-1 (IRF-1) and to explore the potential molecular mechanism in ventilator-induced lung injury. Methods.
Minhui Dai, Qian Li, Pinhua Pan
doaj   +1 more source

Role of Dual Oxidases in Ventilator-induced Lung Injury. [PDF]

, 2021
Positive-pressure ventilation results in ventilator-induced lung injury, and few therapeutic modalities have been successful at limiting the degree of injury to the lungs.
Hoehne, Sabrina, Kenyon, Nicholas, Last, Jerold, Linderholm, Angela, Franzi, Lisa, Illek, Beate, Harper, Richart, Cagle, Laura   +7 more
core   +1 more source

High bias gas flows increase lung injury in the ventilated preterm lamb. [PDF]

PLoS ONE, 2012
BACKGROUND: Mechanical ventilation of preterm babies increases survival but can also cause ventilator-induced lung injury (VILI), leading to the development of bronchopulmonary dysplasia (BPD).
Katinka P Bach, Carl A Kuschel, Stuart B Hooper, Jean Bertram, Sue McKnight, Shirley E Peachey, Valerie A Zahra, Sharon J Flecknoe, Mark H Oliver, Megan J Wallace, Frank H Bloomfield   +10 more
doaj   +1 more source

New Frontiers in Functional and Molecular Imaging of the Acutely Injured Lung: Pathophysiological Insights and Research Applications

Frontiers in Physiology, 2021
This review focuses on the advances in the understanding of the pathophysiology of ventilator-induced and acute lung injury that have been afforded by technological development of imaging methods over the last decades.
Guido Musch
doaj   +1 more source

CLEC5A is critical in Pseudomonas aeruginosa–induced NET formation and acute lung injury

JCI Insight, 2022
Pseudomonas aeruginosa is one of the most common nosocomial infections worldwide, and it frequently causes ventilator-associated acute pneumonia in immunocompromised patients. Abundant neutrophil extracellular traps (NETs) contribute to acute lung injury,
Pei-Shan Sung, Yu-Chun Peng, Shao-Ping Yang, Cheng-Hsun Chiu, Shie-Liang Hsieh   +4 more
doaj   +1 more source