Results 31 to 40 of about 4,770,227 (251)

Pre-treatment with allopurinol or uricase attenuates barrier dysfunction but not inflammation during murine ventilator-induced lung injury. [PDF]

PLoS ONE, 2012
Uric acid released from injured tissue is considered a major endogenous danger signal and local instillation of uric acid crystals induces acute lung inflammation via activation of the NLRP3 inflammasome. Ventilator-induced lung injury (VILI) is mediated
Maria T Kuipers, Hamid Aslami, Alexander P J Vlaar, Nicole P Juffermans, Anita M Tuip-de Boer, Maria A Hegeman, Geartsje Jongsma, Joris J T H Roelofs, Tom van der Poll, Marcus J Schultz, Catharina W Wieland   +10 more
doaj   +1 more source

Mechanistic and protective approach to ventilator-induced lung injury: A narrative review

Pediatric Respirology and Critical Care Medicine, 2023
Mechanical ventilation is a lifesaving tool in the management of acute hypoxemic respiratory failure and acute respiratory distress syndrome. It is a double-edged sword if not used gently and with lung protective strategies, especially in heterogeneous ...
Megha Shriram Jhunjhunwala, Anil Sachdev
doaj   +1 more source

High levels of S100A8/A9 proteins aggravate ventilator-induced lung injury via TLR4 signaling. [PDF]

PLoS ONE, 2013
BACKGROUND: Bacterial products add to mechanical ventilation in enhancing lung injury. The role of endogenous triggers of innate immunity herein is less well understood. S100A8/A9 proteins are released by phagocytes during inflammation. The present study
Maria T Kuipers, Thomas Vogl, Hamid Aslami, Geartsje Jongsma, Elske van den Berg, Alexander P J Vlaar, Joris J T H Roelofs, Nicole P Juffermans, Marcus J Schultz, Tom van der Poll, Johannes Roth, Catharina W Wieland   +11 more
doaj   +1 more source

Soluble triggering receptor on myeloid cells-1 is expressed in the course of non-infectious inflammation after traumatic lung contusion : a prospective cohort study [PDF]

, 2011
Introduction: The triggering receptor expressed on myeloid cells-1 (TREM-1) is known to be expressed during bacterial infections. We investigated whether TREM-1 is also expressed in non-infectious inflammation following traumatic lung contusion. Methods:
Geiger, Emanuel Valentin, Marzi, Ingo, Sven Sartorius, Barbara Pullmann, Tobias M Bingold, Bertram Scheller, Scheller, Bertram, Wissing, Heimo, Emanuel V Geiger, Ingo Marzi, Zacharowski, Kai, Kai Zacharowski, Heimo Wissing, Pullmann, Barbara, Bingold, Tobias Michael, Sartorius, Sven   +15 more
core   +1 more source

Benefit of broccoli extract-sulforaphane prophylaxis in ventilator-induced lung injury

Journal of Medical Sciences, 2022
Background: Owig to the extensive use of mechanical ventilation, risks of acute lung injury are significant in the intensive care unit. Broccoli extract-sulforaphane (SFN) has been investigated as bioactive polyphenol in chronic lung diseases.
Chen-Liang Tsai, Chih-Ying Changchien, Chi-Huei Chiang, Shan-Yueh Chang, Ying-Chieh Chen, Chih-Feng Chian   +5 more
doaj   +1 more source

Ventilator-induced lung injury

, 2013
The purpose of mechanical ventilation is to rest the respiratory muscles while providing adequate gas exchange. Ventilatory support proved to be indispensable during the 1952 polio epidemic in Copenhagen, decreasing mortality among patients with ...
Ranieri VM., Slutsky AS
core   +2 more sources

Strategies to prevent ventilator-associated lung injury in critically Ill patients

Indian Journal of Respiratory Care, 2018
Life-saving mechanical ventilation (MV) induces or exacerbates a range of pulmonary pathologies, collectively known as ventilator-induced lung injury if there is evidence of direct causation (i.e., in the research laboratory).
Alex Joseph, Muhammad Faisal Khan, Rajkumar Rajendram   +2 more
doaj   +1 more source

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source

Supplemental of "Expiratory energy dissipation and ventilator induced lung injury"

, 2022
Supplemental material for the paper "Expiratory energy dissipation and ventilator induced lung injury"
Mattia Busana (9469502)
core   +1 more source

Mitogen activated protein kinase activated protein kinase 2 regulates actin polymerization and vascular leak in ventilator associated lung injury. [PDF]

PLoS ONE, 2009
Mechanical ventilation, a fundamental therapy for acute lung injury, worsens pulmonary vascular permeability by exacting mechanical stress on various components of the respiratory system causing ventilator associated lung injury.
Mahendra Damarla, Emile Hasan, Adel Boueiz, Anne Le, Hyun Hae Pae, Calypso Montouchet, Todd Kolb, Tiffany Simms, Allen Myers, Usamah S Kayyali, Matthias Gaestel, Xinqi Peng, Sekhar P Reddy, Rachel Damico, Paul M Hassoun   +14 more
doaj   +1 more source