Results 91 to 100 of about 269,803 (346)

Experimental determination of the respiratory tract deposition of diesel combustion particles in patients with chronic obstructive pulmonary disease

Particle and Fibre Toxicology, 2012
Background Air pollution, mainly from combustion, is one of the leading global health risk factors. A susceptible group is the more than 200 million people worldwide suffering from chronic obstructive pulmonary disease (COPD).
Löndahl Jakob, Swietlicki Erik, Rissler Jenny, Bengtsson Agneta, Boman Christoffer, Blomberg Anders, Sandström Thomas   +6 more
doaj   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Inhalable fucoidan microparticles combining two antitubercular drugs with potential application in pulmonary tuberculosis therapy [PDF]

, 2018
The pulmonary delivery of antitubercular drugs is a promising approach to treat lung tuberculosis. This strategy not only allows targeting the infected organ instantly, it can also reduce the systemic adverse effects of the antibiotics. In light of that,
Ana Grenha, Ana Rosa da Costa, Buttini, Francesca Buttini, Ludmylla Cunha, M Faleiro, Stefaniak-Vidarsson, Susana Rodrigues   +7 more
core   +2 more sources

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Increased particle mass deposition on lung tissue due to industrial and waste-burning activities

Environment International
Understanding airborne particle mass deposition in the lungs is crucial for assessing health effects, particularly in regions with severe air pollution.
Anusmita Das, Erwin W. Karg, George A. Ferron, Jürgen Schnelle-Kreis, Anil Kumar Mandariya, Gazala Habib, Alfred Wiedensohler, Mira L. Pöhlker, Ralf Zimmermann, Ajit Ahlawat   +9 more
doaj   +1 more source

Engineering of Nebulized Metal–Phenolic Capsules for Controlled Pulmonary Deposition

Advanced Science, 2020
Particle‐based pulmonary delivery has great potential for delivering inhalable therapeutics for local or systemic applications. The design of particles with enhanced aerodynamic properties can improve lung distribution and deposition, and hence the ...
Yi Ju, Christina Cortez‐Jugo, Jingqu Chen, Ting‐Yi Wang, Andrew J. Mitchell, Evelyn Tsantikos, Nadja Bertleff‐Zieschang, Yu‐Wei Lin, Jiaying Song, Yizhe Cheng, Srinivas Mettu, Md. Arifur Rahim, Shuaijun Pan, Gyeongwon Yun, Margaret L. Hibbs, Leslie Y. Yeo, Christoph E. Hagemeyer, Frank Caruso   +17 more
doaj   +1 more source

Acute reperfusion intramyocardial hemorrhage leads to regional chronic iron deposition in the heart [PDF]

, 2013
Intramyocardial hemorrhage commonly occurs in large reperfused myocardial infarctions. However, its long-term fate remains unexplored.
Cokic, Ivan, Dharmakumar, Rohan, Friedrich, Matthias G, Kali, Avinash, Kumar, Andreas, Tang, Richard, Tsaftaris, Sotirios A.   +6 more
core   +2 more sources

A Bespoke Programmable Interpenetrating Elastomer Network Composite Laryngeal Stent for Expedited Paediatric Laryngotracheal Reconstruction

Advanced Functional Materials, EarlyView.
A programmable interpenetrating double‐network architecture, created via 3D‐TIPS printing and resin infusion, synergistically combines thermoplastic and thermosetting elastomers to balance structural rigidity and surface softness—crucial for paediatric laryngeal stents.
Elizabeth F. Maughan, Lei Wu, Dong Zhang, Linxiao Wu, Graca Ferreira Vaz Pinto Mendes, Wanqiao J. Tu, Heping Ma, Toby J. Proctor, Colin R. Butler, Thomas Kjærgaard, Mark W. Lowdell, Martin A. Birchall, Robert E. Hynds, Richard Hewitt, Wenhui Song   +14 more
wiley   +1 more source

Flow and particle deposition using an integrated CFD model of the respiratory system [PDF]

, 2011
This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece.
3rd Micro and Nano Flows Conference (MNF2011), Alexopoulos, AH, Karakosta, P, Kiparissides, C   +3 more
core  

Beam Energy Considerations for Gold Nano-Particle Enhanced Radiation Treatment [PDF]

, 2009
Purpose: A novel approach using nano technology enhanced radiation modalities is investigated. The proposed methodology uses antibodies labeled with organically inert metals with a high atomic number.
Heuvel, F. Van den, Locquet, J. P., Nuyts, S.   +2 more
core   +2 more sources