Results 71 to 80 of about 1,756,909 (330)

Biophysical model to predict lung delivery from a dual bronchodilator dry-powder inhaler

International Journal of Pharmaceutics: X, 2019
A biophysical lung model was designed to predict inhaled drug deposition in patients with obstructive airway disease, and quantitatively investigate sources of deposition variability. Different mouth-throat anatomies at varying simulated inhalation flows
Myrna B. Dolovich, Andreas Kuttler, Thomas J. Dimke, Omar S. Usmani   +3 more
doaj   +1 more source

The Protective Effects of IL-31RA Deficiency During Bleomycin-Induced Pulmonary Fibrosis

Frontiers in Immunology, 2021
Idiopathic Pulmonary Fibrosis (IPF) is a severe fibrotic lung disease characterized by excessive collagen deposition and progressive decline in lung function.
Dan J. K. Yombo, Dan J. K. Yombo, Varshini Odayar, Varshini Odayar, Nishant Gupta, Anil G. Jegga, Anil G. Jegga, Satish K. Madala, Satish K. Madala   +8 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

National Atmospheric Deposition Program 2011 Annual summary [PDF]

, 2012
is peer reviewedSubmitted by Susan Braxton (braxton@illinois.edu) on 2013-01-29T22:55:31Z No. of bitstreams: 1 2011as.pdf: 4443124 bytes, checksum: 1e2ff568a6e350fe41bba46c81de3531 (MD5)Made available in DSpace on 2013-01-29T22:55:31Z (GMT). No.
National Atmospheric Deposition Program
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Asthma control in patients receiving inhaled corticosteroid and long-acting beta2-agonist fixed combinations. A real-life study comparing dry powder inhalers and a pressurized metered dose inhaler extrafine formulation [PDF]

, 2011
Background Although patients have more problems using metered dose inhalers, clinical comparisons suggest they provide similar control to dry powder inhalers.
Eszes, Noemi, Gabriele Nicolini, Chrystyn, Henry, Eszes Noemi, György Losonczy, Noemi Eszes, Henry Chrystyn, Müller, Veronika, Gabriella Gálffy, Chrystyn Henry, Nicolini Gabriele, Gálffy Gabriella, Andrea Bizzi, Lilla Tamási, Bizzi Andrea, Tamási Lilla, Gálffy, Gabriella, Tamási, Lilla, Müller Veronika, Losonczy, György, Nicolini, Gabriele, Bizzi, Andrea, Veronika Müller, Losonczy György   +23 more
core   +2 more sources

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

FACTORS THAT AFFECT THE LUNG DEPOSITION [PDF]

International Journal of Modern Physics: Conference Series, 2013
The lung is an external organ forming the site of unwanted material or particles. In order to protect it, the airways have to be highly effective filters and if the particle deposit they need to be cleared. Inhaled particles can cause a variety of diseases. There are various factors on which the prediction of depositing particles depends, such as age,
SHWETA SANKHALA, H. S. SINGH, S. K. SINGH, GAUTAM LALWANI   +3 more
openaire   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Modeling the deposition of bioaerosols with variable size and shape in the human respiratory tract – A review

Journal of Advanced Research, 2012
The behavior of bioaerosol particles with various size and shape in the human respiratory tract was simulated by using a probabilistic model of the lung and an almost realistic mathematical approach to particle deposition.
R. Sturm
doaj   +1 more source

National Atmospheric Deposition Program 2014 Annual Summary [PDF]

, 2015
The National Atmospheric Deposition Program (NADP) provides fundamental measurements that support informed decisions on environmental issues related to precipitation and atmospheric deposition chemistry, as well as atmospheric mercury and ammonia.

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