Results 91 to 100 of about 1,756,909 (330)

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

Emission Characterization of Synthetic and Natural Candles in a Residential Environment

Atmosphere
The combustion of candles is known to emit various air pollutants, including particulate matter (PM) and volatile organic compounds (VOCs), into the air.
Dalton Crunkelton, Marcel Ilie, Dorothy Seybold, Jhy-Charm Soo, Atin Adhikari   +4 more
doaj   +1 more source

Experimental determination of the respiratory tract deposition of diesel combustion particles in patients with chronic obstructive pulmonary disease

Particle and Fibre Toxicology, 2012
Background Air pollution, mainly from combustion, is one of the leading global health risk factors. A susceptible group is the more than 200 million people worldwide suffering from chronic obstructive pulmonary disease (COPD).
Löndahl Jakob, Swietlicki Erik, Rissler Jenny, Bengtsson Agneta, Boman Christoffer, Blomberg Anders, Sandström Thomas   +6 more
doaj   +1 more source

Assessing airways deposition, physiology and pharmacokinetics of monodisperse aerosols in obstructive lung disease [PDF]

, 2016
Inhaled medication is standard therapy in asthma and COPD. However the amount of drug reaching the lung is influenced by several factors including aerosol particle size and upper airway morphology. While smaller sized aerosol particles may be transported
Kalsi, Harpal
core   +1 more source

Guanosine‐Quadruplex Hydrogels as Dynamic, Mechanically Tunable and Ion Conductive 3D Scaffolds for Cell Culture Applications

Advanced Functional Materials, EarlyView.
Versatile guanosine‐quadruplex (GQ) hydrogels are developed as dynamic biomatrices for cell culture. These scaffolds are fabricated under mild aqueous conditions, present improved stability, tunable mechanical properties within physiological ranges; fibrillar, porous microstructure, ion conductivity, and cytocompatibility.
Neha Thakur, Minye Jin, Pavel Milkin, Deepa Negi, Carla Cofiño Fabres, Hubert Gojzewski, Leonid Ionov, Alla Synytska, Andries van der Meer, Robert Passier, Julieta I. Paez   +10 more
wiley   +1 more source

Configuration‐Encoded Cell Alignment by Light‐Gated Silicon Photovoltaic Microcell Arrays

Advanced Functional Materials, EarlyView.
Light‐gated silicon photovoltaic microcells convert pulsed illumination into localized electrical cues. Arranging otherwise similar microcells into four‐lobed, six‐lobed, or circular patterns directs fibroblasts into corresponding local arrangements without wired stimulation.
Yifan Tao, Ilayda Namli, Joseph Christakiran Moses, Youdi Liu, Suihong Liu, Syed Hasan Askari Rizvi, Yasar Ozer Yilmaz, Ibrahim T. Ozbolat   +7 more
wiley   +1 more source

Increased particle mass deposition on lung tissue due to industrial and waste-burning activities

Environment International
Understanding airborne particle mass deposition in the lungs is crucial for assessing health effects, particularly in regions with severe air pollution.
Anusmita Das, Erwin W. Karg, George A. Ferron, Jürgen Schnelle-Kreis, Anil Kumar Mandariya, Gazala Habib, Alfred Wiedensohler, Mira L. Pöhlker, Ralf Zimmermann, Ajit Ahlawat   +9 more
doaj   +1 more source

Biomimetic Hybrid‐Membrane Nanoreactor for Deep‐Seated Photodynamic Immunotherapy of Hepatocellular Carcinoma via Dual Catalysis‐Enhanced ROS Amplification and cGAS‐STING Activation

Advanced Functional Materials, EarlyView.
UCNP@MnOx‐Hyp@HRM (UMHM) enables tumor targeting and accumulation. Under 808 nm NIR irradiation, PDT/CDT synergistically triggers ICD and cGAS–STING immunity for deep hepatocellular carcinoma therapy. ABSTRACT Photodynamic therapy (PDT) is promising against hepatocellular carcinoma (HCC).
Wen Li, Jianzhang Luo, Pei Lu, Dongqing Liu, Huijun Yi, Xiaoyuan Yi, Bixia Chi, Wen Chen, Qingyu Zeng, Feifei He, Liyan Wang   +10 more
wiley   +1 more source

Engineering of Nebulized Metal–Phenolic Capsules for Controlled Pulmonary Deposition

Advanced Science, 2020
Particle‐based pulmonary delivery has great potential for delivering inhalable therapeutics for local or systemic applications. The design of particles with enhanced aerodynamic properties can improve lung distribution and deposition, and hence the ...
Yi Ju, Christina Cortez‐Jugo, Jingqu Chen, Ting‐Yi Wang, Andrew J. Mitchell, Evelyn Tsantikos, Nadja Bertleff‐Zieschang, Yu‐Wei Lin, Jiaying Song, Yizhe Cheng, Srinivas Mettu, Md. Arifur Rahim, Shuaijun Pan, Gyeongwon Yun, Margaret L. Hibbs, Leslie Y. Yeo, Christoph E. Hagemeyer, Frank Caruso   +17 more
doaj   +1 more source

Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis [PDF]

, 2012
Idiopathic pulmonary fibrosis (IPF) is a fatal disease that is unresponsive to current therapies and characterized by excessive collagen deposition and subsequent fibrosis.
Bozinovski, S, O'Donoghue, R.J.J., Prêle, C.M., Ernst, M.R., Anderson, GP, Vlahos, R., Knight, DA, McKenzie, B.S., Wang, B, Jarnicki, AG, Prêle, CM, Laurent, GJ, McAnulty, R.J., Thiem, S, Lau, HL, Vlahos, R, Zhu, H.J., Richards, CD, Mutsaers, SE, Ernst, MR, Stumbles, P.A., Laurent, G.J., Knight, D.A., Thiem, S., Jarnicki, A.G., Lau, H.L., O'Donoghue, RJJ, McAnulty, RJ, Stumbles, P, Richards, C.D., Anderson, G.P., McKenzie, BS, Rose-John, S, Mutsaers, S.E., Zhu, HJ, Wang, B., Jones, J., Rose-John, S., Jones, J, Bozinovski, S.   +39 more
core   +1 more source