Results 51 to 60 of about 1,756,909 (330)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

LncRNA DACH1 protects against pulmonary fibrosis by binding to SRSF1 to suppress CTNNB1 accumulation

Acta Pharmaceutica Sinica B, 2022
Idiopathic pulmonary fibrosis (IPF) is a progressive disease with unknown etiology and limited therapeutic options. Activation of fibroblasts is a prominent feature of pulmonary fibrosis.
Jian Sun, Tongzhu Jin, Zhihui Niu, Jiayu Guo, Yingying Guo, Ruoxuan Yang, Qianqian Wang, Huiying Gao, Yuhan Zhang, Tianyu Li, Wenxin He, Zhixin Li, Wenchao Ma, Wei Su, Liangliang Li, Xingxing Fan, Hongli Shan, Haihai Liang   +17 more
doaj   +1 more source

The Effect of Heterogeneity of Lung Structure on Particle Deposition in the Rat Lung [PDF]

Toxicological Sciences, 2000
Differences in particle deposition patterns between human and rat lungs may be attributed primarily to their differences in breathing patterns and airway morphology. Heterogeneity of lung structure is expected to impact acinar particle deposition in the rat.
W, Hofmann, B, Asgharian, R, Bergmann, S, Anjilvel, F J, Miller   +4 more
openaire   +2 more sources

Modeling of Pharmaceutical Aerosol Transport in the Targeted Region of Human Lung Airways Due to External Magnetic Field

, 2021
The present study shows a symmetric third-generation lung model by considering a specific position for targeted drug delivery (see Figure 30.1a). Left lung is chosen as the targeted region for the particle transport direction and deposition, as the left ...
Ghosh, A, Rahimi-Gorji, M, Saha, SC, Das, R, Islam, MS, Ghosh, Anusmriti, Mohammad S. Islam, Mohammad Rahimi-Gorji, Rahimi Gorji, Mohammad, Suvash C. Saha, Islam, Mohammad S., Anusmriti Ghosh, Das, Raj, Saha, Suvash C., Raj Das   +14 more
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

An In Vitro–In Vivo Comparison of Two Levodopa Dry Powder Products for Inhalation: A Randomized Trial Comparing Inbrija and Levodopa Cyclops

Pharmaceutics
Background/Objectives: The pulmonary administration of levodopa enables a rapid absorption and onset of action, making it a suitable administration route for managing OFF episodes in Parkinson’s disease.
Julia M. E. Berends, Ettina J. Wimmenhove, Marcel Hoppentocht, Paul Hagedoorn, Henderik W. Frijlink, Floris Grasmeijer   +5 more
doaj   +1 more source

Altered deposition of inhaled nanoparticles in subjects with chronic obstructive pulmonary disease

BMC Pulmonary Medicine, 2018
Background Respiratory tract deposition of airborne particles is a key link to understand their health impact. Experimental data are limited for vulnerable groups such as individuals with respiratory diseases.
Jonas K F Jakobsson, H Laura Aaltonen, Hanna Nicklasson, Anders Gudmundsson, Jenny Rissler, Per Wollmer, Jakob Löndahl   +6 more
doaj   +1 more source

Aerosol drug delivery to spontaneously-breathing preterm neonates: lessons learned

Respiratory Research, 2021
Delivery of medications to preterm neonates receiving non-invasive ventilation (NIV) represents one of the most challenging scenarios for aerosol medicine.
Federico Bianco, Fabrizio Salomone, Ilaria Milesi, Xabier Murgia, Sauro Bonelli, Elena Pasini, Raffaele Dellacà, Maria Luisa Ventura, Jane Pillow   +8 more
doaj   +1 more source