Results 41 to 50 of about 1,756,909 (330)
Biological Obstacles for Identifying In Vitro-In Vivo Correlations of Orally Inhaled Formulations
Pharmaceutics, 2019 Oral inhalation of drugs is the classic therapy of obstructive lung diseases. In contrast to the oral route, the link between in vitro and in vivo findings is less well defined and predictive models and parameters for in vitro-in vivo correlations are ...
Eleonore Fröhlich
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Control of Collagen Deposition in Mammalian Lung
Experimental Biology and Medicine, 1995 This review considers the mechanisms controlling collagen deposition in mammalian lung in five different states: normal development, fibrosis, erosion, pneumonectomy, and the steady state. Deposition is the net result of positive and negative processes.
R S, Bienkowski, M G, Gotkin
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Effect of corticosteroids and long-acting ß2- agonists in a human cell culture based "in vitro" model of airway inflammation and tissue remodeling [PDF]
, 2006 Asthma and chronic obstructive pulmonary disease (COPD) are characterized by chronic airway inflammation and remodeling. In non-pathological conditions tissue homeostasis is maintained by the balance between extracellular matrix (ECM) synthesis and ...
Goulet, Stéphanie
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AtmosphereAirborne particulate matter is a major pollutant globally due to its impact on atmospheric processes and human health. Depending on their aerodynamic size, particles can penetrate the respiratory system, with ultrafine particles (UFPs) reaching the ...
Fabian L. Moreno Camacho +6 more
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KONA Powder and Particle Journal, 2017 The paper discusses essential engineering challenges related to the application of powder medicines for pulmonary delivery as inhaled aerosol. Starting from a physically based description of the complexity of aerosol dynamics inside the respiratory ...
Tomasz R. Sosnowski
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Development of improved analysis of radionuclide images of aerosol deposition
, 2008 Over the last few years, there has been an increase in the clinical methods targeting the human tracheobronchial tree, both for therapeutic and diagnostic purposes.
Montesantos, Spyridon
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In vitro release and in vivo study of quercetin-loaded alginate-kappa carrageenan pulmospheres
Journal of Advanced Pharmaceutical Technology & ResearchSome antituberculosis drugs were reported to have adverse effects. The study investigates the use of quercetin pulmospheres as an alternative to traditional antituberculosis drugs.
Dewi Melani Hariyadi +5 more
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Regional Inhaled Deposited Dose of Urban Aerosols in an Eastern Mediterranean City
Atmosphere, 2019 We calculated the regional deposited dose of inhaled particulate matter based on number/mass concentrations in Amman, Jordan. The dose rate was the highest during exercising but was generally lower for females compared to males.
Tareq Hussein +5 more
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Particle and Fibre Toxicology, 2023 Background Quantifying the dose and distribution of tobacco smoke in the respiratory system is critical for understanding its toxicity, addiction potential, and health impacts.
Kaisen Lin +6 more
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Lung Deposition and Pharmacokinetics of Nebulized Cyclosporine in Lung Transplant Patients [PDF]
Journal of Aerosol Medicine and Pulmonary Drug Delivery, 2014 Inhaled cyclosporine (CsA) is being investigated as a prophylaxis for lung transplant rejection. Lung deposition and systemic exposure of nebulized CsA in lung transplant patients was evaluated as part of the Phase 3 cyclosporine inhalation solution (CIS) trial (CYCLIST).Ten patients received 300 mg of CIS (62.5 mg/mL CsA in propylene glycol) admixed ...
T E, Corcoran +4 more
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