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Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li +7 more
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Solitary nodular pulmonary amyloidosis mimicking primary lung cancer: A case report. [PDF]
Hashimoto R +3 more
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PAH-associated health risk from ultrafine particles: an urban field study. [PDF]
Su WC, Lee J, Afshar M, Zhang K, Han I.
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Intelligence-enabled smart inhalable biomaterials for chronic inflammatory airway diseases: integrating responsive carrier engineering, lung-on-chip validation, and patient-specific pulmonary modeling. [PDF]
Fan Q, Li Z, Sun Y, Liu Y, Chen H.
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Lung deposition from four nebulizers
Respiratory Medicine, 1993The total and regional deposition of aerosol has been compared using four nebulizers; the Pari Boy 37.80, Pari IS-2, RespirGard II and Penta-Sonic. The aerosol was radiolabelled with [99Tcm]DTPA, administered to ten healthy subjects and the distributions monitored by gamma scintigraphy.
J G, Hardy, S P, Newman, M, Knoch
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Deposition of Aerosols in the Lungs: Particle Characteristics
Journal of Aerosol Medicine and Pulmonary Drug Delivery, 2021Of the various particle properties that affect deposition in the respiratory tract, particle diameter and particle density are the most commonly considered, since their effect on deposition is well known and important, as has been discussed earlier in this chapter. However, there are several other particle properties that can affect particle deposition
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The topography of particle deposition in the human lung
Respiration Physiology, 1989The effect of varying particle size on the site of deposition of inhaled particles in the human lung was measured in 11 young healthy male subjects. The simultaneous inhalation of two chemically inert, radiolabelled particles, differing in size but in no other respect, controlled for all other variables including airways geometry, breathing pattern and
P, Pityn +4 more
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Lung aerosol deposition in suckling infants
Archives of Disease in Childhood, 2012Aerosol therapy in infants may be greatly compromised by face mask rejection due to squirming and crying. Lung aerosol deposition in crying infants may thereby be greatly reduced. Since 'suckling' on a pacifier calms infants, they should more readily accept a face mask that incorporates a pacifier.
Israel, Amirav +4 more
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