Results 131 to 140 of about 1,346,074 (337)
Molecular Oncology, EarlyView.Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser +11 more
wiley +1 more source
RELATION OF VITAL CAPACITY OF LUNGS TO CLINICAL CONDITION OF PATIENTS WITH HEART DISEASE [PDF]
, 1917 C. W. MCCLURE
openalex +1 more source
Comparison of the triglyceride lipase of liver, adipose tissue, and postheparin plasma
Journal of Lipid Research, 1972 Heparin-released triglyceride lipase from three sources, adipose tissue, liver, and postheparin plasma, was compared. Heparin-released triglyceride lipase from liver differed in several major respects from that in adipose tissue.
John C. LaRosa +3 more
doaj
Germline variants in CDKN2A wild‐type melanoma prone families
Molecular Oncology, EarlyView.Among melanoma‐prone families, wild‐type for CDKN2A and CDK4, some have pathogenic variants in genes not usually linked to melanoma. Furthermore, rare XP‐related variants and variants in MC1R are enriched in such families. Germline pathogenic variants in CDKN2A are well established as an underlying cause of familial malignant melanoma. While pathogenic
Gjertrud T. Iversen +5 more
wiley +1 more source
A transient inflammatory response contributes to oxaliplatin neurotoxicity in mice
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1985-1998, December 2022., 2022 Abstract Objectives Peripheral neuropathy is a relevant dose‐limiting adverse event that can affect up to 90% of oncologic patients with colorectal cancer receiving oxaliplatin treatment. The severity of neurotoxicity often leads to dose reduction or even premature cessation of chemotherapy.
Aina Calls +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
An Integrated Deep Learning Framework Leveraging NASNet and Vision Transformer with MixProcessing for Accurate and Precise Diagnosis of Lung Diseases [PDF]
arXivThe lungs are the essential organs of respiration, and this system is significant in the carbon dioxide and exchange between oxygen that occurs in human life. However, several lung diseases, which include pneumonia, tuberculosis, COVID-19, and lung cancer, are serious healthiness challenges and demand early and precise diagnostics.
arxiv
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
Hierarchical SegNet with Channel and Context Attention for Accurate Lung Segmentation in Chest X-ray Images [PDF]
arXivLung segmentation in chest X-ray images is a critical task in medical image analysis, enabling accurate diagnosis and treatment of various lung diseases. In this paper, we propose a novel approach for lung segmentation by integrating Hierarchical SegNet with a proposed multi-modal attention mechanism. The channel attention mechanism highlights specific
arxiv