Results 121 to 130 of about 674,704 (375)

Outcomes and Incidence of PF-ILD According to Different Definitions in a Real-World Setting

Frontiers in Pharmacology, 2021
Background: Almost one-third of fibrosing ILD (fILDs) have a clinical disease behavior similar to IPF, demonstrating a progressive phenotype (PF-ILD). However, there are no globally accepted criteria on the definition of a progressive phenotype in non ...
Sebastiano Emanuele Torrisi, Sebastiano Emanuele Torrisi, Nicolas Kahn, Julia Wälscher, Markus Polke, Joyce S. Lee, Philip L. Molyneaux, Philip L. Molyneaux, Francesca Maria Sambataro, Claus Peter Heussel, Carlo Vancheri, Michael Kreuter   +11 more
doaj   +1 more source

Inhibition of RACK1‐Mediated NLRP3 Oligomerization (Active Conformation) Ameliorates Acute Respiratory Distress Syndrome

Advanced Science, EarlyView.
Schematic diagram showing the potential mechanism of bigelovin on the activation of NLRP3 inflammasome Bigelovin may inhibit activated protein C kinase 1 (RACK1) by directly binding with cys168 of RACK1. Bigelovin thus prevents oligomerization of NLRP3 (NLRP3 active conformation) and subsequent assembly of NLRP3 inflammasome, blocking the activation of
Jian Cui, Meng Yang, Chengli Yu, Haidong Zhang, Yuan Gong, Yang Hu, Yue Wang, Qingxin Yuan, An Pan, Jiepin Li, Yaowen Hu, Zecheng Jin, Xuemei Peng, Anyuan Wu, Junwei Wang, Qian Wang, Yinan Zhang, Lihong Hu   +17 more
wiley   +1 more source

Thoracic Manifestations of Connective Tissue Diseases [PDF]

, 2015
Connective tissue diseases (CTDs) comprise several immunologic systemic disorders, each of which associated with a particular set of clinical manifestations and autoimmune profile.
Fernandes, O, Figueiredo, L, Leal, C, Lourenço, J, Lucas, R, Pinheiro, S, Ruano, C   +6 more
core   +1 more source

Semantic Segmentation of Pathological Lung Tissue with Dilated Fully Convolutional Networks [PDF]

, 2018
Early and accurate diagnosis of interstitial lung diseases (ILDs) is crucial for making treatment decisions, but can be challenging even for experienced radiologists. The diagnostic procedure is based on the detection and recognition of the different ILD pathologies in thoracic CT scans, yet their manifestation often appears similar.
arxiv   +1 more source

Multidisciplinary evaluation of interstitial lung diseases: current insights

European Respiratory Review, 2017
Multidisciplinary team (MDT) diagnosis is regarded as the diagnostic reference standard for interstitial lung disease (ILD). Several studies have reported that MDT diagnosis is associated with higher levels of diagnostic confidence and better ...
S. Walsh
semanticscholar   +1 more source

Heavy metal poisoning caused by Chinese folk remedies in psoriasis patients: a retrospective analysis

Scientific Reports
Psoriasis, characterized as a chronic relapsing disease with a protracted course, often drives patients to seek relief through Chinese folk remedies (CFR).
Changjiang Xue, Xuqin Du, Xiaoli Zhu, Na Wu, Qiao Ye   +4 more
doaj   +1 more source

Potential clinical utility of MUC5B und TOLLIP single nucleotide polymorphisms (SNPs) in the management of patients with IPF

Orphanet Journal of Rare Diseases, 2021
Background Genetic variants of TOLLIP and MUC5B, both on chromosome 11, have been reported to be associated with the development and/or prognosis of idiopathic pulmonary fibrosis (IPF).
Francesco Bonella, Ilaria Campo, Michele Zorzetto, Eda Boerner, Shinichiro Ohshimo, Dirk Theegarten, Christian Taube, Ulrich Costabel   +7 more
doaj   +1 more source

PROS1‐MERTK Axis Drives Tumor Microenvironment Crosstalk and Progression in Papillary Thyroid Microcarcinoma

Advanced Science, EarlyView.
Identifying biomarkers associated with PTC, particularly those related to PTMC progression, is crucial for precise risk stratification and treatment planning. This study utilized single‐cell RNA sequencing on 19 surgical tissue specimens, confirmed PROS1/MERTK axis as a critical component of the cellular microenvironment and a key regulatory mechanism ...
Wenqian Zhang, Ye Zhang, Zhu Liu, Zhiyuan Wang, Huaqin Wang, Xiaoyu Ji, Hongyue Su, Fan Yang, Lirong Yan, Ying Xu, Hao Zhang, Wei Sun   +11 more
wiley   +1 more source

Desaturation – distance ratio: a new concept for a functional assessment of interstitial lung diseases [PDF]

, 2010
INTRODUCTION: The functional evaluation has become increasingly important in the understanding and management of patients with interstitial lung diseases.
Baldi, Bruno Guedes, Carvalho, Carlos Roberto Ribeiro, da Rocha, Renata Barbosa, de Melo Kawassaki, Alexandre, Kairalla, Ronaldo Adib, Pimenta, Suzana Pinheiro   +5 more
core   +5 more sources

Isoquercitrin Alleviates Diabetic Nephropathy by Inhibiting STAT3 Phosphorylation and Dimerization

Advanced Science, EarlyView.
This study identified a natural compound, isoquercitrin, which significantly alleviated kidney inflammation and fibrosis by inhibiting STAT3 activity. Isoquercitrin forms a strong, noncovalent bond that directly binds to STAT3. Isoquercitrin binds to the pY+1 pocket of the SH2 domain of STAT3 via hydrogen bonding with Ser668, Gln635, and Gln633 ...
Chen Xuan, Donghui Chen, Shuangna Zhang, Chaofan Li, Qingyun Fang, Dinghua Chen, Jiabao Liu, Xin Jiang, Yingjie Zhang, Wanjun Shen, Guangyan Cai, Xiangmei Chen, Ping Li   +12 more
wiley   +1 more source