Results 91 to 100 of about 801,766 (352)
FEBS Open Bio, EarlyView.Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy +14 more
wiley +1 more source
Deep LF-Net: Semantic Lung Segmentation from Indian Chest Radiographs Including Severely Unhealthy Images [PDF]
arXiv, 2020 A chest radiograph, commonly called chest x-ray (CxR), plays a vital role in the diagnosis of various lung diseases, such as lung cancer, tuberculosis, pneumonia, and many more. Automated segmentation of the lungs is an important step to design a computer-aided diagnostic tool for examination of a CxR.
arxiv
The Intersection of Aging Biology and the Pathobiology of Lung Diseases: A Joint NHLBI/NIA Workshop.
The journals of gerontology. Series A, Biological sciences and medical sciences, 2017 Death from chronic lung disease is increasing and chronic obstructive pulmonary disease has become the third leading cause of death in the United States in the past decade.
G. S. Budinger +27 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik +3 more
wiley +1 more source
Notch signaling in lung diseases: focus on Notch1 and Notch3
Therapeutic Advances in Respiratory Disease, 2016 Notch signaling is an evolutionarily conserved cell–cell communication mechanism that plays a key role in lung homeostasis, injury and repair. The loss of regulation of Notch signaling, especially Notch1 and Notch3, has recently been linked to the ...
Dandan Zong +4 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran +3 more
wiley +1 more source
Extracting Fractional Inspiratory Time from Electrocardiograms [PDF]
arXiv, 2020 Non-invasive at-home monitoring of lung and lung airways health enables the early detection and tracking of respiratory diseases like asthma and chronic obstructive pulmonary disease (COPD). Various proposed approaches estimate the respiratory rate and extract the respiratory waveform from an electrocardiogram (ECG) signal as a way to discreetly ...
arxiv
Blood and sputum biomarkers in COPD and asthma: a review [PDF]
, 2016 Chronic obstructive pulmonary disease (COPD) and asthma are lung inflammatory diseases that represent major public health problems. The primary, and often unique, method to evaluate lung function is spirometry, which reflects disease severity rather than
Conti, V +8 more
core
A poroelastic model coupled to a fluid network with applications in lung modelling [PDF]
arXiv, 2014 Here we develop a lung ventilation model, based a continuum poroelastic representation of lung parenchyma and a 0D airway tree flow model. For the poroelastic approximation we design and implement a lowest order stabilised finite element method. This component is strongly coupled to the 0D airway tree model. The framework is applied to a realistic lung
arxiv
Airway Tree Modeling Using Dual-channel 3D UNet 3+ with Vesselness Prior [PDF]
arXiv, 2022 The lung airway tree modeling is essential to work for the diagnosis of pulmonary diseases, especially for X-Ray computed tomography (CT). The airway tree modeling on CT images can provide the experts with 3-dimension measurements like wall thickness, etc.
arxiv