Results 221 to 230 of about 275,740 (301)

Use of Spirometry for Diagnosis and Management of Chronic Obstructive Pulmonary Disease: An Approach of General Practitioners and Pulmonologists From Karachi, Pakistan. [PDF]

Cureus
Zaina F, Akhtar A, Muqtadir J, Wahab A, Fatima G.   +4 more
europepmc   +1 more source

Procyanidin Capsules Combat ALF by Restoring Mitochondrial Homeostasis and Inhibiting Necroptosis via the PGAM5/DRP1/PINK1 Pathway

Advanced Science, EarlyView.
A biomimetic self‐assembly strategy, Procyanidin Capsules (PC‐Ca), has been developed, which has great stability, bioavailability, and liver‐targeting efficacy and modulates the KEAP1‐NRF2 axis to inhibit ROS formation and necroptosis, regulate mitochondrial homeostasis through the PGAM5/DRP1/PINK1 signaling pathway in thioacetamide (TAA)‐induced ALF ...
Qing Shi, Minmin Wu, Jinwei Zhong, Chao Chen, Zhuang Huang, Jingxuan Peng, Dong Yang, Xingjie Zan, Zhengfei Wang   +8 more
wiley   +1 more source

Variations in multimorbidity measurement in studies evaluating hospitalisation in older adults: a systematic review. [PDF]

BMC Geriatr
Silveira EA, de Oliveira Rezende AT, Rodrigues LP, Nunes BP, Batista SRR, de Oliveira C.   +5 more
europepmc   +1 more source

Gallium‐Doped MXene Nanozymes Protect Liver Through Multi‐Death Pathway Blockade and Hepatocyte Regeneration

Advanced Science, EarlyView.
This study develops gallium‐doped V2C MXene nanozymes (Ga‐V2C) to treat acetaminophen‐induced liver injury through multi‐death pathway blockade and hepatocyte regeneration. Unlike conventional single‐target therapies like N‐acetylcysteine, Ga‐V2C nanozymes enable oxidative stress suppression, apoptosis, and ferroptosis inhibition, and enhanced ...
Xiaopeng Cai, Jingwen Deng, Liqing Wang, Junjie Su, Dongyi Xian, Yilang Yan, Xinyu Yang, Chuanbin Wu, Tingting Peng, Yuan Ding, Guilan Quan, Weilin Wang, Min Zhou, Chao Lu   +13 more
wiley   +1 more source

The role of obesity and Type 2 diabetes in lung health: A systematic review (2024). [PDF]

PLoS One
Lecky R, Grogan S, Shukla P, Atkinson S, McClean PL, Kelly C.   +5 more
europepmc   +1 more source

DEL‐1 is an Endogenous Senolytic Protein that Inhibits Senescence‐Associated Bone Loss

Advanced Science, EarlyView.
Senescent bone marrow stromal cells accumulate in the aging bone microenvironment, promoting bone degeneration. DEL‐1, an endogenous secreted protein, acts as a natural senolytic that selectively eliminates these cells. By engaging a β3 integrin/CD73/adenosine/p38 MAPK/BCL‐2 pathway, DEL‐1 counters aging‐related bone loss, revealing promising ...
Jong‐Hyung Lim, Kridtapat Sirisereephap, Hui Wang, Giulia Trimaglio, Kyoung‐Jin Chung, Jonathan Korostoff, Tetsuhiro Kajikawa, Xiaofei Li, Meircurius D.C. Surboyo, Tomoki Maekawa, Triantafyllos Chavakis, George Hajishengallis   +11 more
wiley   +1 more source

Genome-Wide Cross-Trait Analysis in European Populations Reveals Shared Genetic Architecture of Chronic Obstructive Pulmonary Disease and the Allergy Spectrum.

Int Arch Allergy Immunol
Bu L, Li M.
europepmc   +1 more source

Distinct Morphological Types of Small Airway Obstructions in Smokers with Emphysema and End-Stage Chronic Obstructive Pulmonary Disease. [PDF]

Am J Respir Crit Care Med
Geudens V, De Fays C, Willems L, Vermaut A, Aerts G, Kerckhof P, Kaes J, Hooft C, Jin X, Beeckmans H, Mohamady Y, Aversa L, Goos T, Vermant M, Gyselinck I, Verhaegen J, Van Slambrouck J, Aelbrecht C, Higham A, Coudyzer W, Cortesi EE, Vanstapel A, McDonough JE, Carlon MS, Quarck R, Boone MN, Dupont LJ, Weynand B, Pilette C, Everaerts S, Van Raemdonck DE, Ceulemans LJ, Hogg JC, Hackett TL, Vos R, Wuyts WA, Janssens W, Jacob J, Vanaudenaerde BM, Gayan-Ramirez G.   +39 more
europepmc   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Occupational airborne exposures and asthma mortality - examining asthma as the underlying and contributing cause of death. [PDF]

BMC Pulm Med
Torén K, Murgia N, Åberg M, Andersson M, Järvholm B.   +4 more
europepmc   +1 more source