Results 71 to 80 of about 3,160,530 (245)

Rademikibart for Asthma With Type 2 Biomarkers: Exploratory Subgroup Analyses From a Phase 2b Randomized Clinical Trial

Allergy, EarlyView.
This study reports exploratory and predominantly post hoc subgroup analyses, according to baseline eosinophil count and FeNO levels. In adults with moderate‐to‐severe uncontrolled asthma, rademikibart produced rapid and sustained improvements in lung function and asthma control.
Michael E. Wechsler, Praveen Akuthota, Barry Quart, Raúl Collazo   +3 more
wiley   +1 more source

Domestic Parasitic Infections in Patients with Asthma and Eosinophilia in Germany – Three Cases with Learnings in the Era of Anti- IL5 Treatments

Journal of Asthma and Allergy, 2023
Michaela Barnikel,1,2 Ulrich Grabmaier,3 Pontus Mertsch,1,2 Felix Ceelen,4 Christian Janke,5 Jürgen Behr,1,2 Nikolaus Kneidinger,1,2 Katrin Milger1,2 1Department of Medicine V, LMU University Hospital, Munich, Germany; 2Comprehensive Pneumology Center ...
Barnikel M, Grabmaier U, Mertsch P, Ceelen F, Janke C, Behr J, Kneidinger N, Milger K   +7 more
doaj  

IgE‐Binding Bacterial Components Not Yet Documented in the Allergen Databases and Their Allergenic Mechanisms: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Among bacteria that are associated with the development and/or exacerbation of allergic/atopic diseases, several have been described to produce IgE‐binding components. However, only one bacterial protein, Bac s 1, is currently listed in the official database of the World Health Organization/International Union of Immunological Societies (WHO ...
Uta Jappe, Marua Abu Risha, Ioana Agache, Claus Bachert, Barbara Bröker, Riccardo Castagnoli, Gabriele Gadermaier, Richard E. Goodman, Amir Guemari, Christiane Hilger, Alain Jacquet, Sabine Kespohl, Ludger Klimek, Annette Kuehn, Jonas Lidholm, Vera Mahler, Markus Ollert, Thomas A. Platts‐Mills, Monika Raulf, Peter Schmid‐Grendelmeier, Frieder Schmiedeke, Marianne van Hage, Joana Vitte, Josefina Zakzuk, Anna Pomés   +24 more
wiley   +1 more source

Understanding the Type 2 Immunity: An Evolving View Beyond Allergic Diseases

Allergy, EarlyView.
ABSTRACT Type 2 (T2) immunity is classically associated with defense against helminths and environmental threats, from a physiological perspective, and with allergies and eosinophilic inflammatory diseases, in a pathological sense. However, growing evidence reveals that T2 pathways also support other essential homeostatic functions, including tissue ...
Rodrigo Jiménez‐Saiz, Salvador Iborra, Carlos Blanco, Ruperto González‐Pérez, Emilio Nuñez‐Borque, Can Zeyneloglu, Huseyn Babayev, Ozlem Göksel, Tuncay Göksel, Musa Khaitov, Dmitry Kudlay, Yadong Gao, Mustafa Sevim, Marie‐Charlotte Brüggen, Oral Alpan, Ming Wang, Luo Zhang, María J. Torres, Mohamed Shamji, Mübeccel Akdis, Kari C. Nadeau, Ismail Ogulur, Cezmi A. Akdis   +22 more
wiley   +1 more source

CDC Division of Parasitic Diseases and Malaria strategic priorities 2015\u20132020 [PDF]

Parasitic diseases, which can be transmitted by insect or animal vectors, blood or tissue donation, congenitally, or through contaminated food or water, cause a devastating burden for hundreds of millions of people around the world and in the United ...

core  

Eosinophils in the lung – modulating apoptosis and efferocytosis in airway inflammation

Frontiers in Immunology, 2014
Due to the key role of the lung in efficient transfer of oxygen in exchange for carbon dioxide, a controlled inflammatory response is essential for restoration of tissue homeostasis following airway exposure to bacterial pathogens or environmental toxins.
Jennifer M Felton, Christopher D Lucas, Adriano G Rossi, Ian eDransfield   +3 more
doaj   +1 more source

Diagnostic Delay in Eosinophilic Granulomatosis With Polyangiitis: Clinical Predictors and Implications for Earlier Recognition

Allergy, EarlyView.
This study aimed to assess diagnostic delay among patients with eosinophilic granulomatosis with polyangiitis (EGPA) and identify clinical characteristics associated with delayed recognition. EGPA diagnosis was delayed by nearly five years from symptom onset in this single‐center cohort.
Vani Mulkareddy, Kalena Liu, Shreya Mandloi, Kelsey Limage, Samuel R. Shing, Gurston G. Nyquist, Jessica Most, David Kennedy, Elina Toskala, Damaris Pena‐Evertz   +9 more
wiley   +1 more source

HDAC inhibitors in parasitic diseases

, 2011
Parasitic diseases cause significant global morbidity and mortality, particularly in underdeveloped regions of the world. Malaria alone causes ~800 000 deaths each year, with children and pregnant women being at highest risk. There is no licensed vaccine
Ashraful Haque, Malcolm K Jones, Katherine T Andrews, Haque, Ashraful, Jones, Malcolm K, Andrews, Katherine T., Andrews, Katherine T, Jones, Malcolm K.   +7 more
core   +1 more source

Neglected parasitic infections in the United States [PDF]

Most people think of parasitic diseases occurring in poor and developing countries, something they might pick up on an overseas trip. However, parasitic infections still occur in the United States, and in some cases, affect millions of people. Often they

core   +2 more sources

Mycobacterium tuberculosis peptide-specific T cells in pulmonary granulomas display broad effector functions

iScience
Summary: Mycobacterium tuberculosis (Mtb) peptide-specific T cell responses in granulomas are essential for host protection. Here we profiled macaque and human granuloma Mtb-specific T cells with single cell RNA sequencing after stimulation with peptide ...
Christine E. Nelson, Keith D. Kauffman, Kevin C. Osum, Shunsuke Sakai, Jay Buchanan, Jean M. Chanchu, Melanie Cohen, Julie Laux, Iyadh Dougi, Katherine M. Barrows, Ifeanyichukwu U. Anidi, Cecilia S. Lindestam Arlehamn, Alessandro Sette, April Walker, Amirhossein Shamsaddini, Justin Lack, Joel D. Ernst, Carl G. Feng, Laura E. Via, Kevin P. Fennelly, Shamus R. Carr, Daniel L. Barber   +21 more
doaj   +1 more source