Results 141 to 150 of about 10,890,009 (259)

Oxidative Stress Mechanisms in the Pathogenesis of Environmental Lung Diseases

Oxidative Stress in Lung Diseases, 2019
Globally, respiratory diseases are major cause of disability and mortality, and more alarmingly, it disproportionately affects developing countries, which is largely attributed to poor quality of air. Tobacco smoke and emissions from combustion of fossil
R. Thimmulappa, I. Chattopadhyay, S. Rajasekaran   +2 more
semanticscholar   +1 more source

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

Deep Learning for Lung Disease Classification Using Transfer Learning and a Customized CNN Architecture with Attention [PDF]

arXiv
Many people die from lung-related diseases every year. X-ray is an effective way to test if one is diagnosed with a lung-related disease or not. This study concentrates on categorizing three distinct types of lung X-rays: those depicting healthy lungs, those showing lung opacities, and those indicative of viral pneumonia.
arxiv  

Action of "Tessalon" on the Dyspnoea of Patients with Chronic Lung Disease [PDF]

, 1959
C. S. Darke, Brandy Snowden, D. Vérel, James Daly, W. R. Layland   +4 more
openalex   +1 more source

‘WNT-er is coming’: WNT signalling in chronic lung diseases

Thorax, 2017
Chronic lung diseases represent a major public health problem with only limited therapeutic options. An important unmet need is to identify compounds and drugs that target key molecular pathways involved in the pathogenesis of chronic lung diseases. Over
H. Baarsma, M. Königshoff, M. Königshoff   +2 more
semanticscholar   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

RELATION OF VITAL CAPACITY OF LUNGS TO CLINICAL CONDITION OF PATIENTS WITH HEART DISEASE [PDF]

, 1917
C. W. MCCLURE
openalex   +1 more source

The pathophysiological role of mitochondrial oxidative stress in lung diseases

Journal of Translational Medicine, 2017
Mitochondria are critically involved in reactive oxygen species (ROS)-dependent lung diseases, such as lung fibrosis, asbestos, chronic airway diseases and lung cancer.
Xiaojing Liu, Zhihong Chen
semanticscholar   +1 more source

Peripheral blood leukocyte signatures as biomarkers in relapsed ovarian cancer patients receiving combined anti‐CD73/anti‐PD‐L1 immunotherapy in arm A of the NSGO‐OV‐UMB1/ENGOT‐OV30 trial

Molecular Oncology, EarlyView.
Using mass cytometry, we analyzed serial blood samples from patients with relapsed epithelial ovarian cancer (EOC) treated with oleclumab–durvalumab combination immunotherapy in the NSGO‐OV‐UMB1/ENGOT‐OV30 trial. Our analysis identified potential predictive, monitoring, and response biomarkers detectable through liquid biopsy. These findings facilitate
Luka Tandaric, Annika Auranen, Katrin Kleinmanns, René DePont Christensen, Liv Cecilie Vestrheim Thomsen, Cara Ellen Wogsland, Emmet McCormack, Johanna Mäenpää, Kristine Madsen, Karen Stampe Petersson, Mansoor Raza Mirza, Line Bjørge   +11 more
wiley   +1 more source

Mycobacterium chimaera as An Underestimated Cause of NTM Lung Diseases in Patients Hospitalized in Pulmonary Wards [PDF]

Polish Journal of Microbiology, 2021
ANNA T. ZABOST, MONIKA SZTURMOWICZ, SYLWIA A. BRZEZIŃSKA, MAGDALENA D. KLATT, EWA M. AUGUSTYNOWICZ-KOPEĆ   +4 more
doaj   +1 more source