Results 91 to 100 of about 1,914,004 (302)

Genetic variants affecting cross-sectional lung function in adults show little or no effect on longitudinal lung function decline [PDF]

, 2017
Background: Genome-wide association studies have identified numerous genetic regions that influence cross-sectional lung function. Longitudinal decline in lung function also includes a heritable component but the genetic determinants have yet to be ...
Abecasis, Afzal, Alan James, American Thoracic Society, American Thoracic Society, Anders Malarstig, Arthur W Musk, Børge G Nordestgaard, Castaldi, Catherine John, Cho, Collins, Curjuric, DeMeo, Devlin, Fletcher, Gottlieb, Hancock, Hansel, Hole, Howie, Iain Kilty, Ian P Hall, Imboden, James, James, James, Jennie Hui, John Beilby, Kathleen Barnes, Lange, Li, Liao, Loth, Louise V Wain, Martin D Tobin, María Soler Artigas, Nadia N Hansel, Nicholas Rafaels, Nick Shrine, Patterson, Peter D Paré, Pillai, Price, Purcell, Repapi, Ryan, Schnohr, Schunemann, Scott A Jelinsky, Signe Vedel-Krogh, Soler Artigas, Soler Artigas, Sune Fallgaard Nielsen, Tang, Thun, Wilk, Wilk   +57 more
core   +2 more sources

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Implementing nitrogen multiple breath washout as a clinical tool – A feasibility study

Pulmonology, 2021
Carolina Constant, Andreia Descalço, Ana Margarida Silva, Luísa Pereira, Celeste Barreto, Teresa Bandeira   +5 more
doaj   +3 more sources

STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death [PDF]

, 2019
STING gain-of-function mutations cause lung disease and T cell cytopenia through unknown mechanisms. Here, we found that these mutants induce chronic activation of ER stress and unfolded protein response (UPR), leading to T cell death by apoptosis in ...
Chen, Yu-Ju, Dobbs, Nicole, Liou, Jen, Miner, Jonathan J, Sakai, Tomomi, Wu, Jianjun, Yan, Nan   +6 more
core   +1 more source

Lymphatic function is required prenatally for lung inflation at birth [PDF]

, 2014
Mammals must inflate their lungs and breathe within minutes of birth to survive. A key regulator of neonatal lung inflation is pulmonary surfactant, a lipoprotein complex which increases lung compliance by reducing alveolar surface tension (Morgan, 1971)
Adams, Alders, Aslihan Sen, Atochina-Vasserman, Avery, Bellini, Bland, Bourbon, Celeste M. Nelson, Clark, Compernolle, Couser, David R. Enis, David R. Rawnsley, Guyton, Haddy, Hintz, Hummler, Janér, Jason P. Gleghorn, Jisheng Yang, Kaipainen, Karkkainen, Karkkainen, Kobayashi, Kulkarni, Laurence, Lee, Mark L. Kahn, Martel, Milner, Moessinger, Morgan, Morikawa, Mäkinen, Nogee, Noonan, Patrick, Paul R. Hess, Schnitzer, Sharp, Stephanie Chia, Suresh, Susan H. Guttentag, Tammela, Wang, Wigle, Xi Liu, Yiqing Yang, Zhang, Zhiying Zou, Zoltán Jakus, Zou   +52 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Drug-based mobilisation of mesenchymal stem/stromal cells improves cardiac function post myocardial infarction

Disease Models & Mechanisms, 2023
Veneta B. Todorova, Nicoleta Baxan, Matthew Delahaye, Sian E. Harding, Sara M. Rankin   +4 more
doaj   +1 more source

Management of severe acute exacerbations of COPD: an updated narrative review

Multidisciplinary Respiratory Medicine, 2018
Background Patients with chronic obstructive pulmonary disease (COPD) may experience an acute worsening of respiratory symptoms that results in additional therapy; this event is defined as a COPD exacerbation (AECOPD).
Ernesto Crisafulli, Enric Barbeta, Antonella Ielpo, Antoni Torres   +3 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Apical surface supracellular mechanical properties in polarized epithelium using noninvasive acoustic force spectroscopy

Nature Communications, 2017
Determination of apical tension, fluidity, and intercellular adhesive forces in an epithelial monolayer are currently disruptive. Here the authors present a method using acoustic force microscopy to measure changes in these parameters upon tight junction
Alexander X. Cartagena-Rivera, Christina M. Van Itallie, James M. Anderson, Richard S. Chadwick   +3 more
doaj   +1 more source