Results 91 to 100 of about 1,239,389 (314)

Management of severe acute exacerbations of COPD: an updated narrative review

Multidisciplinary Respiratory Medicine, 2018
Background Patients with chronic obstructive pulmonary disease (COPD) may experience an acute worsening of respiratory symptoms that results in additional therapy; this event is defined as a COPD exacerbation (AECOPD).
Ernesto Crisafulli, Enric Barbeta, Antonella Ielpo, Antoni Torres   +3 more
doaj   +1 more source

Race, ethnicity and lung function: A brief history [PDF]

, 2015
Spirometry is the most common lung function test and represents the cornerstone diagnostic and management tool for individuals with chronic respiratory diseases.
Lundy Braun
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Apical surface supracellular mechanical properties in polarized epithelium using noninvasive acoustic force spectroscopy

Nature Communications, 2017
Determination of apical tension, fluidity, and intercellular adhesive forces in an epithelial monolayer are currently disruptive. Here the authors present a method using acoustic force microscopy to measure changes in these parameters upon tight junction
Alexander X. Cartagena-Rivera, Christina M. Van Itallie, James M. Anderson, Richard S. Chadwick   +3 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Mechanisms of Lung Injury in a Mouse Model of Bronchopulmonary Dysplasia

, 2009
Bronchopulmonary dysplasia (BPD) is a chronic lung disease that affects preterm infants. Increased levels of inflammatory mediators in the amniotic fluid and in the lungs of preterm infants are associated with the development of BPD.
Hogmalm, Anna
core  

Influence of lung function on course of disease and response to antibiotic therapy in adult primary care patients with acute cough: a post hoc analysis of patients enrolled in a prospective multicentre study

, 2014
BACKGROUND: In acute cough patients, impaired lung function as present in chronic lung conditions like asthma and chronic obstructive pulmonary disease (COPD) are often thought to negatively influence course of disease, but clear evidence is lacking.AIMS:
Verheij, Theo J M, Leven, Margareta, Moore, Michael, Verheij, TJ, Thomas, Mike, Verheij, Theo J.M., Stuart, B, Hood, K, Coenen, Samuel, Stuart, Beth, Goossens, Herman, Goossens, H, Little, Paul, Moore, M, Coenen, S, Little, P, van Erp, Nicole, Thomas, M, Hood, Kerenza, van Erp, N, Butler, Chris C., Butler, CC, Leven, M   +22 more
core   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation [PDF]

, 2015
Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC ...
Shrine, Nick, Caroline Hayward (149856), Ingelsson, E., Stubbe, B., Sayers, Ian, Surakka, I., Igor Rudan (150101), Stubbe, B, Kemp, John P, Miller, Suzanne, Sandosh Padmanabhan (238533), Joachim Heinrich (60421), Pavord, I, González, Juan R., Huffman, JE, Sin, Don D., Trochet, Holly, Huffman, Jennifer E., Janina S. Ried (7693763), Lehtimäki, T., Navarro, Pau, Harris, Sarah E, Hysi, Pirro G., Lyytikäinen, Leo Pekka, Glaeser, S, Heinrich, Joachim, Lind, Lars, Jennifer E. Huffman (7665404), Hammond, Chris J, Probst-Hensch, Nicole M, Navarro, P, Deary, Ian J, Enroth, S., Evans, DM, Wild, SH, Louise V. Wain (7588511), Gieger, C, Imboden, M., Hysi, PG, Hartikainen, Anna-Liisa, Holger Schulz (13022), Jarvelin, Marjo-Riitta, Surakka, Ida, Wright, Alan F, Lopez, Lorna M., James, A.L., Starr, John M., Tim D. Spector (7588592), Gyllensten, Ulf,, Campbell, Harry; id_orcid, Granell, Raquel, Christian Gieger (87555), Strachan, David P., Jarvelin, M.R., Henry Völzke (64286), Momoko Horikoshi (426678), Melén, E., Kolcic, I., Obeidat, Ma�en, Pavord, Ian, Ingelsson, Erik, Musk, Arthur W., Jackson, VE, ?, ?, Robert A. Scott (160581), Zhao, Jing Hua, Ntalla, I., Lehtimäki, Terho, Gl�ser, Sven, Hansell, AL, Bossé, Y., Ida Surakka (120325), Lopez, L.M., Viñuela, Ana, Imboden, Medea, Ried, Janina S, Gyllensten, U., Obeidat, Ma’en, Nick Shrine (220391), Marchini, J, Ried, J.S., Raitakari, Olli T., Vitart, Veronique, Horikoshi, M, Johansson, Åsa,, Samuli Ripatti (144251), Huffman, Jennifer E, Musk, AW, Miller, S., Kähönen, M., Probst-Hensch, NM, Morris, AP, Mel�n, Erik, Wright, A.F., Marchini, Jonathan, Tobin, M.D., Nicole M. Probst-Hensch (7634162), Eva Albrecht (174584), Pau Navarro (160568), Erik Melén (276082), Deborah L. Jarvis (7693766), Wareham, N.J., Morris, Andrew P, Scott, Robert A., Ian P. Hall (7377620), Probst-Hensch, Nicole M., Brandsma, C.A., Jarvis, Deborah L., González, Juan R, Hall, I.P., Artigas, M.S., Wain, Louise V., Raquel Granell (123318), Henderson, John, Marten, J., Joshi, PK, David C. Nickle (7693760), McArdle, Wendy L., Wilson, James F, Holly Trochet (2168617), Artigas, Mar�a Soler, Ntalla, I, Kähönen, Mika, Beilby, J, Melen, E, Gyllensten, Ulf, Tobin, Martin D, Kemp, J.P., Bosse, Y, Nina Hutri-Kähönen (186365), Generation Scotland (3497906), Viñuela, A., BiLeve, U. K., Probst-Hensch, N.M., Ripatti, S., Kumar, Ashish, Joshi, Peter K, Nickle, D.C., Henderson, J, Wright, AF, Teumer, A., Vi�uela, Ana, Terho Lehtimäki (49739), Marjo-Riitta Jarvelin (110290), Wareham, NJ, Ioanna Ntalla (174685), Wright, Alan F., Beilby, John, Rawal, Rajesh, Teumer, A, John P. Kemp (7693754), Polasek, Ozren, Morris, Andrew P., Polasek, O., Rajesh Rawal (528458), Ried, JS, Scott, R.A., Wild, Sarah H; id_orcid, Hall, IP, Marten, Jonathan, Alves, A.C., Wild, Sarah H, Deloukas, Panos, Harry Campbell (30339), Lind, L, Wareham, Nicholas J., Obeidat, M, Rudan, I., Don D. Sin (7657253), Musk, A.W., Starr, JM, Boss�, Yohan, Harris, SE, Lopez, Lorna M, Alan L. James (7675358), Kheirallah, AK, Hutri-Kähönen, Nina, Evans, David M, Alves, Alexessander Couto, Wilson, James F., Artigas, María Soler, Lars Lind (88400), Bossé, Yohan, Kemp, John P., Ulf Gyllensten (13773), Zhao, J.H., Brandsma, Corry Anke, Thomson, Neil C., Zhao, JH, Lehtimaki, T, Raitakari, O.T., Deary, Ian J., Ozren Polasek (3965693), Kumar, A., Shrine, N, Vitart, V, Evans, David M., Voelzke, Henry, Hayward, C, Yohan Bossé (69571), Ingelsson, E, Kemp, JP, Ntalla, Ioanna, Suzanne Miller (460145), Sarah E. Harris (7693751), Jarvis, Deborah L, Strachan, DP, Lorna M. Lopez (7693742), Tatijana Zemunik (150001), Sin, D.D., Spector, TD, Lynne Hocking (3819640), Miller, S, Marten, J, Vinuela, A, Heliovaara, M, Hutri-Kahonen, N, Lind, Lars,, Evans, D.M., Corry-Anke Brandsma (41865), Stubbe, Beate, Ma'en Obeidat (110232), Hartikainen, A.L., Andrew P. Morris (6733298), Gyllensten, U, Tobin, MD, Wain, LV, Karrasch, S., Deloukas, P, Alexander Teumer (112757), Obeidat, Ma'en, Hysi, P.G., Horikoshi, M., Strachan, David P, Schulz, H, Hui, J., Raitakari, Olli T, Hayward, C., Harald Grallert (72666), Karrasch, S, Campbell, Harry, Campbell, H, Heli�vaara, Markku, Gonzalez, J.R., Kolcic, I, Lyytikäinen, L.-P., Joshi, Peter K., Sin, DD, Gläser, S., V�lzke, Henry, Heinrich, J., Markku Heliövaara (81299), Lyytikainen, L-P, Sven Gläser (110276), Nicholas J. Wareham (7584569), Trochet, H., Grallert, H., Abdul Kader Kheirallah (7643393), Spector, Tim D., Zeggini, E, Stefan Karrasch (412837), Ashish Kumar (152984), Mika Kähönen (131499), Beate Koch (110151), Starr, J.M., Jarvelin, Marjo Riitta, Arthur W. Musk (7693757), Leo-Pekka Lyytikäinen (144253), Gonzalez, JR, Ripatti, S, Kumar, A, Wareham, Nicholas J, Enroth, Stefan,, Gieger, C., Hutri-Kähönen, N., Kheirallah, Abdul Kader, Zeggini, Eleftheria, Musk, Arthur W, Joshi, P.K., Artigas, MS, Hocking, L.J., UK BiLEVE, Johansson, A, Alan F. Wright (7665419), Enroth, Stefan, John Henderson (123324), Grallert, Harald, John Beilby (405654), Lyytikäinen, Leo-Pekka, Hammond, Chris J., Hubbard, R, Jarvelin, M-R, Wilson, J.F., Harris, S.E., Lehtim�ki, Terho, Obeidat, M., James, Alan L, Jing Hua Zhao (7634084), Stefan Enroth (189126), Hartikainen, Anna Liisa, Deary, IJ, Karrasch, Stefan, Padmanabhan, Sandosh, Völzke, Henry, Raitakari, OT, Olli T. Raitakari (7588757), Granell, R., Melén, Erik, Brandsma, C-A, Hocking, L, Campbell, H., Schulz, Holger, Harris, Sarah E., Heinrich, J, Wild, S.H., Alves, AC, Martin D. Tobin (7581161), Enroth, S, UK BiLEVE (7675361), Beilby, J., Wilson, James F; id_orcid, Johansson, �sa, Gläser, Sven, Mahajan, A, Heliövaara, Markku, Flexeder, Claudia, Medea Imboden (110145), Teumer, Alexander, Hysi, Pirro G, Anubha Mahajan (206768), Albrecht, E., Navarro, Pau; id_orcid, Lind, L., Deary, I.J., Ian J. Deary (6650307), Ivana Kolcic (3212697), Chris J. Hammond (7693748), Jonathan Marten (3819643), Sin, Don D, Hall, Ian P, Surakka, I, Wain, L.V., Zemunik, Tatijana, Navarro, P., Shrine, N., James, AL, Juan R. González (7693745), Sarah H. Wild (7512197), Rudan, Igor, Huffman, J.E., Åsa Johansson (84687), Hubbard, Richard, Kheirallah, A.K., Veronique Vitart (149854), David P. Strachan (7634177), McArdle, W.L., James F. Wilson (7638917), Soler Artigas, María, Zemunik, T., Trochet, H, Pirro G. Hysi (7634090), Hayward, Caroline, Völzke, H., Lopez, LM, Flexeder, C, Jarvis, D.L., Sayers, I., Wendy L. McArdle (7634075), Hansell, Anna L., Hammond, C.J., Scott, Robert A, Voelzke, H, Claudia Flexeder (412834), Alexessander Couto Alves (131470), Jennie Hui (220409), María Soler Artigas (110124), Gieger, Christian, Hammond, CJ, Scott, RA, Thomson, Neil, Thomson, NC, McArdle, Wendy L, Mahajan, A., Glaeser, Sven, Spector, Tim D, Jackson, Victoria E., Padmanabhan, S, Imboden, M, Hui, Jennie, Hui, J, Granell, R, Gonz�lez, Juan R., Henderson, J., McArdle, WL, Rawal, R., Ried, Janina S., Starr, John M, Sayers, I, Albrecht, E, Hartikainen, A-L, K�h�nen, Mika, Brandsma, Corry-Anke, Nickle, DC, Hutri-K�h�nen, Nina, Kolcic, Ivana, Kahonen, M, Padmanabhan, S., Spector, T.D., Heliövaara, M., Schulz, H., Wilson, JF, Peter K. Joshi (7693739), Brandsma, Corry-Anke; id_orcid, Rawal, R, Nickle, David C, Rudan, I, Wild, Sarah H., Grallert, H, Johansson, Åsa, David M. Evans (7190417), Morris, A.P., Ian Sayers (37266), John M. Starr (7041266), Ana Viñuela (207015), Ingelsson, Erik,, Albrecht, Eva, Hall, Ian P., Zemunik, T, Lyytik�inen, Leo-Pekka, Tobin, Martin D., James, Alan L., Jarvis, DL, Hayward, Caroline; id_orcid, Wain, Louise V, Ripatti, Samuli, Polasek, O, Erik Ingelsson (232651), Flexeder, C., Anna-Liisa Hartikainen (110272), Nickle, David C., Mahajan, Anubha, Hocking, Lynne, Horikoshi, Momoko   +442 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source