Results 61 to 70 of about 1,239,389 (314)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

A Novel Curcumin-Based Drug Powder Inhalation Medicine for Chronic Obstructive Pulmonary Disease

Bioinorganic Chemistry and Applications, 2021
The dry powder inhaler is a new form of drug delivery that is widely used as an alternative to traditional drug delivery methods, addressing the shortcomings of traditional drug delivery methods and obtaining better therapeutic results.
Qin Shen, Yongjie Jiang, Jing Chen, Xueling Wang, Jiao Zheng   +4 more
doaj   +1 more source

Childhood IQ and social factors on smoking behaviour, lung function and smoking-related outcomes in adulthood: linking the Scottish Mental Survey 1932 and the Midspan studies [PDF]

, 2005
OBJECTIVE: To investigate the associations of childhood IQ and adult social factors, and smoking behaviour, lung function (forced expiratory volume in one second; FEV(1)), and smoking-related outcomes in adulthood.
Wilson, V, Whalley, LJ, Whalley, L.J., Hart, CL, Hole, D., Hole, DJ, Taylor, M.D., Smith, G.D., Starr, JM, Taylor, MD, Hart, C.L., Deary, IJ, Starr, J.M., Wilson, V., Davey Smith, G, Deary, I.J.   +15 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The avian lung-associated immune system [PDF]

, 2006
The lung is a major target organ for numerous viral and bacterial diseases of poultry. To control this constant threat birds have developed a highly organized lung-associated immune system.
Reese, Sven, Dalamani, Grammatia, Kaspers, Bernd, Sven Reese, Grammatia Dalamani, Bernd Kaspers   +5 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Cardiomyocyte Membrane Structure and cAMP Compartmentation Produce Anatomical Variation in β2AR-cAMP Responsiveness in Murine Hearts

Cell Reports, 2018
Summary: Cardiomyocytes from the apex but not the base of the heart increase their contractility in response to β2-adrenoceptor (β2AR) stimulation, which may underlie the development of Takotsubo cardiomyopathy.
Peter T. Wright, Navneet K. Bhogal, Ivan Diakonov, Laura M.K. Pannell, Ruwan K. Perera, Nadja I. Bork, Sophie Schobesberger, Carla Lucarelli, Giuseppe Faggian, Anita Alvarez-Laviada, Manuela Zaccolo, Timothy J. Kamp, Ravi C. Balijepalli, Alexander R. Lyon, Sian E. Harding, Viacheslav O. Nikolaev, Julia Gorelik   +16 more
doaj   +1 more source

The Beta Agonist Lung Injury TrIal (BALTI) : prevention trial protocol [PDF]

, 2011
Background: Acute lung injury complicates approximately 25-30% of subjects undergoing oesophagectomy. Experimental studies suggest that treatment with beta agonists may prevent the development of acute lung injury by decreasing inflammatory cell ...
Matthew W Cooke, Thickett, David R, Cooke, MW, Lamb, S. E. (Sallie E.), Thickett David R, David R Thickett, Cooke, Matthew (Professor of clinical systems design), Lamb, Sarah E, Gao, F, Perkins, Gavin D., Gates, S, Daniel Park, Mistry Dipesh, Alderson, D, Fang Gao, Gao, Fang; id_orcid, Alderson, Derek, Cooke Matthew W, Gao Fang, Mistry, D, Dipesh Mistry, Alderson Derek, Perkins, GD, Gao, Fang, Mistry, Dipesh, Park, Daniel P., Park Daniel, Cooke, Matthew W, Thickett, David R; id_orcid, Thickett, DR, Gates, Simon, Lamb, Sarah, Sarah E Lamb, Park, Daniel, Gavin D Perkins, Park, D, Perkins, Gavin D, Simon Gates, Thickett, David R., Smith, F. Gao (Fang Gao), Gates Simon, Lamb Sarah E, Derek Alderson, Perkins Gavin D, Lamb, SE   +44 more
core   +1 more source