Results 111 to 120 of about 4,146,103 (355)

In vivo Detection of Hyperoxia-induced Pulmonary Endothelial Cell Death Using \u3csup\u3e99m\u3c/sup\u3eTc-Duramycin [PDF]

, 2015
Introduction 99mTc-duramycin, DU, is a SPECT biomarker of tissue injury identifying cell death. The objective of this study is to investigate the potential of DU imaging to quantify capillary endothelial cell death in rat lung injury resulting from ...
Audi, Said H., Clough, Anne V., Haworth, Steven T., Jacobs, Elizabeth R., Roerig, David L., Zhao, Ming   +5 more
core   +1 more source

Adipose-derived stem cells weigh in as novel therapeutics for acute lung injury [PDF]

, 2014
Acute lung injury is characterized by intense neutrophilic lung inflammation and increased alveolar-capillary barrier permeability leading to severe hypoxemia, and is associated with high mortality despite improvements in supportive care.
Gupta, Kushagra, Hergrueter, Anja, Owen, Caroline A   +2 more
core   +1 more source

Exosomes from endothelial progenitor cells improve outcomes of the lipopolysaccharide-induced acute lung injury

Critical Care, 2019
BackgroundThe acute respiratory distress syndrome (ARDS) is characterized by disruption of the alveolar-capillary barrier resulting in accumulation of proteinaceous edema and increased inflammatory cells in the alveolar space.
Yue Zhou, Pengfei Li, A. Goodwin, J. Cook, P. Halushka, E. Chang, B. Zingarelli, Hongkuan Fan   +7 more
semanticscholar   +1 more source

Vaping-Induced Lung Injury.

New England Journal of Medicine, 2020
A number of environmental agents are known to cause acute or subacute inhalation injury to the lung parenchyma.
D. Christiani
semanticscholar   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Monitoring of lung edema by microwave reflectometry during lung ischemia-reperfusion injury in vivo [PDF]

, 2006
It is still unclear whether lung edema can be monitored by microwave reflectometry and whether the measured changes in lung dry matter content (DMC) are accompanied by changes in PaO(2) and in pro-to anti-inflammatory cytokine expression (IFN-gamma and ...
Blades B, Bland JM, D'Armini AM, Date H, DeMeo DL, Eppinger M, Eppinger MJ, Fein A, Fonkalsrud EW, Kaatze U, Kai Nowak, Kondo Y, Martha Maria Gebhard, Matsuda S, Michael Schaefer, Miura N, Nierman DM, Palazzo R, Peter Hohenberger, Rigaud B, Roman Patrick Metzger, Schaefer M, Schaefer M, Schaefer M, Stefan Post, Trulock EP, Van Raemdonck DE, West JB, Wichert PV, Wolfgang Gross, Yamazaki F   +30 more
core   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Protection by 20-5,14-HEDGE Against Surgically-Induced Ischemia Reperfusion Lung Injury in Rats [PDF]

, 2012
Background We previously reported that the cytochrome P450 product 20-hydroxyeicosatetraenoic acid has prosurvival effects in pulmonary artery endothelial cells and ex vivo pulmonary arteries.
Ali, Irshad, Clough, Anne V., Falck, John R., Gao, Ying, Gruenloh, Stephanie, Jacobs, Elizabeth R., Medhora, Meetha   +6 more
core   +2 more sources

Differential effects of extracellular vesicles from aging and young mesenchymal stem cells in acute lung injury

Aging, 2019
Old age is a known risk factor for mortality in acute respiratory distress syndrome (ARDS)/acute lung injury. Mesenchymal stem cells (MSCs) possess potent immunomodulatory properties, while aging MSCs have reduced capacity.
Ruoqiong Huang, Chaojin Qin, Jiangmei Wang, Yaoqin Hu, G. Zheng, Guanguan Qiu, Menghua Ge, Huikang Tao, Q. Shu, Jianguo Xu   +9 more
semanticscholar   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source