Results 91 to 100 of about 494,720 (246)

Single-cell multiomics analysis reveals CTCF as a key regulator of lung morphogenesis and progenitor maintenance

Nature Communications
Lung development generates a complex tree-like architecture through proximal-distal patterning and branching morphogenesis. However, the gene regulatory programs governing embryonic lung development remain poorly understood.
Shenfei Sun, Yamei Jiang, Fujing Huang, Wei Wei, Mathias Hochgerner, Tianmin Xu, Xiaoting Wang, Kaijun Lin, Xinna Zhang, Yanli Wang, Hua He, Miao Yu, Xiaofang Tang, Xinhua Lin   +13 more
doaj   +1 more source

Use of pressure muscle index to predict the contribution of patient’s inspiratory effort during pressure support ventilation: a prospective physiological study

Frontiers in Medicine
BackgroundThe successful implementation of assisted ventilation depends on matching the patient’s effort with the ventilator support. Pressure muscle index (PMI), an airway pressure based measurement, has been used as noninvasive monitoring to assess the
Ran Gao, Ran Gao, Jian-Xin Zhou, Yan-Lin Yang, Shan-Shan Xu, Yi-Min Zhou, Linlin Zhang, Ming-Yue Miao   +7 more
doaj   +1 more source

Hybrid Continuum Robot Designs and Architectures for Healthcare Applications

Advanced Robotics Research, EarlyView.
Hybrid continuum robots represent an emerging class of flexible manipulators that blend materials, structures, and actuation concepts from the established fields of soft and continuum robotics. This review introduces an accessible framework to distinguish key hybridization approaches, surveys current designs aimed at complex clinical applications, and ...
Burak Ozdemir, Muhammad A. Khalid, Manish Chauhan, Pietro Valdastri, James H. Chandler   +4 more
wiley   +1 more source

The role of biofilm formation by Pseudomonas aeruginosa in respiratory tract infections and its impact on patient prognosis

European Journal of Medical Research
Background Pseudomonas aeruginosa is a prevalent nosocomial pathogen causing respiratory tract infections, and its biofilm formation poses challenges to treatment and influences prognosis.
Xiaohuan Wang, Kaijing Gao, Shuo Yang, Tongtong Tian, Beili Wang, Yuanlin Song, Wei Guo   +6 more
doaj   +1 more source

Miniaturized Magnetic Tip Design for Endoluminal Vine Robot Navigation

Advanced Robotics Research, EarlyView.
A magnetic tip mount is designed for a miniaturized 7 mm soft‐growing vine robot to enable wireless magnetic steering and onboard imaging, while preserving a 3 mm working channel. The internal–external ring magnets design balances magnetic attachment with low eversion pressure. Experiments demonstrate ±90° steering, 34 mm bending radius, and successful
Andrea Yanez Trujillo, Joshua Davy, James H. Chandler, James Avery, Pietro Valdastri   +4 more
wiley   +1 more source

Assessing agreement among non-invasive indicators for inspiratory effort during pressure support ventilation

Frontiers in Medicine
BackgroundDuring pressure support ventilation (PSV), the accuracy of non-invasive indicators in diagnosing high or low inspiratory effort has been validated. However, the correlation and agreement of these indicators remain unclear.
Wen-Yi Lv, Wen-Yi Lv, Shuai Liu, Linlin Zhang, Jian-Xin Zhou   +4 more
doaj   +1 more source

Real‐Time Holographic Feedback via Mixed Reality Sensorized Laryngoscope Training System Enhances Pediatric Intubation Training

Advanced Robotics Research, EarlyView.
We proposed a Mixed Reality Sensorized Laryngoscope Training System to provide real‐time holographic torque feedback during pediatric endotracheal intubation simulation. Visualization formats are evaluated to reduce tracking error and visual demand.
Jiaqi Li, Ryman Hashem, Ningzhe Hou, Perla Maiolino, Louis Halamek, Liang He   +5 more
wiley   +1 more source

Plasma microbial cell-free DNA load is associated with mortality in patients with COVID-19

Respiratory Research, 2021
Georgios D. Kitsios, William Bain, Nameer Al-Yousif, Radha Duttagupta, Asim A. Ahmed, Bryan J. McVerry, Alison Morris   +6 more
doaj   +1 more source

Stromal‐Derived IL‐8 Promotes M2 Macrophage Polarization via the RhoA/MRTF‐A/SRF Transcriptional Axis to Impair CD8+ T Cell Cytotoxicity in Lung Cancer

Advanced Science, EarlyView.
In the recondite pulmonary neoplastic milieu, DESMIN+ cancer‐associated fibroblasts function as the paramount stromal source of IL‐8, precipitating a deleterious immunological metamorphosis by engaging CXCR2 receptors on the myeloid lineage. This paracrine stimulus triggers a mechanotransduction cascade characterized by RhoA‐dependent actin ...
Xuyu Gu, Qiyu Fang, Jia Yu, Ting Yu, Huashan Shi, Kaiqi Jin, Lei Jiang, Wentian Zhang   +7 more
wiley   +1 more source

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro‐Inflammatory Endothelial Cells

Advanced Science, EarlyView.
Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia, William Y. Wang, Kyle A. Jacobs, Kairav Maniar, Daphne Lin, Evan H. Jarman, Daniel L. Matera, Kristen Loesel, Christopher D. Davidson, Harrison L. Hiraki, Xiaotian Tan, Eve H. Shikanov, Robert N. Kent, Carole Parent, Xudong Fan, Ariella Shikanov, Matthew L. Kutys, Brendon M. Baker   +17 more
wiley   +1 more source