Results 111 to 120 of about 900,764 (306)

Lung nodule classification utilizing support vector machines [PDF]

, 2002
Lung cancer is one of the deadly and most common diseases in the world. Radiologists fail to diagnose small pulmonary nodules in as many as 30% of positive cases.
Khan, M.A.U., Mousa, W.A.H.
core  

AARS1‐Mediated RUNX3 K193 Lactylation Enhances the Activation and Cytotoxicity of CD8+T Cells in Smoking‐Related Emphysema

Advanced Science, EarlyView.
Exposure to CS causes an elevation of AARS1 levels, which increases the levels of RUNX3 lactylation at the K193 site and increases protein levels of RUNX3 through inhibition of autolysosomal degradation. Elevated RUNX3 levels promote CD8+T cell activation and augment their cytotoxicity, which induces alveolar epithelial cell death and facilitates the ...
Ying Zhu, Jiaheng Lin, Yifan Li, Qiaoqiao Zhou, Min Yu, Cheng Cheng, Kang Chang, Dang Lin, Tao Bian, Yan Wu, Lu Lu, Haibo Xia, Qizhan Liu   +12 more
wiley   +1 more source

Lanthanum Carbonate Nanosheets Based Colloidal Hydrogel for Modulating Innate & Adaptive Tumor Immunotherapy by Augmented Cellular Pyroptosis

Advanced Science, EarlyView.
The Gela/decitabine/La2(CO3)3 colloidal (GDLC) hydrogel developed here could reverse the epigenetic silencing of the GSDME gene by the synergistic interaction between DAC and La3+, while concurrently activating caspase‐3, thus facilitating pyroptosis induction under the tumor microenvironment.
Yang Hong, Haitao Wu, Weitao Wang, Xuan Zhang, Qian Chen, Yaoyu Hu, Zhengbao Zha   +6 more
wiley   +1 more source

Performance evaluation results of lung nodule classification.

Performance evaluation results of lung nodule classification.
Akimichi Ichinose (3511655), Shingo Iwano (3663433), Shinji Naganawa (534021), Yohei Momoki (18196229), Keiichiro Yamada (18196235), Shinichiro Kamiya (18196232), Keigo Nakamura (3162762)   +6 more
core   +1 more source

Transcription Factor HOXC11 Drives Colorectal Cancer Progression and Metastasis via CAMK2A‐Dependent CXCL5 Upregulation

Advanced Science, EarlyView.
HOXC11 drives colorectal cancer progression by transcriptionally activating CAMK2A, which triggers NF‐κB–dependent CXCL5 upregulation. CXCL5–CXCR2 signaling further reinforces HOXC11 expression through the ERK1/2–SP1 axis, forming a prometastatic positive feedback loop that is effectively disrupted by combined CAMK2A and CXCR2 inhibition.
Qingyang Sun, Hengjie Xu, Sheng Yang, Jiahui Zhou, Chuanxin Tian, Hongxu Nie, Chi Jin, Tuo Wang, Zhihao Chen, Junwei Tang, Yifei Feng, Xiaowei Wang, Yueming Sun   +12 more
wiley   +1 more source

Lung Nodule Management in Low-Dose CT Screening for Lung Cancer:Lessons from the NELSON Trial [PDF]

Screening with low-dose CT (LDCT) in a high-risk population, as defined by age and smoking behavior, reduces lung cancer-related mortality. However, LDCT screening presents a major challenge.
Aerts, Joachim G, Groen, Harry J.M., Gietema, H.A., Heuvelmans, M.A., de Bock, Geertruida H., Gietema, Hester A, Stadhouders, R., de Bock, Geertruida H, Aerts, Joachim G., Jong, Pa. de, Groen, H.J.M., Bock, G.H. de, Vliegenthart, R., Heuvelmans, Marjolein A., Sidorenkov, Grigory, de Bock, Geertruida H; id_orcid, Jacobs, Colin, Nackaerts, Kristiaan, de Jong, Pim A., Groen, Harry J M, Prokop, M., de Jong, Pim A, Jacobs, C., Prokop, Mathias; id_orcid, Zhong, D., Nackaerts, K., Sidorenkov, Grigory; id_orcid, Gietema, Hester A., Vliegenthart, Rozemarijn, Prokop, Mathias, Sidorenkov, G., Heuvelmans, Marjolein A, Zhong, Danrong, Stadhouders, Ralph, Groen, Harry J M; id_orcid, Aerts, J.G.   +35 more
core   +2 more sources

Lung nodule malignancy classification with associated pulmonary fibrosis using 3D attention-gated convolutional network with CT scans

Journal of Translational Medicine
Background Chest Computed tomography (CT) scans detect lung nodules and assess pulmonary fibrosis. While pulmonary fibrosis indicates increased lung cancer risk, current clinical practice characterizes nodule risk of malignancy based on nodule size and ...
Yucheng Liu, Hao Yun Hsu, Tiffany Lin, Boyu Peng, Anjali Saqi, Mary M. Salvatore, Sachin Jambawalikar   +6 more
doaj   +1 more source

Lung Nodule Detection In Ct Scans

, 2004
In this paper we describe a computer-aided diagnosis (CAD) system for automated detection of pulmonary nodules in computed-tomography (CT) images. After extracting the pulmonary parenchyma using a combination of image processing techniques, a region growing method is applied to detect nodules based on 3D geometric features. We applied the CAD system to
ANTONELLI, MICHELA, FROSINI, GRAZIANO, LAZZERINI, BEATRICE, MARCELLONI, FRANCESCO   +3 more
openaire   +4 more sources

circZNF148 Drives Glucose Metabolism Reprogramming to Enhance Metastasis and Immune Evasion via HK1 Stabilization in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin, Wenjing Zhao, Lei Wang, Jianing Wang, Keying Zhao, Dan Luo, Yifei Wang, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Xiaoyan Li, Bing Chen, Lijuan Wang, Yiran Liang, Qifeng Yang   +17 more
wiley   +1 more source

Pulmonary Nodule Segmentation Using Deep Learning: A Review

IEEE Access
Accurate segmentation of pulmonary nodule within medical imagery is of great significance for classification and diagnosis. This task is profoundly challenging due to scarcity of annotated data, the diversity of lung nodule features, and the complexity ...
Yong Wang, Seri Mastura Mustaza, Mohammad Syuhaimi Ab-Rahman   +2 more
doaj   +1 more source