Results 71 to 80 of about 1,490,261 (247)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Visualization of alveolar recruitment in a porcine model of unilateral lung lavage using 3He-MRI

, 2009
BACKGROUND: In the acute respiratory distress syndrome potentially recruitable lung volume is currently discussed. (3)He-magnetic resonance imaging ((3)He-MRI) offers the possibility to visualize alveolar recruitment directly.
Gast, K K, Schreiber, W. G., Schreiber, W G, Markstaller, K, David, M, Eberle, B, David, M., Eberle, B., Rudolph, A., Gast, K. K., Rudolph, A, Markstaller, Klaus   +11 more
core   +1 more source

Intestinal effects of lung recruitment maneuvers

, 2007
Background and aims: Lung recruitment maneuvers (brief episodes of high airway pressure) are a modern treatment alternative to achieve open lung conditions under mechanical ventilation of patients with acute lung injury.
Claesson, Jonas
core   +2 more sources

A Novel Noninvasive Tool to Assess Recruitability During Assisted VentilationTake-Home Points

CHEST Critical Care
Background: Lung recruitability refers to the capacity of lung parenchyma to regain aeration and functional units in response to increased airway pressure.
Luca Bastia, MD, Roberta Garberi, MD, Liliana Amendolagine, MD, Emanuele Russo, MD, Tommaso Mauri, MD, Giuseppe Foti, MD, Vanni Agnoletti, MD, Emanuele Rezoagli, MD, PhD   +7 more
doaj   +1 more source

Innate Immunity Induces the Accumulation of Lung Mast Cells During Influenza Infection

Frontiers in Immunology, 2018
Mast cells release disease-causing mediators and accumulate in the lung of asthmatics. The most common cause of exacerbations of asthma is respiratory virus infections such as influenza. Recently, we demonstrated that influenza infection in mice triggers
Behdad Zarnegar, Annika Westin, Syrmoula Evangelidou, Jenny Hallgren   +3 more
doaj   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Lung recruitment—A nurse and/or physician task

, 2009
International and national guidelines on requirements for performing lung recruitment manoeuvres are lacking. This paper presents a nationwide descriptive survey of the occurrence of and conditions for lung recruitment in adult patients treated with ...
Piltén, Carina,, Eldh, Ann Catrine,, Ann Catrine Eldh, Carina Piltén   +3 more
core   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

State of Ohio ... the employer of choice

, 2004
[Rev.].; Title from PDF cover (viewed Jan. 14, 2004).; "Hrd/rev8.30.04"--P. [4] of cover.; Harvested from the web on 1/14/05[Rev.]
Ohio. Centralized Recruitment Office
core