Results 61 to 70 of about 131,647 (261)

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Longitudinal Outcomes and Ribavirin Use in Lung Transplant Recipients with Respiratory Syncytial Virus or Human Metapneumovirus Infection: A Real-World Multicenter Cohort Study

Life
Respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) are clinically relevant pathogens in lung transplant (LT) recipients, but their impact on lung function and the benefit of ribavirin remains uncertain.
Miguel Jiménez-Gómez, Beatriz Montull-Veiga, Víctor Manuel Mora-Cuesta, Eva Revilla-López, Myriam Aguilar-Pérez, Alicia de-Pablo-Gafas, Juan Margallo-Iribarnegaray, Carlos Andrés Quezada-Loaiza, Ana Hernández-Voth, Francisco López-Medrano, María Ruiz-Rodríguez, Rodrigo Alonso-Moralejo   +11 more
doaj   +1 more source

Lung and heart-lung transplantation

Cardiology in the Young, 2009
I NCREASED UNDERSTANDING AND AWARENESS OF congenital cardiac disease has allowed early identification of these children. Advances in surgical techniques, anesthesia, and medical treatment have rendered the majority of forms of congenital cardiac defects treatable.
Date, Hiroshi, Sweet, Stuart C
openaire   +4 more sources

Self‐Assembling Copolymers Encapsulating Single Endothelial Cells Induce Endogenous ECM Deposition and Vascular Regeneration

Advanced Materials, EarlyView.
This study presents the first demonstration of stable sub‐50‐micron single‐cell GPM vesicles fabricated through the intrinsic self‐assembly of an amphiphilic copolymer. Hierarchical assembly of cell containing GPM vesicles into microspheres enable tunable, sustained cell delivery with immune protection.
Viola B. Morris, Sangho Lee, Kalp Soni, Simon He, Matthew Huang, Dandan Chen, Dae Hoon Lee, Kyung Hee Kim, Seonggeon Cho, Laura Pencea, Divit Jain, Young‐Sup Yoon   +11 more
wiley   +1 more source

Everolimus Treatment for Chronic Lung Allograft Dysfunction in Lung Transplantation

Life
Our study aims to evaluate the effect of everolimus treatment on lung function in lung transplant (LT) patients with established chronic lung allograft dysfunction (CLAD).
David Iturbe-Fernández, Alicia de Pablo Gafas, Víctor Manuel Mora Cuesta, Rodrigo Alonso Moralejo, Carlos Andrés Quezada Loaiza, Virginia Pérez González, Daniel López-Padilla, José M. Cifrián   +7 more
doaj   +1 more source

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

Tailored Personas for Lung Transplant Recipients’ Return-to-Work Experiences: A Secondary Analysis of Qualitative Data

Patient Preference and Adherence
Keyao Huang,1,* Shiyu Wang,1,* Linlin Cai,2 Zixuan Chen,3 Xiaodong Cao,1 Haiqin Zhou1 1The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi People’s Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi ...
Huang K, Wang S, Cai L, Chen Z, Cao X, Zhou H   +5 more
doaj  

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Physician perspectives on pulmonary hypertension in ILD: results of a cases-based survey

BMC Pulmonary Medicine
Background Pulmonary hypertension (PH) complicates the course of patients with interstitial lung disease (ILD) in 30–55% of cases and is associated with increased morbidity and mortality. The optimal timing of diagnostic right heart catheterization (RHC)
Ho Cheol Kim, Christopher S. King, Christopher Thomas, Vikramjit Khangoora, Osman Malik, Jared Wilkinson, Shambhu Aryal, Anju Singhal, Alan Nyquist, Oksana A. Shlobin, Steven D. Nathan   +10 more
doaj   +1 more source

Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis

Advanced Science, EarlyView.
Microglia replacement by bone marrow transplantation (Mr BMT) enables systemic replacement of tissue‐resident macrophages. Despite persistent macrophage and tissue remodeling across multiple organs, core biological functions and innate immune responses remain preserved, supporting long‐term maintenance of organismal homeostasis and the therapeutic ...
Yufei Xu, Miaozhan Zou, Yunshang Bai, Yang He, Zhihao Jin, Baozhi Yang, Jinjin Du, Pei Ouyang, Yuanyuan Cai, Yuheng Zhang, Bingying Du, Chengcheng Ge, Jian‐an Gong, Xiaoyu Li, Yuanyi Zheng, Jing Ding, Bo Peng, Yanxia Rao   +17 more
wiley   +1 more source