Results 71 to 80 of about 131,647 (261)

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source

Association of CD16hiCD62Llo Neutrophils with Disease Severity and Impact of SYK Inhibition in Sepsis

Journal of Inflammation Research
Xianglan Yao,1,2 Heather L Teague,1,2 Lauren E Knabe,1,2 Raquel Santana da Cruz,1,2 Trenton Williams,1,2 Merte Lemma Woldehanna,3 Ernest Evans,3 Amir Hobson,3 Jared D Wilkinson,3 Cumhur Yusuf Demirkale,2 Steven D Nathan,3 Christopher King,3 Jeffrey R ...
Yao X, Teague HL, Knabe LE, Santana da Cruz R, Williams T, Lemma Woldehanna M, Evans E, Hobson A, Wilkinson JD, Demirkale CY, Nathan SD, King C, Strich JR   +12 more
doaj  

Erratic tacrolimus levels at 6 to 12 months post-lung transplant predicts poor outcomes

JHLT Open
Background: It has previously been described that erratic tacrolimus blood levels are associated with graft failure in kidney and liver transplantation.
Samuel Walters, Stephanie Yerkovich, Peter M Hopkins, Trish Leisfield, Lesleigh Winks, Daniel C Chambers, Chandima Divithotawela   +6 more
doaj   +1 more source

Morbidity and mortality of serious gastrointestinal complications after lung transplantation

Journal of Cardiothoracic Surgery, 2019
Background Gastrointestinal complications after lung transplatation are associated with an increased risk of morbidity and mortality. This study aims to describe severe gastrointestinal complications (SGC) after lung transplantation. Methods We performed
Annette Zevallos-Villegas, Rodrigo Alonso-Moralejo, Félix Cambra, Ana Hermida-Anchuelo, Virginia Pérez-González, Pablo Gámez-García, Javier Sayas-Catalán, Alicia De Pablo- Gafas   +7 more
doaj   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

CMV Infection Following mRNA SARS-CoV-2 Vaccination in Solid Organ Transplant Recipients

Transplantation Direct, 2022
Shourjo Chakravorty, MD, Adam B. Cochrane, PharmD, MPH, Mitchell A. Psotka, MD, PhD, Anil Regmi, MD, Lauren Marinak, NP, Amy Thatcher, NP, Oksana A. Shlobin, MD, A. Whitney Brown, MD, Christopher S. King, MD, FCCP, Kareem Ahmad, MD, Vikramjit Khangoora, MD, Anju Singhal, MD, Steven D. Nathan, MD, FCCP, Shambhu Aryal, MD, FCCP   +13 more
doaj   +1 more source

UDP‐Glucose‐6‐Dehydrogenase Mediated O‐GlcNAcylation of Tight Junction Protein 1 Suppresses Metastasis in Renal Cell Carcinoma

Advanced Science, EarlyView.
Our research unveiled a regulatory paradigm wherein TRIM25 orchestrates the ubiquitin‐mediated degradation of UGDH. UGDH modulates the protein stability of TJP1 by regulating O‐GlcNAcylation levels, effectively impeding the metastasis of ccRCC. Our insights elevate UGDH to a pivotal biomarker and tumor suppressor, marking the first demonstration that ...
Xiaolin Chen, Yuhang Bao, Tao Liu, Jianhui Qiu, Yuanyuan Ma, Zedan Zhang, Chuandong Wang, Ruiyi Deng, Zheng Song, Tianyi He, Haode Liu, Jingcheng Zhou, Yizhou Wang, Kan Gong   +13 more
wiley   +1 more source

Transplantation of the lung

Transplantation, 1964
J L, TITUS, R G, SHORTER, W S, PAYNE
openaire   +5 more sources

Chiral Nanoparticles Suppress Inflammatory Infiltration to Promote Extracellular Matrix Remodeling for Ectopia Lentis Therapy

Advanced Science, EarlyView.
L‐cysteine‐configured chiral polyurethane nanoparticles suppress ocular inflammation and reduce extracellular matrix (ECM) degradation in ectopia lentis by regulating macrophages polarization and inhibiting nuclear factor kappa B signaling pathway. By promoting zonular fiber‐associated protein restoration and tissue repair, this minimally invasive ...
Yinuo Wen, Yan Yang, Haihan Gao, Yan Liu, Xinyue Wang, Linghao Song, Ruohong Li, Ao Miao, Jie Xu, Zhennan Zhao, Dan Li, Shenjie Peng, Linzhao Li, Min Zhang, Yonghang Liu, Liren Wang, Tianhui Chen, Yongxiang Jiang   +17 more
wiley   +1 more source