Results 121 to 130 of about 3,067,002 (353)

Anti‐Apoptotic and Neurite‐Protective Nanomedicine Augments Embryonic Stem Cells‐Derived Retinal Ganglion Cell Transplantation in Glaucoma Recovery

Advanced Science, EarlyView.
Lithium‐epigallocatechin gallate nanoparticles (Li‐EGCG NPs) are co‐transplanted with embryonic stem cell‐derived retinal ganglion cells (ESC‐RGCs) to enhance cell survival and therapeutic efficacy in an acute pathological glaucomatous injury model. This synergistic approach protects RGC cells, preserves retinal structure and improves visual function ...
Moxin Chen, Xiaoyan Jiang, Yuanhui Wang, Zhaobin Luo, Yu Zhang, Siwei Liu, Rui Huang, Dandan Zhang, Zhimin Tang, Yahan Ju, Shaohui Pan, Ni Ni, Wei Feng, Yu Chen, Ping Gu   +14 more
wiley   +1 more source

Antireflux surgery for prevention of chronic lung allograft dysfunction (CLAD) onset after lung transplantation: The earlier the better before CLAD onset? A single-center series of 284 patients

JHLT Open
Background: Gastroesophageal reflux disease (GERD) is highly prevalent after lung transplantation (LTx) and is suspected to favor the development of chronic lung allograft dysfunction (CLAD), almost of bronchiolitis obliterans syndrome (BOS) phenotype ...
Abdulmonem Hamid, Alexandre Vallée, Sophie Rong, Olivier Boche, Sandra De Miranda, Laurence Beaumont-Azuar, Sylvie Colin de Verdière, Dominique Grenet, Marc Stern, Benjamin Zuber, Jerôme Devaquet, Julien Fessler, Julien De Wolf, Ciprian Pricopi, Matthieu Glorion, Edouard Sage, Jonathan Messika, Antoine Magnan, François Parquin, Clément Picard, Antoine Roux, Olivier Brugière   +21 more
doaj   +1 more source

Epidemiology of invasive aspergillosis in critically ill patients : clinical presentation, underlying conditions, and outcome [PDF]

, 2015
Introduction: Invasive aspergillosis (IA) is a fungal infection that particularly affects immunocompromised hosts. Recently, several studies have indicated a high incidence of IA in intensive care unit (ICU) patients.
Blasco-Navalpotro, Miguel, Blot, Stijn I, Bulpa, Pierre, Cardoso, Teresa, De Laere, Emmanuel, Dimopoulos, George, Meersseman, Wouter, Misset, Benoit, Paiva, José-Artur, Rello, Jordi, Taccone, Fabio Silvio, Universitat Autònoma de Barcelona, Van den Abeele, Anne-Marie, Vogelaers, Dirk   +13 more
core   +3 more sources

DCAF13 Safeguards Hematopoietic Stem Cells via RRS1‐Regulated Ribosome Biogenesis

Advanced Science, EarlyView.
This study establishes DCAF13 as an essential regulator for hematopoietic stem cell (HSC) function. Its deletion in mice causes lethal pancytopenia and HSC depletion. Mechanistically, DCAF13 interacts with RRS1 and mediates its non‐degradative K27‐linked ubiquitination, thereby stabilizing RRS1 to maintain ribosome biogenesis and protein translation ...
Mengke Li, Yuxin Wu, Shuai Zhou, Peipei Tang, Jiaming Wei, Ling Liu, Zhenyi Wang, Deyang Shi, Shengnan Yuan, Qingyu Zhang, Shihui Wang, Qing Zhang, Huan Zhao, Rui Zhang, Yingying Wang, Shiwei Yang, Xiangli Chen, Xiaojing Shi, Guangzhi Liu, Yuwei Zhang, Jinming Li, Xu Dong Zhang, Rick F Thorne, Dongping Wei, Zumin Zhu, Song Chen   +25 more
wiley   +1 more source

Heart-Lung Transplantation

Clinics in Chest Medicine, 1990
The results of combined heart-lung transplantation have continued to improve following its reintroduction into clinical practice in 1981. En-bloc implantation has an apparent protective effect on subsequent tracheal anastomotic healing. Continuing developments in immunosuppression, rejection surveillance, and organ preservation will allow the procedure
R S, Bonser, S W, Jamieson
openaire   +3 more sources

Case Report: Low-profile covered stents in CHD: the role of Gore Viabahn (VBX) stents

Frontiers in Pediatrics
The Gore Viabahn covered stent, approved for the treatment of peripheral arterial disease in femoral or iliac artery lesions, may offer advantageous features in the field of congenital heart diseases.
Micol Rebonato, Catarina Almeida, Mara Pilati, Enrico Piccinelli, Gianfranco Butera   +4 more
doaj   +1 more source

Historic landmarks in clinical transplantation: Conclusions from the consensus conference at the University of California, Los Angeles [PDF]

, 2000
The transplantation of organs, cells, and tissues has burgeoned during the last quarter century, with the development of multiple new specialty fields.
Brent, LB, Calne, RY, Dausset, JB, Good, RA, Groth, CG, Murray, JE, Schwartz, RS, Shumway, NE, Starzl, TE, Terasaki, PI, Thomas, ED, Van Rood, JJ   +11 more
core   +1 more source

Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan, Zorica Petrovic, M. Sadman Sakib, Sophie Schröder, Dennis Manfred Krüger, Tonatiuh Pena, Eren Diniz, Susanne Burkhardt, Anna‐Lena Schütz, Verena Gisa, Iga Grzadzielewska, Karl Toischer, Thor D. Stein, Jan Krzysztof Blusztajn, Ivana Delalle, Jelena Radulovic, Farahnaz Sananbenesi, Andre Fischer   +17 more
wiley   +1 more source

Activated Platelet–Released Heat Shock Protein 90α Triggers Autophagy‐Dependent Neutrophil Extracellular Trap Formation and Amplifies Sepsis

Advanced Science, EarlyView.
HSP90α is significantly upregulated in platelets from sepsis patients, with its origin from megakaryocyte‐derived trafficking. Furthermore, activated platelets secrete HSP90α into the extracellular space in both free and exosome‐associated forms. Finally, extracellular HSP90α directly engages TLR4 on neutrophils to induce autophagy, leading to NET ...
Chengbo Wang, Maodong Leng, Chenchen Sun, Jingyu Cao, Linfei Li, Yangyang Jia, Yongshuai Han, Yuchun Liu, Yaodong Zhang, Chenglong Zhang, Yingli Men, Ningyuan Liu, Yibing Cheng, Yixia Zhang, Ya Li, Zhenlong Li, Lidan Cui, Xiangzhan Zhu   +17 more
wiley   +1 more source

Risk factors for unplanned intensive care unit admission after esophagectomy: a retrospective cohort study of 628 patients with esophageal cancer

Frontiers in Oncology
IntroductionEsophagectomy patients who experience unplanned ICU admission (UIA) may experience a heavier economic burden and worse clinical outcomes than those who experience routine intensive care unit (ICU) admission.
Guoqing Zhang, Shaowu Sun, Zhengxia Dong, Huang Chunyao, Zhulin Wang, Kaiyuan Li, Xu Liu, Yujie Zhang, Junya Wang, Jindong Li, Jia Zhao, Xiangnan Li   +11 more
doaj   +1 more source