Results 111 to 120 of about 1,460,646 (299)

Low SLC8A1 in Colorectal Cancer Dictates Radiotherapy Resistance Through Calcium‐Dependent ANXA2+sEVs Driving M2 Polarization of TAMs

Advanced Science, EarlyView.
SLC8A1 deficiency in colorectal cancer cells increases intracellular calcium signaling, promoting the secretion of ANXA2‐enriched small extracellular vesicles. These vesicles reprogram tumor‐associated macrophages towards an M2 phenotype, which in turn fosters a tumor microenvironment conducive to radioresistance and is associated with poor patient ...
Yimin Fang, Jinghan Zhu, Qian Xiao, Qichun Wei, Xiujing He, Ping Li, Kai Jiang, Yue Liu, Yeting Hu, Weiwei Yu, Chuansheng Guo, Sheng Chen, Jian Zhao, Siqi Dai, Jingsun Wei, Hang Yang, Tongtong Bu, Kefeng Ding, Haiyan Chen   +18 more
wiley   +1 more source

Inorganic Nanomaterials can Promote or Inhibit Tumor Metastasis Depending on Tumor Microenvironment Composition

Advanced Science, EarlyView.
As engineered nanomaterials gain prominence in cancer imaging and therapy, understanding their impact on tumor progression becomes increasingly critical. We demonstrate that gold and silica‐coated gold nanomaterials can either suppress or enhance breast cancer metastasis through distinct tumor microenvironment interactions, while identifying ...
Kiana Buttiens, Xiaoqi Zheng, Xueqi Fan, Mukaddes Izci, Christy Maksoudian, Irati Perez Gilabert, Tianjiao Chu, Filipa Goncalves, Jonas Dehairs, Johan Swinnen, Bella B. Manshian, Stefaan J. Soenen   +11 more
wiley   +1 more source

The Effect of Ideal/Standard Donor and Marginal Donor Use on Primary Graft Dysfunction After Lung Transplantation in Turkey

Eurasian Journal of Medicine, 2023
Sinan Türkkan , Emre Yılmaz, Mustafa Bindal , Fatmanur Çelik Başaran , Mehmet Furkan Şahin , Muhammet Ali Beyoğlu , Alkın Yazıcıoğlu , Erdal Yekeler   +7 more
doaj   +1 more source

Airway epithelium in lung transplantation: a potential actor for post-transplant complications?

European Respiratory Review
Lung transplantation, a critical intervention for end-stage lung diseases, is frequently challenged by post-transplant complications. Indeed, primary graft dysfunction, anastomotic complications, infections and acute and chronic rejections pose ...
Jules Milesi, Delphine Gras, Pascal Chanez, Benjamin Coiffard   +3 more
doaj   +1 more source

The impact of gastrointestinal dysmotility on the aerodigestive microbiome of pediatric lung transplant recipients

, 2020
BACKGROUND:Delayed gastric emptying has been associated with increased graft rejection, althoughthe mechanism of this association is not known. This study aims to investigate the interrelationshipbetween delays in gastrointestinal motility and the ...
Lurie, Margot,, Rosen, Rachel, Lötstedt, Britta,, Boyer, Debra,, Kane, Madeline,, Setchell, Kenneth,, Lundeberg, Joakim,, Visner, Gary,, Narvaez-Rivas, Monica,, Alm, Eric,, Freiberger, Dawn,, DiFilippo, Courtney,   +11 more
core  

A Microenvironment‐Adaptive Scaffold Rejuvenates Peripheral Nerve Regeneration During Aging Via Dual Modulation of Ferroptotic Stimuli in Schwann Cells

Advanced Science, EarlyView.
(i) Aging impairs peripheral nerve regeneration via its dual ferroptosis‐mediated pathologies in senescent schwann cells. (ii) The composite nerve conduit is a symbiosis niche integrating microenvironment‐responsive nanoparticles (Ga‐PTAs) and maxillofacial‐derived mesenchymal stem cells (Mmscs).
Ning Zhan, Lixin Tian, Lianjie Peng, Jingyu Zhang, Lining Lin, Xiaoting Zhang, Yaxian Luo, Zhichao Liu, Xinhua Yao, Mouyuan Sun, Yong He, Mengfei Yu, Huiming Wang   +12 more
wiley   +1 more source

An integrated strategy for reducing anastomotic leakage in patients undergoing McKeown esophagectomy

Heliyon
Objective: To describe our experience of reducing anastomotic leakage, a problem that has not been properly solved. Methods: Starting in January 2020, we began implementing our integrated strategy (application of an esophageal diameter-approximated ...
Yan Zhang, Junya Wang, Shuang Ren, Jia Jiao, Zheng Ding, Hang Yang, Dabo Pan, Jindong Li, Guoqing Zhang, Xiangnan Li, Song Zhao   +10 more
doaj   +1 more source

Tissue‐Agnostic Cellular Morphometric Biomarkers for Risk‐Adapted Management Across Gastrointestinal Precancerous Lesions and Cancers

Advanced Science, EarlyView.
An interpretable, unsupervised artificial intelligence framework identifies a 13‐cellular morphometric biomarker (CMB) signature from routine H&E whole‐slide images. Validated across 2,602 patients, the fixed signature generalizes across colorectal, gastric, and esophageal tissues without retraining, stratifies prognosis and precancerous lesion risk ...
Pin Wang, Chengfei Jiang, April W. Mao, Qi Sun, Yijun Lu, Jingjing Wei, Jamie L. Inman, Susan E. Celniker, Antoine M. Snijders, David W. Threadgill, Allan Balmain, Bo Hang, Hang Chang, Lei Wang, Jian‐Hua Mao   +14 more
wiley   +1 more source

Immune function in a patient with aspergillosis after lung transplantation: Case Report [PDF]

, 2012
We report a case that was successfully treated invasive pulmonary aspergillosis after living donor lobar lung transplantation and monitored patients' immune function with ImmuKnow® assay.
Nagayasu, Takeshi, Miyazaki, Takuro, Matsumoto, Keitaro, Tsuchihashi, Yoshiko, Morimoto, Konosuke, Tsuchiya, Tomoshi, Yamasaki, Naoya, Tagawa, Tsutomu, Tomoshige, Koichi   +8 more
core  

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source