Results 91 to 100 of about 350,824 (326)
Clinics, 2011 OBJECTIVE: To determine whether preoperative inspiratory muscle training is able to attenuate the impact of surgical trauma on the respiratory muscle strength, in the lung volumes, and diaphragmatic excursion in obese women undergoing open bariatric ...
Marcela Cangussu Barbalho-Moulim +4 more
doaj +1 more source
Repeatability of small lung nodule measurement in low-dose lung screening: a phantom study
BMC Medical Imaging, 2020 Background Lung cancer screening revealed that people with small pulmonary nodules are mostly asymptomatic and that some of these people are at risk of developing lung cancer, so we intended to explore the repeatability of small lung nodule measurement ...
Yu Du +4 more
doaj +1 more source
Exercise-induced whole-body dehydration does not affect airway responsiveness in athletes but may impair small airway function [PDF]
, 2015 Exercise-induced bronchoconstriction (EIB) is the transient narrowing of the airways that occurs during or shortly after strenuous exercise. Loss of water from the airway surface, due to the conditioning of large volumes of air during exercise, is the ...
Kippelen, P, Romer, L, Simpson, A
core +1 more source
Accurate,robust and harmonized implementation of morpho-functional imaging in treatment planning for personalized radiotherapy [PDF]
, 2019 In this work we present a methodology able to use harmonized PET/CT imaging in dose painting by number (DPBN) approach by means of a robust and accurate treatment planning system.
Baeza, José Antonio +8 more
core +2 more sources
Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Critical Care, 2018 Background High frequency percussive ventilation (HFPV) combines diffusive (high frequency mini-bursts) and convective ventilation patterns. Benefits include enhanced oxygenation and hemodynamics, and alveolar recruitment, while providing hypothetic lung-
Thomas Godet +9 more
doaj +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
The Egyptian Journal of Radiology and Nuclear Medicine, 2016 Purpose: To analyze the correlation and agreement between three dimensional (3D) US and MRI in the assessment of pulmonary volumes of fetuses with different types of urinary tract malformations (UTM) and high-risk of pulmonary hypoplasia (PH).
Mariam Raafat +2 more
doaj +1 more source
, 2012 OBJECTIVE: Ventilator-induced lung injury is a crucial determinant of the outcome of mechanically ventilated patients. Increasing numbers of mouse studies have identified numerous pathways and mediators that are modulated by ventilation, but it is ...
Patel, BV, Takata, M, Wilson, MR
core +1 more source