Results 241 to 250 of about 172,941 (311)

Photoactivated Proximity Protein Labeling Reveals Enhanced Tumor Retention of a D‐Peptide‐Ruthenium Prodrug Conjugate

Advanced Healthcare Materials, EarlyView.
Six stereoisomeric ruthenium‐peptide conjugates were synthesized and characterized, which showed high potential in photoactivated chemotherapy (PACT) and proximity protein labeling. Abstract Amino acid chirality is known to influence the biological properties of peptide‐containing prodrugs.
Liyan Zhang, Peiyuan Wang, Hildert Bronkhorst, Yurii Husiev, Ludovic Bretin, Maarten N. van Ginkel, Wen Sun, Sylvestre Bonnet   +7 more
wiley   +1 more source

Silencing Myostatin Using In Vivo Self‐Assembled siRNA Protects Against Cancer‐ and Dexamethasone‐Induced Muscle Atrophy

Advanced Healthcare Materials, EarlyView.
This study reports an in vivo self‐assembled siRNA strategy that enables the liver to generate small extracellular vesicles (sEVs) tagged with a muscle‐targeting peptide (MSP) and naturally loaded with myostatin (MSTN)‐siRNA. These MSP‐tagged sEVs are systemically delivered to skeletal muscle, efficiently silence MSTN, promote muscle hypertrophy, and ...
Xin Yin, Azhar Anwar, Jiehao Chen, Qinghao Sun, Likun Zhou, Jie Tang, Jingwei Guo, Linbo Yan, Yongci Chen, Feng Yin, Chen‐Yu Zhang, Zigang Li, Jizheng Ma, Liyuan Sheng, Xi Chen   +14 more
wiley   +1 more source

Automatic delineation of functional lung volumes with ⁶⁸Ga-ventilation/perfusion PET/CT. [PDF]

EJNMMI Res, 2017
Le Roux PY, Siva S, Callahan J, Claudic Y, Bourhis D, Steinfort DP, Hicks RJ, Hofman MS.   +7 more
europepmc   +1 more source

Biomimetic Mineralization of Keratin Scaffolds for Enamel Regeneration

Advanced Healthcare Materials, EarlyView.
Keratin‐based films guide biomimetic enamel remineralization by promoting organized hydroxyapatite growth under physiological conditions. Advanced biophysical characterization confirms keratin's structural adaptability and mineral ions‐binding affinity, supporting mineral nucleation and hierarchical crystal assembly. This study establishes keratin as a
Sara Gamea, Elham Radvar, Dimitra Athanasiadou, Ryan Lee Chan, Giacomo De Sero, Ecaterina Ware, Sunie Kundi, Avir Patel, Shwan Horamee, Shuaib Hadadi, Mads Carlsen, Leanne Allison, Roland Fleck, Ka Lung Andrew Chan, Avijit Banerjee, Nicola Pugno, Marianne Liebi, Paul T Sharpe, Karina Carneiro, Sherif Elsharkawy   +19 more
wiley   +1 more source

Lung volumes and lung volume recruitment in ARDS: a comparison between supine and prone position. [PDF]

Ann Intensive Care, 2018
Aguirre-Bermeo H, Turella M, Bitondo M, Grandjean J, Italiano S, Festa O, Morán I, Mancebo J.   +7 more
europepmc   +1 more source

Seeing inside the Body Using Wearable Sensing and Imaging Technologies

Advanced Healthcare Materials, EarlyView.
This review explores wearable technologies for noninvasive internal health monitoring. It categorizes approaches into indirect sensing (e.g., bioelectrical and biochemical signals) and direct imaging (e.g., wearable ultrasound and EIT), highlighting multimodal integration and system‐level innovation toward personalized, continuous healthcare.
Sumin Kim, Seunghun Han, Sehwan Park, Jahyun Koo   +3 more
wiley   +1 more source

Supine posture changes lung volumes and increases ventilation heterogeneity in cystic fibrosis. [PDF]

PLoS One, 2017
Smith LJ, Macleod KA, Collier GJ, Horn FC, Sheridan H, Aldag I, Taylor CJ, Cunningham S, Wild JM, Horsley A.   +9 more
europepmc   +1 more source

The residual volume (RV) and total lung capacity (TLC) in percentage of predicted volumes for the first and second pulmonary function tests as boxplots of the median and interquartile ranges with lines between indicating the individual changes.

, 2015
James D. Tutor, Saumini Srinivasan, Memorie M. Gosa, Thomas Spentzas, Dennis C. Stokes   +4 more
openalex   +1 more source

Cyclic Peptide–Polymer Conjugate Nanotubes for Delivery of SN‐38 in Treatment of Colorectal Cancer Model

Advanced Healthcare Materials, EarlyView.
This study develops cyclic peptidepolymer conjugate nanotubes with hydrophobic, drug‐rich cores to enhance drug loading and stability, and demonstrates their responsive disassembly, pharmacokinetics, and anti‐tumour efficacy in colorectal cancer models using the anticancer drug SN‐38.
Sophie K. Hill, Min Zeng, Santhosh Kalash Rajendrakumar, Robert Dallmann, Sébastien Perrier   +4 more
wiley   +1 more source

Transforming Cancer Diagnosis and Therapy Through Fluorescent Hydrogels: A Review

Advanced Healthcare Materials, EarlyView.
This article reviews fluorescent hydrogel systems for cancer detection, monitoring, and therapy. Mimicking the tumor microenvironment, these hydrogels enable real‐time imaging and targeted drug delivery. The review discusses design strategies, labeling techniques, and applications, highlighting challenges and future opportunities in cancer diagnostics ...
Elahe Masaeli, Seshasai Srinivasan, Amin Reza Rajabzadeh   +2 more
wiley   +1 more source