Results 291 to 300 of about 2,323,446 (365)

The impact of PET/CT scanning on the size of target volumes, radiation exposure of organs at risk, TCP and NTCP, in the radiotherapy planning of non-small cell lung cancer

, 2013
̈Radovan Vojtíšek, Jan Mužı́k, Pavel Šlampa, Marie Budı́ková, Jaroslav Hejsek, Petr Smolák, Jiří Ferda, Jindřich Fínek   +7 more
openalex   +1 more source

Membrane Fusion‐Inspired Nanomaterials: Emerging Strategies for Infectious Disease and Cancer Diagnostics

Advanced Healthcare Materials, EarlyView.
Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee, Khulan Nyamzaya, Jueun Han, Yejin Song, Jihee Lee, Jung Hyun Jo, Seungmin Bang, Eun‐Kyung Lim, Seungjoo Haam, Eunjung Kim   +9 more
wiley   +1 more source

Nanobody‐Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo

Advanced Healthcare Materials, EarlyView.
This study presents a targeted mRNA‐LNP platform engineered with anti‐PSMA nanobodies for prostate cancer therapy. Using different in vivo models, the authors demonstrate selective uptake and mRNA delivery in PSMA+ cancer cells. However, while targeting is enhanced, mRNA delivery efficacy is limited by tissue penetration, tumor necrosis, and immune ...
Pol Escudé Martinez de Castilla, Vincenzo Verdi, Willemijn de Voogt, Mariona Estapé Sentí, Arnold C. Koekman, Julian Rietveld, Sven van Kempen, Qiangbing Yang, Juliette van Merris, Guido Jenster, Martin E. van Royen, Marcel H. Fens, Sander A. A. Kooijmans, Wytske M. van Weerden, Guillaume van Niel, Pieter Vader, Raymond M. Schiffelers   +16 more
wiley   +1 more source

Pulmonary Delivery of siRNA Anti‐TNFα‐loaded Lipid Nanoparticles for Rapid Recovery in Murine Acute Lung Injury

Advanced Healthcare Materials, EarlyView.
In a murine model of acute lung injury, pulmonary administration of lipid nanoparticles carrying TNFα siRNA enables targeted delivery to immune cells. The study emphasises the importance of optimizing LNP distribution and delivery timing to improve therapeutic outcomes and develop emergency therapies for lung hyperinflammation.
Qinglin Wang, Jihana Achour, Laila Emam, Younes Louaguenouni, Catherine Cailleau, Françoise Mercier‐Nomé, Séverine Domenichini, Claudine Delomenie, Sezen Gul, Juliette Vergnaud, Nicolas Tsapis, Arnaud Mansart, Djillali Annane, Francois Fay, Elias Fattal   +14 more
wiley   +1 more source

Progress of Immune‐Inducible Biomaterials for Post‐Ablation Cancers

Advanced Healthcare Materials, EarlyView.
The presence of residual tumors after ablative therapies poses a significant challenge, generally resulting in recurrence and metastases. This review offers a concise overview of immune‐inducible biomaterials from the perspective of the cancer‐immunity cycle, and how they enhance antitumor immunity through diverse mechanisms following ablative ...
Shuangshuang Zhao, Zheng Zhang, Xincai Wu, Yanwei Chen, Wenjun Li, Jiayan Bao, Xin Zhang, Baoding Chen   +7 more
wiley   +1 more source

FDG-PET/CT imaging for tumor staging and definition of tumor volumes in radiation treatment planning in non-small cell lung cancer

, 2014
Yuanda Zheng, Xiaojiang Sun, Jian Wang, Lingnan Zhang, Xiaoyun Di, Yaping Xu   +5 more
openalex   +2 more sources

Mechanobiologically Engineered Mimicry of Extracellular Vesicles for Improved Systemic Biodistribution and Anti‐Inflammatory Treatment Efficacy in Rheumatoid Arthritis

Advanced Healthcare Materials, EarlyView.
Triblock copolymer‐reinforced liposomal mimics of extracellular vesicles are engineered with tunable membrane elasticity. A semi‐elastic formulation (Tri‐ARTEX8:2) co‐encapsulating stem cell cytosolic extract and AntagomiR155 targets inflamed joints via the ELVIS effect, reprograms macrophages from M1 to M2, and markedly alleviates collagen‐induced ...
Dahwun Kim, Hwira Baek, Su Yeon Lim, Min Sang Lee, Siyan Lyu, Jihyun Lee, Tun Naw Sut, Marta Gonçalves, Jeong Yi Kang, Joshua A. Jackman, Jin Woong Kim, Ji Hoon Jeong   +11 more
wiley   +1 more source

Automatic delineation of functional lung volumes with ⁶⁸Ga-ventilation/perfusion PET/CT. [PDF]

EJNMMI Res, 2017
Le Roux PY, Siva S, Callahan J, Claudic Y, Bourhis D, Steinfort DP, Hicks RJ, Hofman MS.   +7 more
europepmc   +1 more source

Comparative evaluation of hemodynamic and respiratory parameters during mechanical ventilation with two tidal volumes calculated by demi-span based height and measured height in normal lungs

, 2014
Mohammad Golparvar, LMousavi Seresht, Ahmad Yaraghi   +2 more
openalex   +1 more source

Multifunctional Biomedical Devices with Closed‐Loop Systems for Precision Therapy

Advanced Healthcare Materials, EarlyView.
This review explores two major types of closed‐loop therapeutic systems: self‐sustained and externally triggered. It highlights recent advances in stimuli‐responsive materials, integrated bioelectronics, and data‐driven control strategies, offering insight into emerging strategies for personalized, responsive drug delivery.
Yixuan Leng, Rujie Sun
wiley   +1 more source