ZusammenfassungDer kutane Lupus erythematodes manifestiert sich mit oder ohne systemische Beteiligung mit einem breiten klinischen Spektrum. Die Pathogenese der Erkrankung ist durch einen Toleranzverlust gegenüber körpereigenen Antigenen und einer chronisch schubweisen Aktivierung des angeborenen und adaptiven Immunsystems geprägt.
Claudia, Günther, Jörg, Wenzel
openaire +2 more sources
KITD816V+ systemic mastocytosis associated with KITD816V+ acute erythroid leukaemia: first case report with molecular evidence for same progenitor cell derivation [PDF]
Toll-like receptor (TLR)-9 recognizes CpG motifs in microbial DNA. TLR9 signalling stimulates innate antimicrobial immunity and modulates adaptive immune responses including autoimmunity against chromatin, e.g., in systemic lupus erythematosus (SLE ...
H-P Horny +4 more
core +1 more source
Cancer complicating systemic lupus erythematosus--a dichotomy emerging from a nested case-control study [PDF]
We determined whether any individual cancers are increased or decreased in a cohort of 595 patients with systemic lupus erythematosus (SLE) followed for up to 32 years at the University College London Hospitals Lupus Clinic, looking for any associated ...
Dey, D, Isenberg, DA, Kenu, E
core +1 more source
Efficacy and safety of rituximab in the treatment of eosinophilic granulomatosis with polyangiitis
Introduction Eosinophilic granulomatosis with polyangiitis (EGPA) is a subset of antineutrophil cytoplasmic antibodies (ANCA) associated vasculitis with distinct pathophysiological mechanisms, clinical features and treatment responses.
David Jayne +4 more
doaj +1 more source
Squeezed between shells? On the origin of the Lupus I molecular cloud. - II. APEX CO and GASS HI observations [PDF]
Accepted for publication in a future issue of Astronomy & Astrophysics. Reproduced with permission from Astronomy & Astrophysics. © 2018 ESO.Context. The Lupus I cloud is found between the Upper-Scorpius (USco) and the Upper-Centaurus-Lupus (UCL) sub ...
A. Burkert +58 more
core +3 more sources
Objective This study was conducted with sera from patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and arthritis and lupus-like disease animal models to identify innate immune system-dependent and -independent ...
Burmester, G. +5 more
core +2 more sources
Prophylactic inhibition of soluble epoxide hydrolase delays onset of nephritis and ameliorates kidney damage in NZB/W F1 mice [PDF]
Epoxy-fatty-acids (EpFAs), cytochrome P450 dependent arachidonic acid derivatives, have been suggested to have anti-inflammatory properties, though their effects on autoimmune diseases like systemic lupus erythematosus (SLE) have yet to be investigated ...
Dragun, Duska +9 more
core +2 more sources
SummaryCutaneous lupus erythematosus can manifest with or without systemic involvement resulting in a broad clinical spectrum. Disease pathogenesis is often characterized by a loss of tolerance to endogenous antigens and a chronic relapsing activation of the innate and adaptive immune system.
Günther, Claudia, Wenzel, Jörg
openaire +3 more sources
Hydroxychloroquine availability during COVID-19 crisis and its effect on patient anxiety
Objective To report the results of a survey exploring the experience of patients with SLE facing hydroxychloroquine (HCQ) shortage that occurred during the early phases of the COVID-19 pandemic.Methods A survey was designed by Lupus Europe’s patient ...
Alain Cornet +3 more
doaj +1 more source
Individualized decision aid for diverse women with lupus nephritis (IDEA-WON): A randomized controlled trial. [PDF]
BackgroundTreatment decision-making regarding immunosuppressive therapy is challenging for individuals with lupus. We assessed the effectiveness of a decision aid for immunosuppressive therapy in lupus nephritis.Methods and findingsIn a United States ...
Alarcón, Graciela S +27 more
core +2 more sources

