Lenalidomide Therapy in Treatment Refractory Cutaneous Lupus Erythematosus: Histologic and Circulating Leukocyte Profile and Potential Risk of a Systemic Lupus Flare [PDF]
Background Lenalidomide is a thalidomide analogue that may serve as an adjunctive therapy for treatment refractory cutaneous lupus erythematosus (CLE). Objectives We evaluate the use of lenalidomide in CLE and describe the skin and circulating leukocyte
Braunstein, Inbal+8 more
core +2 more sources
Rowell's syndrome in an Indian male and review of the literature
Lupus erythematosus (LE) with erythema multiforme-like lesions with its characteristic serological picture had been described in 1963. We report a 33-year-old married male who presented with skin lesions of various morphology on different body parts ...
Bhushan Madke, Uday Khopkar
doaj +1 more source
Hair Regrowth in Alopecia Areata. This scheme summarizes recent findings in hair follicle stem cell biology and their implication to regrow hair in alopecia areata. Hair follicle stem cells reside in hair bulge abundantly. Anagen drivers are enhanced and suppressed expression levels of activators and repressors at telogen, respectively.
Hiroki L. Yamaguchi+2 more
wiley +1 more source
COMO: A Pipeline for Multi-Omics Data Integration in Metabolic Modeling and Drug Discovery [PDF]
Identifying potential drug targets using metabolic modeling requires integrating multiple modeling methods and heterogenous biological datasets, which can be challenging without sophisticated tools. We developed COMO, a user-friendly pipeline that integrates multi-omics data processing, context-specific metabolic model development, simulations, drug ...
arxiv
Lupus Erythematosus: A Clinical Study of Seventy-One Cases [PDF]
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Balean, H., Sequeira, James H.
core +1 more source
Deformation of a biconcave-discoid capsule in extensional flow and electric field [PDF]
Biconcave-discoid (empirical shape of a red blood cell) capsule finds numerous applications in the field of bio-fluid dynamics and rheology, apart from understanding the behavior of red blood cells (RBC) in blood flow. A detailed analysis is, therefore, carried out to understand the effects of the uniaxial extensional flow and electric field on the ...
arxiv +1 more source
Classifying discoid lupus erythematosus: background, gaps, and difficulties
To inform our ongoing efforts to develop defining features to be incorporated into a novel set of classification criteria for discoid lupus erythematosus (DLE), we conducted a literature review using the Ovid MEDLINE database.
Jessica S. Haber, BA+2 more
doaj
Heat Map of Disease‐Protein and Disease‐Gene Associations. Context‐aware semantic online analytical processing (CaseOLAP) scores are represented across the Maternal Proteins and Genes (MPGs) on the x‐axis and the six Diseases of Interest (DOIs) on the y‐axis. Higher scores are depicted by darker cells.
Jacqueline G. Urdang+8 more
wiley +1 more source
Validation of the new classification criteria for systemic lupus erythematosus on a patient cohort from a national referral center: a retrospective study [PDF]
Aim To validate Systemic Lupus International Collaborating Clinics (SLICC)-12 and American College of Rheumatology (ACR)-97 classification criteria on a patient cohort from the University Hospital Center Zagreb.
Branimir Anić+2 more
core +2 more sources
Lupus erythematosus panniculitis in pregnancy
A case of lupus erythematosus (LE) panniculitis in pregnancy without any lesions of discoid LE or systemic LE is being reported. There were no systemic symptoms.
Swati Gondane+3 more
doaj +1 more source