Results 51 to 60 of about 137,248 (208)

Successful use of anifrolumab in refractory cutaneous lupus erythematosus with systemic lupus erythematosus: A case report

SAGE Open Medical Case Reports
A 61-year-old female with systemic lupus erythematosus presented with refractory discoid lupus. Despite treatment with numerous immunosuppressive therapies, including prednisone, hydroxychloroquine and mycophenolate mofetil, her cutaneous lupus remained ...
Abdullah Ramadhan, Anita Troung, Elaine Yacyshyn, Robert Gniadecki   +3 more
doaj   +1 more source

Brief Report: Pharmacodynamics, Safety, and Clinical Efficacy of AMG 811, a Human Anti–Interferon‐γ Antibody, in Patients With Discoid Lupus Erythematosus

Arthritis & Rheumatology, 2017
Interferon‐γ (IFNγ) is implicated in the pathogenesis of discoid lupus erythematosus (DLE). This study sought to evaluate a single dose of AMG 811, an anti‐IFNγ antibody, in patients with DLE.
V. Werth, D. Fiorentino, B. Sullivan, M. Boedigheimer, Kit Chiu, Christine Wang, G. E. Arnold, M. Damore, J. Bigler, A. Welcher, C. Russell, David A. Martin, James B. Chung   +12 more
semanticscholar   +1 more source

Multi‐omic profiling reveals immune cell priming signature linked to lupus prognosis

Arthritis &Rheumatology, Accepted Article.
Objective Systemic lupus erythematosus (SLE) is a multi‐organ disease with widespread immune dysregulation and significant unmet clinical need. Blood‐based gene expression studies have advanced our understanding of SLE pathogenesis but may overlook critical tissue‐specific mechanisms that drive disease heterogeneity and progression.
Michael A. Smith, Dominic Sinibaldi, Saifur Rahman, Chia‐Chien Chiang, Anna M. Hansen, Jill Henault, Carlos P. Roca, Shu Wang, Kamelia Zerrouki, Rebecca Filippi, Christopher Groves, Zerai Manna, Jun Chu, Michael Davis, Sarthak Gupta, Christopher Morehouse, Melissa de los Reyes, Rachel Ettinger, Roland Kolbeck, Mariana J. Kaplan, Miguel A. Sanjuan, Richard M. Siegel, Sarfaraz A. Hasni, Kerry A. Casey   +23 more
wiley   +1 more source

Age‐related differences in hydroxychloroquine‐associated adverse events: A pharmacovigilance study based on the FDA Adverse Event Reporting System

British Journal of Clinical Pharmacology, EarlyView.
Aims This real‐world pharmacovigilance study utilizes FDA Adverse Event Reporting System (FAERS) data (2004–2024) to characterize age‐related disparities in hydroxychloroquine (HCQ)‐associated adverse events (AEs), addressing gaps in age‐stratified risk assessment. Methods Disproportionality analysis (reporting odds ratios, RORs) and parametric Weibull
Guanghan Sun, Jingrong Yang, Lei Wan, Xia Xu, Jing Wang   +4 more
wiley   +1 more source

Treatment of discoid lupus erythematosus scarring alopecia with deucravacitinib: A case report

SAGE Open Medical Case Reports
Discoid lupus erythematosus is a chronic, recurring, autoimmune skin disease causing annular, scarring plaques on the head and neck. Deucravacitinib, a tyrosine kinase 2 inhibitor in the Janus kinase inhibitor family, represents an emerging treatment ...
Katherine Aw, Genevieve Gavigan
doaj   +1 more source

Lupus Panniculitis Presenting as Multiple Discharging Sinuses

Clinical Dermatology Review
Lupus erythematosus profundus (lupus panniculitis) is an uncommon variant of panniculitis, which may present as localized entity or in association with systemic lupus erythematosus or discoid lupus erythematosus.
Kanathur Shilpa, Eswari Loganathan, HN Mohan   +2 more
doaj   +1 more source

Lúpus comedônico: rara apresentação do lúpus eritematoso discoide Comedonic lupus: a rare presentation of discoid lupus erythematosus

Anais Brasileiros de Dermatologia, 2011
Lúpus eritematoso cutâneo crônico é doença autoimune, com apresentações polimorfas que podem, eventualmente, mimetizar outras condições clínicas, causando dificuldade diagnóstica.
Daniela Ferro Farias, Roberta Marinho Falcão Gondim, Isabella Portela Redighieri, Helena Muller, Valéria Petri   +4 more
doaj   +1 more source

Immunotherapy‐Related Cutaneous Toxicities in Melanoma: A Dermoscopic Perspective

JEADV Clinical Practice, EarlyView.
Dermoscopy serves as a valuable tool in the everyday dermatological and oncological practice for melanoma patients, allowing for the prompt identification of immune‐related cutaneous toxicities and guiding clinicians toward appropriate therapeutic decisions.
Grażyna Kamińska‐Winciorek, Iris Zalaudek, Karolina Zarańska, Bożena Cybulska‐Stopa   +3 more
wiley   +1 more source

Clinical recognition and management of alopecia in women of color,

International Journal of Women's Dermatology, 2019
Certain types of alopecia, such as traction alopecia, discoid lupus erythematosus, and central centrifugal cicatricial alopecia, occur more commonly in African-American individuals than in those of other ethnicities.
Jodie Raffi, BA, Raagini Suresh, BS, Oma Agbai, MD, FAAD   +2 more
doaj   +1 more source

In vivo differentiation of scarring alopecia using line‐field confocal optical coherence tomography: a pilot study

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and Objectives: Diagnosing cicatricial alopecia is challenging. Even with histology, a definitive diagnosis cannot always be made. Line‐field confocal optical coherence tomography (LC‐OCT), a non‐invasive imaging method with high resolution used in vivo, has proven helpful in diagnosing scarring alopecia.
Marie‐Christine Nutz, Julia Welzel, Daniela Hartmann, Lars E. French, Maximilian Deußing, Elke C. Sattler   +5 more
wiley   +1 more source