High Expression of CDK1 and NDC80 Predicts Poor Prognosis of Bladder Cancer [PDF]
arXiv, 2021 Background: Bladder cancer is the 10th most common cancer worldwide, and its prevalence is increasing, especially in developing countries. Objective: In the present study, we employed gene expression profiles from the GSE163209 data set in the GEO database to identify potential molecular and genetic markers in BC patients.
arxiv
Single-cell sequencing shows cellular heterogeneity of cutaneous lesions in lupus erythematosus
Nature Communications, 2022 Discoid lupus erythematosus (DLE) and systemic LE (SLE) can present as cutaneous lesions. Here the authors characterise an scRNA dataset of cutaneous lesions from these patients and compare these to healthy controls showing differential immune cell ...
Meiling Zheng +16 more
doaj +1 more source
multi-GPA-Tree: Statistical Approach for Pleiotropy Informed and Functional Annotation Tree Guided Prioritization of GWAS Results [PDF]
arXiv, 2023 Genome-wide association studies (GWAS) have successfully identified over two hundred thousand genotype-trait associations. Yet some challenges remain. First, complex traits are often associated with many single nucleotide polymorphisms (SNPs), most with small or moderate effect sizes, making them difficult to detect. Second, many complex traits share a
arxiv
Low Dose Thalidomide for Treatment of Resistant Discoid Lupus Erythematosus. A Case Report [PDF]
, 2013 Discoid lupus erythematosus (DLE) is a chronic, indolent, disfiguring disease that is characterized by scaly, erythematous, disk-shaped patches and plaques followed by atrophy, scarring and depigmentation.
Campos, S, Lestre, S, Ponte, P
core
A new stochastic differential equation modelling incidence and prevalence with an application to systemic lupus erythematosus in England and Wales, 1995 [PDF]
arXiv, 2012 This article reformulates a common illness-death model in terms of a new system of stochastical differential equations (SDEs). The SDEs are used to estimate epidemiological characteristics and burden of systemic lupus erythematosus in England and Wales in 1995.
arxiv
MIRACLE: Multi-task Learning based Interpretable Regulation of Autoimmune Diseases through Common Latent Epigenetics [PDF]
arXiv, 2023 DNA methylation is a crucial regulator of gene transcription and has been linked to various diseases, including autoimmune diseases and cancers. However, diagnostics based on DNA methylation face challenges due to large feature sets and small sample sizes, resulting in overfitting and suboptimal performance. To address these issues, we propose MIRACLE,
arxiv
Management of Oral Discoid Lupus Erythematosus [PDF]
Background: Systemic diseases have manifestations in the oral cavity with a variety of lesions that have similar types or forms and can be the first manifestations that appear before the manifestations spread to other areas, therefore a thorough initial ...
Ganesha, Raziv
core +2 more sources
Treatment of Discoid Lupus Erythematosus with Upadacitinib: A Case Report
Clinical, Cosmetic and Investigational Dermatology, 2023 Wenting Hu, Si Zhang, Cuihong Lian Department of Dermatology, Shenzhen Second People’s Hospital, Shenzhen, Guangdong, People’s Republic of ChinaCorrespondence: Cuihong Lian, Department of Dermatology, Shenzhen Second People’s Hospital, No.
Hu W, Zhang S, Lian C
doaj
Oman Medical Journal, 2020 Objectives: We sought to determine the prevalence of immune-mediated skin disorders (IMDs), their oral manifestations, and the related comorbidity among Omani patients with IMDs attending the outpatient Department of Dermatology and Dental Clinic at Al ...
Abla Al Ismaili +3 more
doaj +1 more source
Systemic lupus erythematosus in African-American women: Cognitive physiological modules, autoimmune disease, and structured psychosocial stress [PDF]
arXiv, 2003 Examining elevated rates of systemic lupus erythematosus in African-American women from perspectives of immune cognition suggests the disease constitutes an internalized physiological image of external structured psychosocial stress, a 'pathogenic social hierarchy' involving the synergism of racism and gender discrimination in the context of policy ...
arxiv