Results 71 to 80 of about 10,160 (227)

A Guide to Screening for Autoimmune Diseases in Patients With Vulvar Lichen Sclerosus

Australasian Journal of Dermatology, EarlyView.
ABSTRACTBackgroundThe aetiology of vulvar lichen sclerosus (VLS) remains unknown. However, there is evidence that in addition to a genetic predisposition, autoimmunity contributes to the pathogenesis.ObjectivesThe objective of this study was to determine the prevalence of autoimmune disease and positive autoantibody serology in patients with VLS ...
Annabel Guttentag, Marlene Wijaya, Gayle O. Fischer, Angela Lee, Ken Liu, Rebecca Bronwyn Saunderson   +5 more
wiley   +1 more source

Clustering methods and Bayesian inference for the analysis of the evolution of immune disorders [PDF]

arXiv, 2020
Choosing appropriate hyperparameters for unsupervised clustering algorithms in an optimal way depending on the problem under study is a long standing challenge, which we tackle while adapting clustering algorithms for immune disorder diagnoses. We compare the potential ability of unsupervised clustering algorithms to detect disease flares and remission
arxiv  

Plucked hair follicles from patients with chronic discoid lupus erythematosus show a disease-specific molecular signature [PDF]

, 2019
Objective: When faced with clinical symptoms of scarring alopecia—the standard diagnostic pathway involves a scalp biopsy which is an invasive and expensive procedure.
Alase, AA, Berekmeri, A, Botchkareva, NV, Edward, S, Goodfield, MJ, Md Yusof, MY, Pistolic, J, Shalbaf, M, Stacey, M, Vital, EM, Wittmann, M   +10 more
core   +1 more source

Exploring Cancer‐Associated Fibroblasts in OSCC and OPMDs: Microenvironment Insights. Scoping Review

Oral Diseases, EarlyView.
ABSTRACT Introduction The tumor microenvironment (TME) plays a crucial role in oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMDs). Despite progress, the mechanisms behind the TME‐epithelial cell interaction remain unclear.
Samuele Sutera, Olga Anna Furchì, Monica Pentenero   +2 more
wiley   +1 more source

Depressed serum IgM levels in SLE are restricted to defined subgroups [PDF]

, 2017
Natural IgM autoantibodies have been proposed to convey protection from autoimmune pathogenesis. Herein, we investigated the IgM responses in 396 systemic lupus erythematosus (SLE) patients, divided into subgroups based on distinct autoantibody profiles. Depressed IgM levels were more common in SLE than in matched population controls.
arxiv   +1 more source

GPA-Tree: Statistical Approach for Functional-Annotation-Tree-Guided Prioritization of GWAS Results [PDF]

arXiv, 2021
Motivation: In spite of great success of genome-wide association studies (GWAS), multiple challenges still remain. First, complex traits are often associated with many single nucleotide polymorphisms (SNPs), each with small or moderate effect sizes. Second, our understanding of the functional mechanisms through which genetic variants are associated ...
arxiv  

Efalizumab in the Treatment of Discoid Lupus Erythematosus [PDF]

Archives of Dermatology, 2007
Discoid lupus erythematosus is a chronic inflammatory condition in which the pathogenesis and the role of cell-mediated immunity remains unclear. Currently, the most effective treatments for severe disease are thalidomide, methotrexate, and cyclosporin, although the evidence for this is limited.
Naila Usmani, Mark Goodfield
openaire   +2 more sources

Developing classification criteria for discoid lupus erythematosus: an update from the World Congress of Dermatology 2015 meeting

International Journal of Women's Dermatology, 2016
Currently, no standardized classification criteria exist for cutaneous lupus erythematosus. With increased interest in studying cutaneous lupus erythematosus, specifically discoid lupus erythematosus, it is our aim to apply previously adopted methods ...
Scott A. Elman, AB, Filippa Nyberg, MD, Fukumi Furukawa, MD, Mark Goodfield, MD, Minoru Hasegawa, MD, Branka Marinovic, MD, Jacek Szepietowski, MD, Jan Dutz, MD, FRCPC, Victoria P. Werth, MD, Joseph F. Merola, MD, MMSc   +9 more
doaj  

Current treatment strategies: Collagen vascular diseases in children

Indian Journal of Dermatology, 2012
Of the various collagen vascular diseases seen in pediatric age group, discoid lupus erythematosus, systemic lupus erythematosus, neonatal lupus erythematosus, juvenile dermatomyositis and childhood scleroderma are common and of practical importance to ...
Aparna Palit, Arun C Inamadar
doaj   +1 more source

Unusual Presentation of Facial Comedones

Clinical Case Reports, Volume 13, Issue 5, May 2025.
Comedonal lupus is a rare variant of chronic cutaneous lupus erythematosus. Its misleading clinical appearance may delay diagnosis, which relies on histopathology and direct immunofluorescence. Early treatment is essential to prevent scarring. ABSTRACT Not all facial comedonal lesions represent acne, nor are they always benign.
Lamis Elyamani, Nassiba Zerrouki, Nada Zizi   +2 more
wiley   +1 more source