Results 141 to 150 of about 165,244 (251)

Organ‐Resolved Host Proteomic and Post‐Translational Modification Landscapes in a Mouse Model of Talaromyces marneffei Infection

iMetaMed, EarlyView.
We presented an organ‐resolved, multiple PTM remodeling atlas of systemic T. marneffei infection, integrating quantitative proteome, phosphoproteome, ubiquitinome, acetylome, and lactylome data across the liver, lung, and spleen. The atlas delineated organ‐specific PTM signatures and a functional convergence of divergent modification types on immune ...
Wudi Wei, Shiyi Lai, Xiaotao He, Xiaoting Wei, Xiaoting Xie, Weihong Huang, Baili Zhan, Meng Zhang, Zongxiang Yuan, Rongfeng Chen, Jingzhen Lai, Yuyuan Huang, Kang Li, Sanqi An, Li Ye, Hao Liang, Junjun Jiang   +16 more
wiley   +1 more source

Anifrolumab in Refractory Discoid Lupus Erythematosus without Systemic Involvement: A Case Series of Five Patients. [PDF]

Acta Derm Venereol
Marschner J, Schauer F.
europepmc   +1 more source

Reply to “Understanding the Assumptions on Anifrolumab Dose Regimen Selection for a Phase 3 Trial in Lupus Nephritis”

Clinical Pharmacology &Therapeutics, EarlyView.
Joachim Almquist, Yen Lin Chia, Raj Tummala, Lynn Bertagnolli, David Jayne, Weifeng Tang, Catharina Lindholm   +6 more
wiley   +1 more source

Artificial intelligence‐driven bioinformatics: From analytical pipelines to model‐centered biological discovery

iMetaOmics, EarlyView.
AI‐driven bioinformatics is best viewed as an emerging model‐centered discovery framework in which learned representations increasingly support prediction, intervention design, and workflow orchestration, while classical pipelines remain essential for validation and reproducibility.
Songming Chen, Wei Zhang, Luohuan Dai, Zujian Xiong, Sicen Lai, Haitao Xu, Jia Gu, Kang Peng, Nian Jiang, Hongwei Liu, Xuejun Li   +10 more
wiley   +1 more source

Management Considerations for Patients with Hidradenitis Suppurativa and Lupus Spectrum Disease: A Narrative Review. [PDF]

Dermatol Ther (Heidelb)
Chung CS, Kherallah K, Crew AB, Christianakis S, Hsiao JL, Lee KH.   +5 more
europepmc   +1 more source

Systemic Lupus Erythematosus [PDF]

Proceedings of the Royal Society of Medicine, 1967
openaire   +2 more sources

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Metrnβ drives sepsis immunosuppression via macrophage reprogramming: A novel prognostic biomarker and therapeutic target

Interdisciplinary Medicine, EarlyView.
Metrnβ serves as a novel prognostic biomarker for sepsis and that targeted blockade of the Metrnβ‐c‐Kit axis represents a promising therapeutic strategy for sepsis. Abstract Sepsis is a heterogeneous syndrome critically driven by immunosuppression, yet lacking personalized prognostic markers and therapeutic targets. Here, we provide evidence to support
Xiao Li, Ai Chen, Chen Zhang, Meihong Da, Yonghui Liu, Zhi He, Chenyan Yuan, Shuo Ma, Yuming Yao, Dawen Chen, Meiling Zhou, Zhixin Song, Wenjing Lu, Chun‐Kwok Wong, Guoqiu Wu, Xun Gao   +15 more
wiley   +1 more source

Statement of Retraction: Gypenosides regulate autophagy through Sirt1 pathway and the anti-inflammatory mechanism of mitochondrial autophagy in systemic lupus erythematosus. [PDF]

Bioengineered
europepmc   +1 more source

Shared genetic and molecular architecture between neurodevelopmental disorders and type 1 diabetes

Journal of Intelligent Medicine, EarlyView.
Abstract Epidemiological and clinical studies have suggested possible associations between type 1 diabetes (T1D) and neurodevelopmental disorders (NDDs), but these relationships remain inconsistent across disorders and populations. To clarify whether such mixed findings, we investigated the genetic architecture linking T1D with autism spectrum disorder
Jingxuan Zhang, Zhentao Zhou, Lirong Zhu, Wei Liu   +3 more
wiley   +1 more source