Results 51 to 60 of about 390,856 (338)

Aplastic Crisis as Primary Manifestation of Systemic Lupus Erythematosus [PDF]

, 2011
Aplastic crisis is an unusual feature of systemic lupus erythematosus (SLE). We report the case of a 54-year-old woman presenting with both (extravascular) Coombs-positive hemolytic anemia and laboratory findings of bone marrow hyporegeneration with ...
Alger M, Andreas Völkl, Bailey FA, Brooks, Chute JP, Espinoza JL, Feng X, Fuat S. Oduncu, Hinterberger-Fischer M, Hirano N, Hirano N, Mestanza-Peralta M, Michael Bäuerle, Pavithran K, Philipp Baumann, Ralf Schmidmaier, Singh NP, Tagoe C, Takamatsu H, Tan EM, Torok-Storb B, Wolach B, Young NS, Young NS   +23 more
core   +1 more source

Durability of Response to B‐Cell Maturation Antigen‐Directed mRNA Cell Therapy in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We report the 12‐month follow‐up outcomes from a Phase 2 clinical trial (NCT04146051) evaluating Descartes‐08, a BCMA‐directed RNA chimeric antigen receptor T‐cell (rCAR‐T) therapy for refractory generalized myasthenia gravis (MG).
Nizar Chahin, Gregory Sahagian, Marc H. Feinberg, C. Andrew Stewart, Christopher M. Jewell, Metin Kurtoglu, Miloš D. Miljković, Tuan Vu, Tahseen Mozaffar, James F. Howard Jr, the MG‐001 Study Group   +10 more
wiley   +1 more source

Investigating lupus retention in care to inform interventions for disparities reduction: an observational cohort study. [PDF]

, 2020
BACKGROUND:Systemic lupus erythematous (SLE) disproportionately impacts patients of color and socioeconomically disadvantaged patients. Similar disparities in HIV were reduced through a World Health Organization-endorsed Care Continuum strategy targeting
Ahmad, Umber, Bartels, Christie M, Chang, Ian, Ezeh, Nnenna, Garg, Shivani, Kind, Amy, Rosenthal, Ann, Schletzbaum, Maria, Wang, Xing   +8 more
core  

Belimumab : a technological advance for systemic lupus erythematosus patients? Report of a systematic review and meta-analysis [PDF]

, 2013
Objectives: To undertake a systematic review and meta-analysis to investigate clinical effectiveness of belimumab for patients with systemic lupus erythematosus (SLE) and antinuclear and/or anti-double-stranded DNA (dsDNA) autoantibodies.
Clarke, Aileen, Connock, M., Court, Rachel A., Cummins, E., Gordon, Caroline, Grove, Amy L., Hartley, Louise, Kandala, Ngianga-Bakwin, Mohiuddin, Syed, Sutcliffe, P. (Paul)   +9 more
core   +1 more source

Systemic Lupus Erythematosus (SLE) Therapy: The Old and the New

Rheumatology and Therapy, 2020
Despite recent improvements in the treatment of systemic lupus erythematosus (SLE), disease activity, comorbidities and drug toxicity significantly contribute to the risk of progressive irreversible damage accrual and increased mortality in patients with
F. Basta, F. Fasola, K. Triantafyllias, A. Schwarting   +3 more
semanticscholar   +1 more source

Relapsing–Remitting Multiple Sclerosis Is Associated With a Dysbiotic Oral Microbiome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurological impairment. While the gut microbiota's role in MS is extensively studied, the association between the oral microbiota and MS remains underexplored, particularly in North American cohorts.
Sukirth M. Ganesan, Meeta Yadav, Sudeep Ghimire, Peter C. Lehman, Apurva J. Patel, Sydney Woods, Heena Olalde, Jemmie Hoang, Mishelle Paullus, Catherine Cherwin, Christine Gill, Tracey Cho, Ashutosh K. Mangalam   +12 more
wiley   +1 more source

Juvenile Systemic Lupus Erythematosus Presenting with Esophagitis and Severe Oral Mucositis

Case Reports in Rheumatology, 2021
We present a case of a previously healthy adolescent female who developed severe oral mucositis and acute esophagitis as her presenting symptoms of juvenile systemic lupus erythematosus.
Emily Schildt, Kristen L Sessions, Deirdre De Ranieri   +2 more
doaj   +1 more source

Antineutrophil Cytoplasmic Autoantibody-Negative Pauci-Immune Crescentic Glomerulonephritis in a Patient with Systemic Lupus Erythematosus

Case Reports in Nephrology and Dialysis, 2022
Renal involvement in systemic lupus erythematosus is usually exhibited as lupus nephritis, which is a form of immune complex-mediated glomerulonephritis and one of the most severe organ manifestations of systemic lupus erythematosus.
Chee Eng Chan, Tze Jian Ng, Mohd Kamil Ahmad, Fariz Safhan Mohamad Nor   +3 more
doaj   +1 more source

The use of anti-ribosomal P antibodies in the diagnosis of cerebral lupus: superiority of western blotting over enzyme-linnked immunosorbent assay [PDF]

, 1998
This study investigated the use of anti-ribosomal P antibodies in the diagnosis of cerebral complications of systemic lupus erythematosus using two different methodsԸ?western blotting and enzyme-linked immunosorbent assay.
Chan, EYT, Ko, OKH, Lau, WCS, Lawton, JWM   +3 more
core  

The Relationship Between Inflammation and Central Nervous System in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Aim Multiple sclerosis is an autoimmune demyelination disease that is seen especially in the young population and has a progressive course, causing motor, sensory, and cognitive deficits. In the literature, the pathogenesis of MS disease and the interconnection between the immune and central nervous system in the disease have not been fully ...
Gamze Ansen, Ali Behram Salar, Abdulkadir Ermis, Erkingul Birday, Lutfu Hanoglu, Bayram Ufuk Sakul   +5 more
wiley   +1 more source