Results 81 to 90 of about 154,569 (253)

The RNA‐Binding Protein PARN Remodeled 3′ UTR Structure Defines Poly(A)‐Loading Sites to Mediate Immunoglobulin Homeostasis

Advanced Science, EarlyView.
ABSTRACT Class Switch Recombination (CSR) is essential for generating high‐affinity antibody isotypes from IgM during adaptive humoral responses. Despite well‐established roles for various transcription factors, whether CSR is subject to dedicated post‐transcriptional control represents a significant gap in knowledge.
Siyuan Sun, Chen Yang, Xiaoyu Wang, Naijing Hu, Shengyao Zhang, Xinchun Li, Yu Chen, Jianan Zhai, Xiangfeng Tang, Wei Lu, Chenxu Lu, Changchang Cao, Weiru Yu, Wenhao Wu, Xiaonan Nie, Fengchao Wang, Bing Fang, Fazheng Ren, Yixuan Li, Juan Chen   +19 more
wiley   +1 more source

LP-126 The infectious complication in multitarget therapy of class V lupus nephritis: a case report

Lupus Science and Medicine, 2023
Anastasiia Shumilova, Tatiana Popkova, Tatiana Panafidina, Aleksandr Lila   +3 more
doaj   +1 more source

BCMA‐Engineered Dendritic Cell‐Derived Exosomes as Bi‐Functional Therapeutics Orchestrating Cytokine Sequestration and Immune Activation for Multiple Myeloma

Advanced Science, EarlyView.
A dual‐function cell‐free therapeutic based on DC2.4 cell‐derived exosomes engineered to display BCMA. (Left) Soluble Ligand Sequestration (Decoy Function): DB Exo act as molecular decoys that predominantly sequester soluble APRIL with partial BAFF attenuation, effectively disrupting the NF‐κB survival signaling axis and suppressing myeloma cell ...
Yuqing Zeng, Chao He, Zhibin He, Hongbo Chen, Fang Cheng, Yongjiang Zheng   +5 more
wiley   +1 more source

LP-048 Characteristics and clinical outcome of incomplete systemic lupus erythematosus

Lupus Science and Medicine, 2023
Anastasiia Shumilova, Evgeniy Nasonov, Yulia Gorbunova, Tatiana Popkova, Tatiana Panafidina, Liubov Kondrateva, Alexandr Lila   +6 more
doaj   +1 more source

Clinical and serological manifestations associated with interferon-α levels in childhood-onset systemic lupus erythematosus

Clinics, 2012
OBJECTIVE: To determine the serum levels of interferon alpha in childhood-onset systemic lupus erythematosus patients, their first-degree relatives and healthy controls and to evaluate the associations between serum interferon alpha and disease activity,
Mariana Postal, Nailu Angélica Sinicato, Karina Oliveira Peliçari, Roberto Marini, Lilian Tereza Lavras Costallat, Simone Appenzeller   +5 more
doaj  

Bilateral retinal vasculitis presenting as the first manifestation of systemic lupus erythematosus: a case report

Journal of Medical Case Reports
Background Systemic lupus erythematosus is a chronic autoimmune multisystemic disease in which ocular manifestations occur in up to one-third of patients.
Chirath Priyanga Madurapperuma, Thuvarakan Poobalasingam, Melina Dissanayake, Supul Banagala, Sivatharsini Nagarajah, Bhatiya Premaratne, Keembiyage Ranasiri Dayawansa, Monika De Silva, Harindra Karunatilake   +8 more
doaj   +1 more source

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

LP-027 Overweight and obesity phenotypes based on body mass index and insulin resistance in women with systemic lupus erythematosus

Lupus Science and Medicine, 2023
Yulia Gorbunova, Elena Gerasimova, Tatiana Popkova, Tatiana Panafidina, Liubov Kondrateva   +4 more
doaj   +1 more source

Evans syndrome as a presentation in systemic lupus erythematous, coexisting with Hashimoto’s thyroiditis and pernicious anemia: a case report

Journal of Medical Case Reports
Background Evans syndrome is a rare disorder characterized by the simultaneous or sequential combination of autoimmune hemolytic anemia and immunological thrombocytopenia, together with a positive direct antiglobulin test.
Maryam Mansour, Arwa Shamasnah, Deema Alsaadi, Saja Abu Saif, Akram krama   +4 more
doaj   +1 more source

Clinical and Laboratory Characterization of Acquired Von Willebrand Syndrome

American Journal of Hematology, EarlyView.
ABSTRACT Acquired von Willebrand Syndrome (AVWS) is a rare bleeding disorder characterized by quantitative or qualitative defects of von Willebrand factor (VWF) in patients without a personal or family history of bleeding. It is frequently associated with systemic diseases, particularly lymphoproliferative disorders (LPDs) and myeloproliferative ...
Alessandro Ciavarella, Luciano Baronciani, Omid Seidizadeh, Paola Colpani, Elio Ingenito, Daniele Cattaneo, Maria Teresa Pagliari, Addolorata Truma, Alessandra Iurlo, Simona Maria Siboni, Flora Peyvandi   +10 more
wiley   +1 more source