Results 91 to 100 of about 1,279,892 (312)

Macrophage RSAD2 Couples mtDNA Synthesis With a Self‐Amplifying Inflammatory Circuit to Orchestrate Tissue Repair

Advanced Science, EarlyView.
Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan, Shukui Du, Chunfei Li, Xinjie Li, Shuyang Mu, Anran Qu, Hengxu Yan, Chongchong Xu, Jinnong Yang, Jingkai Sun, Yijun Wang, Jiayang Xiao, Fuyuan Zhang, Linlin Wang, Tiegang Li, Rui Zhao, Dawei Guan   +16 more
wiley   +1 more source

Clinical correlates and outcomes in a group of Puerto Ricans with systemic lupus erythematosus hospitalized due to severe infections

SAGE Open Medicine, 2018
Objective: Infections are a major cause of morbidity and mortality in systemic lupus erythematosus. Clinical outcomes of systemic lupus erythematosus patients hospitalized due to infections vary among different ethnic populations. Thus, we determined the
Patricia Jordán-González, Lee Ming Shum, Lorena González-Sepúlveda, Luis M Vilá   +3 more
doaj   +1 more source

The lupus band test in systemic lupus erythematosus patients

, 2011
Adam Reich, Katarzyna Marcinow, Rafal Bialynicki-BirulaDepartment of Dermatology, Venereology, and Allergology, Wroclaw Medical University, Wroclaw, PolandAbstract: The lupus band test (LBT) is a diagnostic procedure that is used to detect deposits of ...
Adam Reich, Rafal Bialynicki-Birula, Katarzyna Marcinow   +2 more
core   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Acute pancreatitis as an initial presentation of systemic lupus erythematosus: a case report

Journal of Medical Case Reports
Background Systemic lupus erythematosus is a systemic autoimmune disease affecting different organ systems. Gastrointestinal symptoms in patients with systemic lupus erythematosus are common. But systemic lupus erythematosus-related acute pancreatitis is
Mengyu Li, Sutong Li
doaj   +1 more source

Patients with systemic lupus erythematosus have higher prevalence of thyroid autoantibodies: a systematic review and meta-analysis.

PLoS ONE, 2015
BackgroundThyroid autoimmunity is considered the most common type of organ-specific autoimmune disorder and can be associated with other autoimmune endocrine disorders or non-endocrine diseases.
Xi-Feng Pan, Jian-Qiu Gu, Zhong-Yan Shan
doaj   +1 more source

Alcohol, smoking and illicit drug use in pediatric systemic lupus erythematosus patients

Revista Brasileira de Reumatologia, 2016
Objective To evaluate alcohol, smoking and/or illicit drug use, and history of bullying in adolescent childhood-onset systemic lupus erythematosus and healthy controls. Methods 174 adolescents with pediatric rheumatic diseases were selected.
Marlon van Weelden, Lígia B. Queiroz, Daniela M.R. Lourenço, Katia Kozu, Benito Lourenço, Clovis A. Silva   +5 more
doaj   +1 more source

Revisiting Childhood-Onset Systemic Lupus Erythematosus

Childhood-onset systemic lupus erythematosus (cSLE) is a chronic autoimmune disease with a multisystemic involvement diagnosed during childhood. The disease is marked by the production of autoantibodies targeting self-antigens, often before symptoms ...
Pınar Özge Avar-Aydın, Hermine I. Brunner   +1 more
core   +1 more source

Prevalence of neuropsychiatric systemic lupus erythematosus (NPSLE) in patients with systemic lupus erythematosus (SLE).

, 2015
Prevalence of neuropsychiatric systemic lupus erythematosus (NPSLE) in patients with systemic lupus erythematosus (SLE).
Tomasz Hawro (703398), Maria Krupińska-Kun (703400), Anna Woźniacka (703401), Marcus Maurer (224879), Andrzej Bogucki (703399)   +4 more
core   +1 more source

Extracellular Vesicle Packaged TDP43 Derived From ECs Exacerbates Cigarette Tar‐Related Atherosclerosis Progression via Enhancing Macrophage Extracellular Traps

Advanced Science, EarlyView.
Cigarette tar triggers EC‐derived EVs carrying TDP43, which binds VDAC1 to boost MAMs, mitochondrial Ca2+ overload, and METs formation in macrophages, accelerating smoking‐related AS progression, while retinoic acid binds TDP43 to block this pathogenic cascade.
Xinxin Zhu, Yuwu Chen, Wei Meng, Biyi Xu, Junke Mou, Xiaolin Liu, Mengyang Wang, Qishuo Gu, Qianhui Sun, Man Li, Chen Zhao, Ming Zeng, Ying Lv, Boling Yi, Sheng Qu, Xiaoxuan Bai, Ji Li, Xing Luo, Sining Hu, Bo Yu, Haibo Jia   +20 more
wiley   +1 more source