Results 101 to 110 of about 371,009 (363)

Alopecias in lupus erythematosus [PDF]

Lupus Science & Medicine, 2018
Several patterns of hair loss can occur in lupus erythematosus (LE). Alopecias which show histological characteristics of LE are LE-specific, and include discoid LE (DLE), diffuse or patchy hair loss in acute LE, subacute cutaneous LE, and rarely tumid LE.
Josef Symon S. Concha, Victoria P. Werth
openaire   +2 more sources

Acute pancreatitis as an initial presentation of systemic lupus erythematosus: a case report. [PDF]

J Med Case Rep
Background Systemic lupus erythematosus is a systemic autoimmune disease affecting different organ systems. Gastrointestinal symptoms in patients with systemic lupus erythematosus are common. But systemic lupus erythematosus-related acute pancreatitis is
Li M, Li S.
europepmc   +2 more sources

Systemic lupus erythematosus [PDF]

Postgraduate Medical Journal, 1988
Summary Systemic lupus erythematosus is a common disease--studies throughout the world broadly agree on a prevalence of 1 in 1000 women. Recently an important clinical advance has come from the description of a syndrome of recurrent thrombosis, recurrent abortion and neurological disease associated with antiphospholipid antibodies.
openaire   +4 more sources

Disease course patterns in systemic lupus erythematosus

Lupus, 2018
Background Disease activity in systemic lupus erythematosus follows three different courses: long quiescent, relapsing remitting and persistently active. However, the patterns of disease course since diagnosis are not known.
K. Tselios, D. Gladman, Z. Touma, J. Su, N. Anderson, M. Urowitz   +5 more
semanticscholar   +1 more source

Psychoses of Epilepsy: Unravelling the Phenotypic and Genotypic Features

Annals of Neurology, EarlyView.
Objectives We analyzed the genotypic and phenotypic features of patients with psychosis of epilepsy (POE). Methods Patients with POE recruited to an epilepsy genetics research program underwent phenotyping and genetic analysis. The latter included screening for rare pathogenic variants in epilepsy genes, and polygenic risk score (PRS) calculation for ...
Genevieve Rayner, Eliza Honybun, Melanie Bahlo, Karen L. Oliver, Ingrid E. Scheffer   +4 more
wiley   +1 more source

COMO: A Pipeline for Multi-Omics Data Integration in Metabolic Modeling and Drug Discovery [PDF]

arXiv, 2020
Identifying potential drug targets using metabolic modeling requires integrating multiple modeling methods and heterogenous biological datasets, which can be challenging without sophisticated tools. We developed COMO, a user-friendly pipeline that integrates multi-omics data processing, context-specific metabolic model development, simulations, drug ...
arxiv  

Systemic Lupus Erythematosus [PDF]

BMJ, 1957
Lupus is a serious, potentially life-threatening disease. Its natural history is to culminate in a crescendo of autoimmunity and organ involvement. Difficulty arriving at the diagnosis may delay institution of therapy, which although helpful brings new problems. The fundamental understanding of this disease has made major strides. There is no consensus
openaire   +6 more sources

Outcome of Patients With Lupus Nephritis Treated With an Anti‐CD40 Monoclonal Antibody According to Kidney Biopsy Features

Arthritis &Rheumatology, EarlyView.
Objective A phase 2 trial tested different doses of the anti‐CD40 monoclonal antibody BI 655064 as an add‐on therapy to the standard of care in patients with class III or IV lupus nephritis (LN) with active disease. A post hoc analysis showed a potential benefit of the higher tested doses (180 and 240 mg) versus a low dose (120 mg) or placebo.
Martina Uzzo, Helmut Schumacher, Juergen Steffgen, Simone Deutschel, David Jayne, Ingeborg Bajema   +5 more
wiley   +1 more source

Obliterative portal venopathy: A neglected and probably misdiagnosed disease with peculiar etiology in South America

JGH Open, Volume 6, Issue 12, Page 904-909, December 2022., 2022
Classically described in the group of non‐cirrhotic portal hypertension, obliterative portal venopathy (OPV) causes are still unknown. Our aim is to describe the characteristics of 43 OPV patients and potential risk factors. Clinically significant portal hypertension was found in 28% of cases. The most frequent indication for liver biopsy was elevation
Vinícius Nunes, Luiz A R de Freitas, Juliana R de Freitas, Caio Araújo, Gildásio N Junior, Maria I Schinoni, Fernando Bessone, Raymundo Paraná   +7 more
wiley   +1 more source

Topical Mupirocin Treatment Reduces Interferon and Myeloid Signatures in Cutaneous Lupus Erythematous Lesions Through Targeting of Staphylococcus Species

Arthritis &Rheumatology, EarlyView.
Objective Cutaneous lupus erythematosus (CLE) is an inflammatory skin manifestation of systemic lupus erythematosus. Type I interferons (IFNs) promote inflammatory responses and are elevated in CLE lesions. We recently reported that CLE lesions are frequently colonized with Staphylococcus aureus.
Lisa Abernathy‐Close, Joseph Mears, Allison C. Billi, Sirisha Sirobhushanam, Celine Berthier, Annie Lu, Zeran Zhang, Amy Hurst, Johann E. Gudjonsson, J. Michelle Kahlenberg   +9 more
wiley   +1 more source