Results 131 to 140 of about 371,009 (363)

Transancestral mapping and genetic load in systemic lupus erythematosus

Nature Communications, 2017
Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals of European (EA), African (AA) and ...
C. Langefeld, H. Ainsworth, D. C. Graham, J. Kelly, M. Comeau, M. Marion, T. Howard, Paula S. Ramos, Jennifer A. Croker, D. Morris, J. Sandling, J. Almlöf, E. Acevedo-Vásquez, G. Alarcón, A. Babini, V. Baca, A. Bengtsson, G. Berbotto, M. Bijl, E. Brown, H. Brunner, M. Cardiel, L. Catoggio, R. Cervera, J. Cucho-Venegas, S. R. Dahlqvist, S. D'alfonso, B. M. da Silva, Iñigo de la Rúa Figueroa, A. Doria, J. Edberg, E. Endreffy, J. Esquivel-Valerio, P. Fortin, B. Freedman, J. Frostegård, Mercedes A. García, I. G. De La Torre, G. Gilkeson, D. Gladman, I. Gunnarsson, J. Guthridge, J. Huggins, J. James, C. Kallenberg, D. Kamen, D. Karp, K. Kaufman, Leah C. Kottyan, L. Kovács, H. Laustrup, B. Lauwerys, Quanzhen Li, M. Maradiaga-Ceceña, Javier Martín, Joseph Mccune, David R. McWilliams, J. Merrill, P. Miranda, J. F. Moctezuma, S. Nath, T. Niewold, L. Orozco, N. Ortego-Centeno, M. Petri, C. Pineau, B. Pons-Estel, J. Pope, P. Raj, R. Ramsey‐Goldman, J. Reveille, Laurie P. Russell, J. Sabio, C. Aguilar-Salinas, H. Scherbarth, R. Scorza, M. Seldin, C. Sjöwall, E. Svenungsson, S. Thompson, S. Toloza, L. Truedsson, Teresa Tusié-Luna, C. Vasconcelos, L. Vilá, D. Wallace, M. Weisman, J. Wither, T. Bhangale, J. Oksenberg, J. Rioux, P. Gregersen, A. Syvänen, L. Rönnblom, L. Criswell, C. Jacob, K. Sivils, B. Tsao, L. Schanberg, T. Behrens, E. Silverman, M. Alarcón-Riquelme, R. Kimberly, J. Harley, E. Wakeland, R. Graham, P. Gaffney, T. Vyse   +107 more
semanticscholar   +1 more source

Associação entre lúpus eritematoso e tabagismo Association between lupus erythematosus and smoking

Anais Brasileiros de Dermatologia, 2008
FUNDAMENTOS: O lúpus eritematoso é doença crônica, auto-imune, que reúne manifestações exclusivamente cutâneas ou multissistêmicas, caracterizada pela produção de auto-anticorpos contra vários constituintes celulares.
Júnia Maria Fernandes Araújo, Ana Rosa Magaldi Ribeiro de Oliveira, Sâmya Diégues Cedrim, Olímpia Castelo Tristão, Aloísio Gamonal   +4 more
doaj   +1 more source

Aberrant glycosylation of IgG in children with active lupus nephritis alters podocyte metabolism and causes podocyte injury

Arthritis &Rheumatology, Accepted Article.
Background Podocytes are integral to the maintenance of the glomerular filtration barrier. Their injury results in proteinuria and disease progression in lupus nephritis (LN). Aberrant IgG glycosylation drives podocyte injury in LN and leads to cytoskeletal rearrangement, motility changes and decreased nephrin production.
Rhea Bhargava, Rohit Upadhyay, Cong Zhao, Prasad Katakam, Scott Wenderfer, Jing Chen, Hua He, Richard Cummings, Maria G. Tsokos, George C. Tsokos   +9 more
wiley   +1 more source

Plasma cytokines as potential biomarkers of kidney damage in patients with systemic lupus erythematosus

Lupus, 2018
Background Systemic lupus erythematosus is a heterogeneous chronic inflammatory autoimmune disorder characterized by an exacerbated expression of cytokines and chemokines in different tissues and organs.
L. Pacheco-Lugo, J. Sáenz-García, E. Navarro Quiroz, H. G. González Torres, L. Fang, Y. Díaz-Olmos, G. Garavito De Egea, E. Egea Bermejo, Gustavo Aroca-Martínez   +8 more
semanticscholar   +1 more source

Recurrent podocytopathy in a patient with systemic lupus erythematosus

SAGE Open Medical Case Reports, 2017
Podocytopathy in systemic lupus erythematosus is characterised by diffuse foot process effacement without significant peripheral capillary wall immune deposits as seen on electron microscopy.
Shereen Paramalingam, Daniel D Wong, Gursharan K Dogra, Johannes C Nossent   +3 more
doaj   +1 more source

Effect of long‐term voclosporin treatment on renal histology in patients with active lupus nephritis with repeat renal biopsies

Arthritis &Rheumatology, Accepted Article.
Objective This study characterized the impact of voclosporin on kidney histology in patients with lupus nephritis (LN) who had protocolized repeat kidney biopsies in the AURORA clinical trials. Methods Patients were randomized to voclosporin or placebo treatment for up to three years; all patients received mycophenolate mofetil and low‐dose ...
Brad H. Rovin, Clarissa Cassol, Samir V. Parikh, Amit Saxena, Neil Solomons, Vanessa Birardi, Ernie Yap, Clint W. Abner, David R.W. Jayne, Robert B. Huizinga   +9 more
wiley   +1 more source

Employing latent variable models to improve efficiency in composite endpoint analysis [PDF]

arXiv, 2019
Composite endpoints that combine multiple outcomes on different scales are common in clinical trials, particularly in chronic conditions. In many of these cases, patients will have to cross a predefined responder threshold in each of the outcomes to be classed as a responder overall.
arxiv  

Narrative of an Instance of Cure of Lupus Erythematosus [PDF]

, 1885
Joseph William Hutchinson
openalex   +1 more source

THE TREATMENT OF LUPUS ERYTHEMATOSUS. [PDF]

, 1909
Malcolm Morris
openalex   +1 more source

Moulage: "Lupus Erythematosus"

Dermatology Practical & Conceptual, 2011
The first description of lupus erythematosus was given by Pierre Louis Alphee Cazenave, who was a coworker of Laurent-Theodore Biett, in 1851. He used the French term “lupus erythemateux.” In 1856 Ferdinand Hebra translated this work into German and coined the term lupus erythematosus, which is the Latin translation, and in 1863 Isidor Neumann ...
openaire   +3 more sources