Results 21 to 30 of about 411,697 (349)

2019 update of the EULAR recommendations for the management of systemic lupus erythematosus

Annals of the Rheumatic Diseases, 2019
Our objective was to update the EULAR recommendations for the management of systemic lupus erythematosus (SLE), based on emerging new evidence. We performed a systematic literature review (01/2007–12/2017), followed by modified Delphi method, to form ...
A. Fanouriakis, M. Kostopoulou, A. Alunno, M. Aringer, I. Bajema, J. Boletis, R. Cervera, A. Doria, C. Gordon, M. Govoni, F. Houssiau, D. Jayne, M. Kouloumas, A. Kuhn, J. Larsen, K. Lerstrøm, G. Moroni, M. Mosca, Matthias Schneider, J. Smolen, E. Svenungsson, V. Tesar, A. Tincani, A. Troldborg, R. V. van Vollenhoven, J. Wenzel, G. Bertsias, D. Boumpas   +27 more
semanticscholar   +1 more source

Systemic lupus erythematosus-myositis overlap syndrome with lupus nephritis

Journal of Family Medicine and Primary Care, 2020
Systemic lupus erythematosus-myositis overlap syndrome is rare with prognostic implications. Reports suggest that systemic lupus erythematosus-myositis overlap syndrome with lupus nephritis has a variable clinical outcome.
Biswajit Dey, Vandana Rapahel, Yookarin Khonglah, Md Jamil   +3 more
doaj   +1 more source

Mapping Systemic Lupus Erythematosus heterogeneity at the single-cell level

Nature Immunology, 2020
Patients with systemic lupus erythematosus (SLE) display a complex blood transcriptome whose cellular origin is poorly resolved. Using single-cell RNA sequencing, we profiled ~276,000 peripheral blood mononuclear cells from 33 children with SLE with ...
Djamel Nehar-Belaid, Seunghee Hong, R. Marches, Guo Chen, M. Bolisetty, Jeanine Baisch, Lynnette Walters, M. Punaro, R. Rossi, C. Chung, Richie Huynh, Prashant Singh, W. Flynn, Joy-Ann Tabanor-Gayle, N. Kuchipudi, A. Mejías, Magalie A. Collet, Anna Lisa Lucido, K. Palucka, P. Robson, S. Lakshminarayanan, O. Ramilo, Tracey Wright, V. Pascual, J. Banchereau   +24 more
semanticscholar   +1 more source

Targeting CD38 with Daratumumab in Refractory Systemic Lupus Erythematosus.

New England Journal of Medicine, 2020
Daratumumab, a human monoclonal antibody that targets CD38, depletes plasma cells and is approved for the treatment of multiple myeloma. Long-lived plasma cells are implicated in the pathogenesis of systemic lupus erythematosus because they secrete ...
L. Ostendorf, M. Burns, P. Durek, G. Heinz, F. Heinrich, P. Garantziotis, P. Enghard, U. Richter, R. Biesen, U. Schneider, F. Knebel, G. Burmester, Andreas Radbruch, H. Mei, M. Mashreghi, F. Hiepe, T. Alexander   +16 more
semanticscholar   +1 more source

Systemic lupus erythematosus with subacute cutaneous manifestation – acute on chronic.

Galicia Clínica, 2018
Systemic Lupus Erythematosus (SLE) presents as a continuum, with some patients demonstrating only cutaneous manifestations, such as Chronic Cutaneous Lupus Erythematosus (CCLE) or other more severe organ manifestations as in SLE.
Juliana Lopes, Isabel Almeida
doaj   +1 more source

Toll-like receptor signalling in B cells during systemic lupus erythematosus

Nature Reviews Rheumatology, 2020
B lymphocytes have a central role in autoimmune diseases, which are often defined by specific autoantibody patterns and feature a loss of B cell tolerance.
S. Fillatreau, B. Manfroi, T. Dörner
semanticscholar   +1 more source

Achados capilaroscópicos no lúpus eritematoso Capillaroscopy findings in lupus erythematosus

Anais Brasileiros de Dermatologia, 2006
FUNDAMENTOS: A capilaroscopia é método não invasivo e reprodutível capaz de analisar diretamente os capilares na região periungueal, auxiliando no diagnóstico diferencial das doenças do tecido conectivo.
Anamaria da Silva Facina, Mario Luiz Cardoso Pucinelli, Mônica Ribeiro Azevedo Vasconcellos, Luci Biaggi Ferraz, Fernando Augusto de Almeida   +4 more
doaj   +1 more source

Diagnosis of tuberculosis with autoimmune hepatitis–systemic lupus erythematosus overlap syndrome: a case report

Journal of Medical Case Reports, 2022
Background There is ample evidence indicating that immunosuppressive therapy or immune dysregulation in systemic lupus erythematosus increases the risk for tuberculosis.
Shekhar, Nikita Yogesh Gupta, Avi Ravi Harisingani   +2 more
doaj   +1 more source

Systemic Lupus Erythematosus (SLE) Therapy: The Old and the New

Rheumatology and Therapy, 2020
Despite recent improvements in the treatment of systemic lupus erythematosus (SLE), disease activity, comorbidities and drug toxicity significantly contribute to the risk of progressive irreversible damage accrual and increased mortality in patients with
F. Basta, F. Fasola, K. Triantafyllias, A. Schwarting   +3 more
semanticscholar   +1 more source

Systemic lupus erythematosus [PDF]

Orphanet Journal of Rare Diseases, 2006
Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease, which is autoimmune in origin and is characterized by the presence of autoantibodies directed against nuclear antigens. It is a multi-system disease, and patients can present in vastly different ways.
Anisur Rahman, Jessica J Manson
openaire   +6 more sources