Results 141 to 150 of about 65,459 (255)

Representation, medical examination, and the effectiveness of underwriting: Evidence from a life and health insurance company

Risk Management and Insurance Review, EarlyView.
Abstract This study examines whether underwriting methods—representation, medical examination, extra premiums, and coverage—effectively mitigate adverse selection using data from an insurance company. Regarding representation, we focus on statements disclosing pre‐existing medical conditions.
Chia‐Ling Ho, Gene Lai, Chen‐Hsu Liao, Zifen Zeng   +3 more
wiley   +1 more source

IgA Nephropathy in a Patient with Systemic Lupus Erythematosus

Turkish Journal of Nephrology, 2019
Systemic lupus erythematosus (SLE) is an autoimmune disorder. One of the most typical aspects of SLE is renal involvement. Lupus nephritis is a serious disease whose prognosis can usually be improved dramatically by treatment.
Süleyman KARAKÖSE, Selman ÜNVERDİ, Eyüp KOÇ, Arzu ENSARİ, Murat DURANAY   +4 more
doaj  

Expression characteristics of dual‐specificity phosphatase 2 and hypoxia‐inducible factor‐1α in acute kidney injury and preliminary study of the effect of dual‐specificity phosphatase 2 on HK‐2 cells

Experimental Physiology, EarlyView.
ABSTRACT Acute kidney injury (AKI) is a global health problem with significant long‐term harm if the prognosis is poor. Dual‐specificity phosphatase 2 (DUSP2) is involved in key regulatory pathways in several disease processes, but its function in renal pathophysiology is unclear.
Xueqian Chu, Songmin Xue, Lanyan Lin, Xuan Huang, Sisi Chen, Wulaer Adeli, Zulibiya Tuohetiyaer, Suhua Li, Chen Lu   +8 more
wiley   +1 more source

Hypertension and its complications in a young man with autoimmune disease [PDF]

, 2017
Basile, Jan N., Batlle, Daniel C., Dhaun, Neeraj, Dominiczak, Anna F., Elijovich, Fernando, Jennings, Garry L.R., Laffer, Cheryl L., Miller-Hodges, Eve, Oliveras, Anna, Oparil, Suzanne   +9 more
core   +1 more source

The ERβ Agonist, OSU‐ERβ‐012, Mitigates Inflammation in a Chimeric Model of Systemic Lupus Erythematosus

ACR Open Rheumatology, Volume 8, Issue 5, May 2026.
Objective Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple organ damage, affecting women between the ages of 15 and 45 years at a 9:1 rate as compared to men. The etiology of SLE is complex and elusive; however, the susceptibility of women during the years in which estrogen levels are at their highest suggests a ...
Braden Zeno, Shane Bruckner, Hongyu Yuan, Morgan Stahl, Timothy Alexandrov, Kyle Jablonski, Judith Lin, Nicholas A. Young, Wael N. Jarjour   +8 more
wiley   +1 more source

Lupus, a Leading Cause of Years of Potential Life Lost in Young Women: Implications for Public Health Priorities and Research Funding

ACR Open Rheumatology, Volume 8, Issue 5, May 2026.
Objective Premature mortality burden is an important component of disease burden and can help guide health care and research priorities. However, relying solely on mortality rates may underestimate lupus mortality burden because a substantial proportion of deaths occur at younger ages. Years of potential life lost (YPLL) captures premature mortality by
Eric Y. Yen, Elizabeth J. Park, Ram Raj Singh   +2 more
wiley   +1 more source

Integrative Analyses Identify a cGAS‐STING Pathway‐Driven Signature With Context‐Dependent Roles in Systemic Lupus Erythematosus

Advanced Science, Volume 13, Issue 25, 4 May 2026.
Zhang et al. identify M7core, a critical cGAS‐STING pathway‐driven gene signature that is activated in most lupus patients’ blood and links to lupus disease severity, lymphopenia, and lupus nephritis. They further reveal the diagnostic and pathogenic characteristics of M7core and emphasize the importance of assessing pathway activity before initiating ...
Lele Zhang, Ming‐Ju Amy Lyu, Ze Hong, Jing Sun, Lan Guo, Jiameng Hu, Munire Maimaiti, Chenhui Li, Jinyi Song, Xiang Zhang, Huansha Yu, Chen Wang, Xuan Wang, Haiyang Hu   +13 more
wiley   +1 more source

Noonan Syndrome Spectrum Disorders Predispose to Systemic Lupus Erythematosus: Case Report and Critical Review of the Literature

American Journal of Medical Genetics Part A, Volume 200, Issue 5, Page 1091-1097, May 2026.
ABSTRACT RASopathies are clinically overlapping neurodevelopmental syndromes resulting from germline mutations in genes involved in the rat sarcoma/mitogen‐activated protein kinases (RAS/MAPK) pathway. Historically, RASopathies have been described by clinical phenotypes, such as Noonan syndrome and Neurofibromatosis type I.
Anastasia‐Vasiliki Madenidou, Gillian I. Rice, James O'Sullivan, Ben Parker, Ian N. Bruce, Emma Burkitt‐Wright, Tracy A. Briggs   +6 more
wiley   +1 more source

The Current Use and Future Perspectives of Biosimilars in Pediatric Healthcare: A Narrative Review

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims The integration of biosimilars into pediatric healthcare represents a significant evolution in treatment accessibility and cost‐effectiveness. Biosimilars—biological products highly similar to already approved biologics, have emerged as promising alternatives for managing chronic and rare pediatric conditions, including ...
Zubaier Ahmed, Tasfiah Tasnim Maha, Sanjana Nowsher, Wasima Taslim, Fatema‐Tuz‐Zohora, Sabrina Sharmin, Hasina Yasmin   +6 more
wiley   +1 more source

Carbohydrate‐Based Drug Discovery: Synthetic Strategies and Clinical Applications

Israel Journal of Chemistry, Volume 66, Issue 3, May 2026.
The picture depicts the molecules discussed in the review. On the left side, the general scaffold of sugars is shown. Next to it are four carbohydrate‐based molecules, including remdesivir, islatravir, empagliflozin, and Globo‐H. Remdesivir and islatravir contain a substituted ribose ring attached to a modified nucleobase.
Stephan Scheeff, Jemma Arakelyan, Billy Wai‐Lung Ng   +2 more
wiley   +1 more source