Results 71 to 80 of about 268,948 (265)

Kidney Tissue Hypoxia Dictates T-Cell Mediated Injury in Murine Lupus Nephritis

Science Translational Medicine, 2020
HIF-1 dictates effector function of infiltrating T cells in lupus, causing tissue damage that can be abrogated by its blockade in murine models. Hypoxic autoimmunity Systemic lupus erythematosus causes severe damage in multiple organs, including the ...
Ping-Min Chen, Parker C. Wilson, Justin A Shyer, M. Veselits, H. Steach, Can Cui, G. Moeckel, M. Clark, J. Craft   +8 more
semanticscholar   +1 more source

The treatment of lupus nephritis [PDF]

BMJ, 2005
New and more conservative approaches in treatment are a major advance F or 30 years the US National Institutes of Health have dominated the treatment of lupus nephritis with controlled trials of monthly high dose intravenous pulse cyclophosphamide, now the standard treatment for nephritis and severe lupus.
David P, D'Cruz, Graham R V, Hughes
openaire   +2 more sources

Clinical, Histologic, and Serological Predictors of Renal Function Loss in Lupus Nephritis

Arthritis Care &Research, EarlyView.
Objective Kidney survival is the ultimate goal in lupus nephritis (LN) management, but long‐term predictors remain inadequately studied, requiring long‐term follow‐up. This study aimed to identify baseline and early longitudinal predictors of kidney survival in the Accelerating Medicines Partnership LN longitudinal cohort.
Shangzhu Zhang, Laurence Magder, Daniel Goldman, Judith A. James, Joel M. Guthridge, Carla Guthridge, Peter Izmirly, Jill P. Buyon, H. Michael Belmont, Richard A. Furie, Noa Schwartz, Chaim Putterman, Jennifer L. Barnas, Jennifer H. Anolik, Sarah French, Maria Dall'Era, Avi Z. Rosenberg, Jeffrey Hodgin, Dawit S. Demeke, the Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (RA/SLE) Network, Michelle Petri, Andrea Fava   +21 more
wiley   +1 more source

High Humidity Exacerbates Psoriasiform Skin Disease Relapse by Increasing Tissue‐Resident Memory T Cells via Altering Skin Microbiota

Advanced Science, EarlyView.
We demonstrated that high humidity worsened psoriasis relapse in murine psoriasiform skin inflammation by increasing skin‐resident memory CD8+ cells via upregulating IL‐15Rα on keratinocytes. The increases in IL‐15Rα and memory CD8+ cells were attributed to S. nepalensis and its metabolite ADMA in skin exposed to high humidity.
Chun‐Ling Liang, Yuchao Chen, Chuanjian Lu, Huazhen Liu, Fenglian Qin, Sisi Dai, Feifei Qiu, Haiming Chen, Weihui Lu, Jonathan S. Bromberg, Zhenhua Dai   +10 more
wiley   +1 more source

Lupus nephritis progression in FcγRIIB-/-yaa mice is associated with early development of glomerular electron dense deposits and loss of renal DNase I in severe disease. [PDF]

PLoS ONE, 2017
FcγRIIB-/-yaa mice develop severe lupus glomerulonephritis due to lack of an inhibitory immune cell receptor combined with a Y-chromosome linked autoimmune accelerator mutation.
Kjersti Daae Horvei, Hege Lynum Pedersen, Silje Fismen, Dhivya Thiyagarajan, Andrea Schneider, Ole Petter Rekvig, Thomas H Winkler, Natalya Seredkina   +7 more
doaj   +1 more source

Tubular Cell and Keratinocyte Single-cell Transcriptomics Applied to Lupus Nephritis Reveal Type I IFN and Fibrosis Relevant Pathways

Nature Immunology, 2019
The molecular and cellular processes that lead to renal damage and to the heterogeneity of lupus nephritis (LN) are not well understood. We applied single-cell RNA sequencing (scRNA-seq) to renal biopsies from patients with LN and evaluated skin biopsies
E. Der, H. Suryawanshi, Pavel Morozov, Manjunath Kustagi, B. Goilav, Saritha Ranabathou, P. Izmirly, R. Clancy, H. Belmont, M. Koenigsberg, M. Mokrzycki, Helen Rominieki, J. Graham, J. Rocca, Nicole Bornkamp, N. Jordan, Emma Schulte, Ming Wu, J. Pullman, Kamil Slowikowski, S. Raychaudhuri, J. Guthridge, J. James, J. Buyon, T. Tuschl, C. Putterman   +25 more
semanticscholar   +1 more source

Update on Lupus Nephritis: Looking for a New Vision

Nephron, 2020
Lupus nephritis (LN) is one of the most common manifestations of systemic lupus erythematosus (SLE), affecting approximately 40% of patients with lupus.
E. Morales, M. Galindo, Hernando Trujillo, M. Praga   +3 more
semanticscholar   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

IgA Nephropathy: A Rare Lesion in Renal Biopsy in Systemic Lupus Erythematosus: Case Reports and Review of Literature

Turkish Journal of Nephrology, 2019
Lupus nephritis is an infl ammation of the kidney caused by systemic lupus erythematosus (SLE). Lupus nephritis is a frequent complication of SLE that increases mortality and morbidity.
Gürsel YILDIZ, Emre ÇİÇEKLİ, Mansur KAYATAŞ, Abdulkerim YILMAZ, Ferhan CANDAN   +4 more
doaj  

The Spectrum of Biopsy‐Proven Renal Diseases in Chinese Elderly Patients and Its Temporal Shift Over 20 Years: A Retrospective Cohort Study

AGING MEDICINE, EarlyView.
This 20‐year retrospective study reveals a significant increase in renal biopsy utilization and a pivotal shift in biopsy‐proven renal disease among Chinese elderly patients. Secondary glomerular nephropathy (particularly diabetic nephropathy and hypertensive nephropathy) has surpassed primary glomerular nephropathy as the leading biopsy‐proven ...
Shasha Han, Lengnan Xu, Ying Sun, Fang Fang, Xin Liu   +4 more
wiley   +1 more source