Results 91 to 100 of about 106,151 (254)

A BASE BIOLÓGICA DA ATENÇÃO

Arquivos de Ciências da Saúde da UNIPAR, 2010
As bases biológicas da função psíquica atenção despertam o interesse de muitos estudiosos. O neuropsicólogo Alexandre Luria é um dos pioneiros a descrever tal processo.
Larissa Aparecida Gonçalves, Silvana Regina de Melo   +1 more
doaj  

The Pavlovian interpretation of speech and aphasia: Alexander Luria and Wilder Penfield

Frontiers in Psychology
This paper discusses a neglected aspect of the historiography of aphasia, the role that Pavlovian conditioning played in Alexander Luria’s and Wilder Penfield’s understanding of the acquisition, expression, and loss of spoken and written speech.
Richard Leblanc
doaj   +1 more source

Thermosensitive Nanostructured Coacervates Developed by Mixing ABA‐ and AB‐Block Copolymers and Their Unique Sustained Release of Nano‐Micelles in a Regulated Manner

Small, EarlyView.
Polyion complex micelles composed of blends of ABA and AB block copolymers can form coacervates with a hexagonally packed cylinder nanostructure after heating. The resulting coacervates can release the micelles under physiological conditions in a zero‐order kinetics, possessing cargo proteins.
Takumi Egashira, Hiroshi Kamizawa, Yujiro Hamada, Wataru Fushimoto, Hiroshi Y. Yoshikawa, Yuji Higaki, Atsushi Takahara, Takeshi Mori, Yoshiki Katayama, Akihiro Kishimura   +9 more
wiley   +1 more source

Robust Bioconjugated Antigens Induce Immune Responses Preventing Malaria Infection and its Transmission

Small, EarlyView.
Engineered malaria antigens enable in vivo bioconjugation to submicron biopolymer particles in E. coli. Two antigens are co‐tethered at high density and defined stoichiometry. The resulting thermostable particles elicit strong, durable antibody and T‐cell responses, conferring robust protection and blocking mosquito transmission.
Nivethika Sivakumaran, Yevel Flores‐Garcia, Chanel M. Naar, Shuxiong Chen, Mili Mehta, Fijs W. B. van Leeuwen, Abhai Tripathi, Rajagopal Murugan, Meta Roestenberg, Fidel Zavala, Bernd H. A. Rehm   +10 more
wiley   +1 more source

Inter‐Crystal Spacing of Implantable Polymeric Surfaces as a Key Suppressor of Microbial Adhesion.

Small, EarlyView.
Biofilm formation on implantable devices is addressed by controlling inter‐crystal spacing in shape memory polymers. Repeated shape recovery aligns and enlarges crystalline phases and reduces amorphous regions, enhancing bacterial repellency. Three biofilm‐forming bacteria show reduced adhesion, and a one‐year dog bile‐duct model maintains function ...
Kang Suk Lee, Yohan Kim, Jueun Kim, Sungwoo Cho, Dae‐Hyun Kim, Hak‐Joon Sung   +5 more
wiley   +1 more source

Nearly a century of discoveries in bacterial genetics and their continuing impact on the field. [PDF]

Genetics
Baltrus DA, Merrikh H, Uecker H, Wong A.
europepmc   +2 more sources

A general and green approach of pH‐sensitive ZIF‐67 for encapsulating active substances

Smart Molecules, EarlyView.
Zeolitic imidazolate framework‐67 (ZIF‐67) was successfully synthesized in deionized water for 2 h in this work; meanwhile, various active substances could be encapsulated in one‐pot with the same process, resulting in high loading rates. The study delved into the growth mechanism, morphological difference and loading capacity.
Xinyi Sun, Yan Qi, Xinhao Che, Lulu Zhou, Yuxin Li, Lei Zhang, Jing Hu   +6 more
wiley   +1 more source

Crystal structure of the plant GABA aminotransferase AtGABA‐T from Arabidopsis thaliana

Acta Crystallographica Section F, EarlyView.
The crystal structure of A. thaliana γ‐aminobutyric acid aminotransferase (GABA‐T) reveals that plant GABA‐T belongs to the class III aminotransferase family and employs a C‐terminal arginine residue for γ‐aminobutyric acid recognition, in contrast to the N‐terminal arginine used by class II enzymes.γ‐Aminobutyric acid aminotransferase (GABA‐T) is a ...
Naofumi Okoda, Suguru Okuda, Kenta Tsutsumi, Hideaki Itoh, Ken Okamoto, Hiroshi Kawakami, Kaori Sano, Kenji Kobata, Koji Nagata   +8 more
wiley   +1 more source

Os estágios que constituem a história da pré-escrita: reflexões a partir dos experimentos realizados com crianças não alfabetizadas

Horizontes, 2013
Neste artigo apresentamos alguns dados da educação no solo da Revolução Russa de 1917 que contribuíram para o surgimento da teoria histórico-cultural, liderada por Vigostski e desenvolvida por um grupo de pesquisadores russos.
Fatima Aparecida de Souza Francioli
doaj  

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source