Results 131 to 140 of about 74,629 (302)

Binding capacity of luteinizing hormone-releasing hormone and its analogues for pituitary receptor sites

, 1977
Competition for luteinizing hormone-releasing hormone (LH-RH) receptor sites by the inhibitory analog [D-Phe 2, D-Trp 3, D-Phe 6]-LH-RH and by the superactive stimulatory analog [D-Trp 6]-LH-RH was observed in adenohypophysial homogenates incubated at 4 ...
Vilchez-Martinez, J.A, Arimura, A, Pedroza, E, Schally, A.V, Fishback, J   +4 more
core   +1 more source

Limited Clinical Impact of Androgen Receptor Repeat Length (CAG and GGC) in Klinefelter Syndrome: A Multivariable Analysis

Andrology, EarlyView.
ABSTRACT Background Klinefelter syndrome (KS) is characterized by marked phenotypic heterogeneity that might be influenced by genetic modifiers, including androgen receptor (AR) repeat length (CAGn and GGCn). The clinical relevance of these repeat lengths in patients with KS before testosterone replacement therapy (TRT) remains unclear.
Andrea Graziani, Alberto Scala, Maria Santa Rocca, Cinzia Vinanzi, Giuseppe Grande, Andrea Di Nisio, Riccardo Selice, Antonella Di Mambro, Alberto Ferlin   +8 more
wiley   +1 more source

Luteinizing hormone and follicle-stimulating hormone levels in extreme prematurity: Development of reference intervals

, 2008
OBJECTIVES. Establishing pediatric reference intervals has always been challenging, with most ranges used in pediatric laboratories developed over many years. The clinical interpretation of gonadotropins is important in the context of ambiguous genitalia.
Rodney Hunt (20020221), Angela Chiriano (20020224), Ronda Greaves (18044008), Margaret Zacharin (3419000)   +3 more
core  

Anosmin-1 modulates fibroblast growth factor receptor 1 signaling in human gonadotropin-releasing hormone olfactory neuroblasts through a heparan sulfate-dependent mechanism

, 2004
Defects of either anosmin-1 or fibroblast growth factor receptor 1 (FGFR1) are known to underlie hereditary Kallmann's syndrome (KS), a human disorder of olfactory and gonadotropin-releasing hormone (GnRH) neuronal ontogeny.
Guimond, S, Bouloux, PM, Turnbull, Jeremy, Turnbull, J, Hu, Youli, Kim, SH, Kim, Soo-Hyun, Schofield, Jonathan, Winyard, P, Winyard, Paul, Vannelli, GB, Bouloux, Pierre-Marc, Gonzalez-Martinez, D, Hu, YL, Schofield, J, Vannelli, Gabriella Barbara, González-Martínez, David, Guimond, Scott   +17 more
core   +1 more source

Association Between FTO rs1558902 Polymorphism, Age‐Related Hypogonadism, and Central Obesity in Japanese Men

Andrology, EarlyView.
ABSTRACT Background Obesity and low testosterone levels are closely interconnected, with the FTO gene being the most robust genetic determinant of body mass index (BMI). However, whether this primary genetic driver of obesity directly influences the hypothalamic‐pituitary‐testicular (HPT) axis remains unclear.
Takahiro Tsutsumi, Hideyuki Okuma, Fuminori Kazama, Masumi Endo, Yuna Takato, Hitomi Nara, Asako Miyazaki, Nozomi Harai, Kyoichiro Tsuchiya   +8 more
wiley   +1 more source

Radioimmunoassay for bovine luteinizing hormone (BLH)

, 1968
Recent progress in immunological techniques has revealed the possibility for more sensitive methods for assaying protein hormones. A radioimmunoassay technique has been developed for the detection and direct measurement of physiological levels of human ...
Chung, Pin-Kwen
core  

Search for novel therapies for triple negative breast cancers (TNBC): analogs of luteinizing hormone-releasing hormone (LHRH) and growth hormone-releasing hormone (GHRH)

, 2012
Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype that is clinically negative for the expression of estrogen and progesterone receptors (ER/PR) and human epidermal growth factor receptor-2 (HER2). Patients with TNBC have a worse
Block, Norman L, Perez, Roberto, Schally, Andrew V, Seitz, Stephan, Montero, Alberto, Buchholz, Stefan, Ortmann, Olaf, Engel, Jörg B   +7 more
core   +1 more source

Impact of FSHB and FSHR Genes Polymorphisms on Hormonal Profile and Sperm Retrieval Outcome in Men With Klinefelter Syndrome: A Clinical–Genetic Predictive Study

Andrology, EarlyView.
ABSTRACT Background Genetic variability within the follicle‐stimulating hormone (FSH)‐related genes might contribute to phenotypic heterogeneity in patients with Klinefelter syndrome (KS), yet its clinical impact on sperm retrieval remains unclear. Objectives To investigate the association between FSHB c.211 G > T and FSHR polymorphisms (c.2039 A > G ...
Andrea Graziani, Giuseppe Grande, Maria Santa Rocca, Massimo Iafrate, Riccardo Selice, Antonella Di Mambro, Alberto Ferlin   +6 more
wiley   +1 more source

Advanced glycation end products interfere in luteinizing hormone and follicle stimulating hormone signaling in human granulosa KGN cells

, 2017
Advanced glycation end products accumulate in the ovarian granulosa-cell layer of women with polycystic ovarian syndrome. Taken that the MAPK/ERK-pathway is a key regulator of oocyte maturation and function, consisting the main pathway used by the ...
Eleni A Kandaraki, Michael Koutsilieris, Christos Adamopoulos, Christina Piperi, Efstathia Papageorgiou, Evanthia Diamanti-Kandarakis, Athanasios G Papavassiliou, Antonios Chatzigeorgiou   +7 more
core   +1 more source

Loss‐of‐Function Variants in CCDC189 Cause Human Oligoasthenoteratozoospermia by Disrupting Sperm Flagellar and Acrosomal Architecture

Andrology, EarlyView.
ABSTRACT Background Oligoasthenoteratozoospermia (OAT), characterized by reduced sperm count, impaired motility, and abnormal morphology, is a major cause of male infertility with substantial genetic heterogeneity. However, the underlying genetic etiology remains unresolved in a large proportion of affected individuals.
Jianteng Zhou, Ghulam Mustafa, Tingting Lin, Jingwei Ye, Huan Zhang, Hanwei Jiang, Kexin Yang, Guoning Huang, Qinghua Shi   +8 more
wiley   +1 more source