Results 11 to 20 of about 149 (149)
Luteinizing hormone-releasing hormone antagonists [PDF]
Expert Opinion on Therapeutic Patents, 2009 Luteinizing hormone-releasing hormone (LH-RH) plays a central role in the vertebrate reproduction by regulating gonadal activity. Based on its binding to pituitary LH-RH receptors, as well as to LH-RH receptors expressed on cancer cells, LH-RH agonists and antagonists have been developed for different therapeutic applications.Here we give an overview ...
Mezö, Gábor, Manea, Marilena
openaire +4 more sources
Dose-Response relationship of luteinizing hormone to luteinizing hormone—releasing hormone in man [PDF]
Journal of Clinical Investigation, 1971 In previous clinical studies with highly purified porcine luteinizing hormone-releasing hormone (LH-RH), administration of the somewhat arbitrarily chosen doses of 700-1500 mug resulted in increased serum levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
Carlos Gual +5 more
openaire +3 more sources
Pituitary response to luteinizing hormone-releasing hormone in women with variant luteinizing hormone [PDF]
European Journal of Endocrinology, 2000 OBJECTIVE: To assess the LH response of the pituitary gland to GnRH stimulation in healthy women with a mutant beta-subunit (Trp8 to Arg8 and Ile15 to Thr15). DESIGN: Clinical study. PATIENTS: We studied 40 healthy non-pregnant Japanese women of known zygosity for the LH beta-subunit gene (3 homozygotes for the mutant gene, 17 heterozygotes, and 20 ...
Haruhiko Kanasaki +5 more
openaire +3 more sources
Luteinizing hormone in testicular descent [PDF]
Molecular and Cellular Endocrinology, 2007 A proper hypothalamus-pituitary-testis axis with normal androgen synthesis and action is a prerequisite for normal testicular descent. Various defects in this axis may result in cryptorchidism but endocrine abnormalities are rarely detected. Androgens regulate testicular descent but androgen action alone is not sufficient for normal testicular descent.
Toppari, Jorma +4 more
openaire +5 more sources
Response of Luteinizing Hormone and Follicle-Stimulating Hormone To Luteinizing Hormone Releasing Hormone in the Fetal Pig [PDF]
Biology of Reproduction, 1982 The responses of anesthetised fetal pigs (n=95) and chronically catheterized fetal pigs (n=10) to luteinizing hormone releasing hormone (LHRH) administration (2 micrograms/kg estimated fetal body weight) was investigated. Fetuses were studied at 55, 70, 85, 100, 106 (chronic) and 113 days. Plasma concentrations of follicle-stimulating hormone (FSH) and
N. Parvizi +4 more
openaire +3 more sources
Simultaneous Measurement of Luteinizing Hormone-releasing Hormone and Luteinizing Hormone during Estradiol-induced Luteinizing Hormone Surges in the Ovariectomized Ewe1 [PDF]
Biology of Reproduction, 1985 Sequential bleeding and push-pull perfusion of the hypothalamus were used to characterize luteinizing hormone (LH) and LH-releasing hormone (LHRH) release in ovariectomized (OVX) ewes after injection of corn oil or estradiol benzoate (EB). Push-pull cannulae were surgically implanted into the stalk median eminences of 24 OVX ewes.
L S Leshin +3 more
openaire +3 more sources
Journal of Dairy Science, 1986 The effects of 12 hourly 5-micrograms injections of luteinizing hormone-releasing hormone on luteinizing hormone release, were examined in 18 prepubertal Holstein heifers at 4, 7, or 10 mo of age. During a 6-h pretreatment period, mean serum luteinizing hormone concentrations and mean number of endogenous luteinizing hormone episodes per hour were not ...
R.D. Page, R.D. MacDonald
openaire +3 more sources
Luteinizing Hormone Receptors: Specific Binding of Human Luteinizing Hormone to Homogenates of Luteinized Rat Ovaries [PDF]
Proceedings of the National Academy of Sciences, 1972 Binding of human [ 125 I]luteinizing hormone to homogenates of luteinized rat ovaries is dependent upon time, temperature, and pH and is saturable. Injection of human chorionic gonadotropin in vivo or addition of unlabeled human chorionic gonadotropin or human or ovine luteinizing hormone
Robert J. Ryan, C. Y. Lee
openaire +3 more sources
Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations
Advanced Functional Materials, EarlyView.Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan +4 more
wiley +1 more source
Progress in Surface Plasmon and Other Resonance Biosensors for Biomedical Applications
Advanced Materials Technologies, EarlyView.This is the shortened version: Recent advancements in surface plasmon resonance and other optical resonance biosensors for biomedical applications are presented. Advanced sensing strategies are examined for the detection of diverse analytes, integration of nanomaterials and machine learning, and emerging nonplasmonic modes like guided mode resonance ...
Faten Bashar Kamal Eddin +8 more
wiley +1 more source