Results 51 to 60 of about 37,439 (280)

Luteolin [PDF]

Archiv der Pharmazie
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openaire   +2 more sources

Anti-allergic effect of luteolin in mice with allergic asthma and rhinitis

, 2017
Aim of the study : We aimed to evaluate the anti-allergic effect of luteolin treatment in mice with allergic asthma and rhinitis. Material and methods : Thirty-two BALB/c mice (n = 8 for each group) were used.
Jun-Ha Hwang, Dae-Young Kim, Young Hyo Kim, Tae Young Jang, Ah-Yeoun Jung, Tae-Suk Kyung   +5 more
core   +1 more source

A Blood‐Derived Double‐Network Hydrogel with Robust Wet Adhesion for Keratinized Mucosa Regeneration via Neutrophil Phenotype Reprogramming and Mechanophysical Niche Modulation

Advanced Science, EarlyView.
The iPRF‐MA/Alg‐NHS/Lut@EGCG (PGAE) double‐network hydrogel achieves durable wet adhesion in the oral environment. It simultaneously reprograms neutrophils from NETosis to phagocytosis for biofilm clearance, and activates the FAK‐RhoA‐YAP mechanotransduction pathway in gingival fibroblasts to drive extracellular matrix remodeling, thereby promoting ...
Sicong Ren, Xinting Yang, Jingxia Chen, Yihan Wang, Jian Feng, Jing Zhou, Jiaxin Luo, Jingjie Zhai, Quan Lin, Yanmin Zhou   +9 more
wiley   +1 more source

β-Cyclodextrin metal-organic framework as a green carrier to improve the dissolution, bioavailability, and liver protective effect of luteolin

International Journal of Pharmaceutics: X
The incidence of acetaminophen-induced liver injury has increased, but effective prevention methods are limited. Although luteolin has hepatoprotective activity, its low solubility and bioavailability limit its applications.
Dan Yang, Min Zhao, Yihe Huang, Liwen Chen, Jiqin Fang, Jiaonan Liu, Miao Wang, Chunjie Zhao   +7 more
doaj   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Network pharmacology and experimental verification-based strategy for exploring the mechanisms of luteolin in the treatment of osteosarcoma

Cancer Cell International, 2023
Background Luteolin is an active ingredient in various traditional Chinese medicines for the treatment of multiple tumors. However, the mechanisms of its inhibitory effect on osteosarcoma proliferation and metastasis remain unclear.
Renxuan Huang, Mingxian Xu, Weitang Guo, Mingzhe Cheng, Rui Dong, Jian Tu, Shao Xu, Changye Zou   +7 more
doaj   +1 more source

XLIX.—Luteolin. Part II [PDF]

J. Chem. Soc., Trans., 1896
n ...
openaire   +2 more sources

Mechanistic investigation of Liujing Toutong tablet in the treatment of cerebral ischemia–reperfusion injury in rats by the integration of serum pharmacochemistry and metabolomics

Animal Models and Experimental Medicine, EarlyView.
The research strategy for pharmacodynamics, serum pharmacochemistry, metabolomics, and network pharmacology analysis method in intervention effects of LTT are illustrated. Abstract Background Liujing Toutong tablet (LTT) is a traditional Chinese patent medicine.
Zihan Yu, Ke Pei, Xiulin Wang, Wenling Li, Hongchang Li, Wangyang Xie, Xianglong Meng, Tingting Zhao, Yan Ning, Haixin Liu, Wenbin He   +10 more
wiley   +1 more source

Luteolin induces carcinoma cell apoptosis through binding Hsp90 to suppress constitutive activation of STAT3. [PDF]

PLoS ONE, 2012
BACKGROUND: Abnormal activity of STAT3 is associated with a number of human malignancies. Hsp90 plays a central role in stabilizing newly synthesized proteins and participates in maintaining the functional competency of a number of signaling transducers ...
Jin Fu, Dan Chen, Bo Zhao, Zhihui Zhao, Jiahong Zhou, Yimiao Xu, Yinqiang Xin, Chang Liu, Lan Luo, Zhimin Yin   +9 more
doaj   +1 more source

Luteolin inhibits triple-negative breast cancer by inducing apoptosis and autophagy through SGK1-FOXO3a-BNIP3 signaling

Frontiers in Pharmacology, 2023
Background: Triple-negative breast cancer (TNBC) is one of the most prominent neoplasm disorders and lacks efficacious treatments yet. Luteolin (3′,4′,5,7-tetrahydroxyflavone), a natural flavonoid commonly presented in plants, has been reported to delay ...
Ling Wu, Ling Wu, Yingda Lin, Songyu Gao, Yongfang Wang, Huiji Pan, Zhaozhi Wang, Marina Pozzolini, Fengling Yang, Haiyan Zhang, Yi Yang, Liang Xiao, Yuan Xu   +12 more
doaj   +1 more source