Results 81 to 90 of about 10,548 (182)

Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model

The Journal of Physiology, EarlyView.
Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley   +1 more source

Transcatheter Left Ventricular Restoration in Ischemic Heart Failure and Dilated Cardiomyopathy

Catheterization and Cardiovascular Interventions, Volume 107, Issue 4, Page 898-908, March 1, 2026.
ABSTRACT Ischemic heart disease is the leading global cause of death and frequently progresses to ischemic heart failure (IHF) after myocardial infarction through adverse left ventricular (LV)remodeling. Surgical LV restoration improves ventricular geometry and function but is limited by invasiveness and inconsistent outcomes.
Muhammad Mohid Haroon, Faizan Ahmad, Ramsha Ali, Saqlain Haider, Areehah Zafar Masood, Usama Yaseen, Taha Ahmad Zaka Ur Rehman, Muhammad Abdullah Sardar, Muhammad Umer, Shruthi Aswathappa, Muhammad Salman Sabri, Muhammad Muneeb Murtaza, Rubiya Ali, Sunny Kumar, Sameer Ali, Najam Gohar, Mohamed Bakr, Swapnil Patel, Mohammad A. Hussain, Fawaz Alenezi   +19 more
wiley   +1 more source

Implantable devices: a bridge to heart transplantation

Вестник трансплантологии и искусственных органов, 2019
Terminal stage heart failure represents a substantial worldwide problem for the healthcare system. Despite significant improvements (medical heart failure treatment, implantable cardioverters, cardiac resynchronization devices), long-term survival and ...
D. Zimpfer, D. Wiedemann, A. Neissner
doaj   +1 more source

From Thrombolysis to Transplant: Navigating the Storm of Delayed STEMI and Cardiogenic Shock

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Delayed STEMI presentation can cause extensive myocardial necrosis, left ventricular thrombus, cardiogenic shock, and progression to end‐stage heart failure despite reperfusion. Early recognition and timely transfer to specialized shock centers are critical.
Syed Rafay Hussain Zaidi, Muhammad Sheraz Hameed, Muhammad Ahsan, Hamza Ishfaq, Ali Iqbal, Azka Mirza, Sadia Rekhum, Muhammad Sohaib Alvi, Muhammad Usama Naveed   +8 more
wiley   +1 more source

Cohort Study to Determine the Impact of CYP3A5 Genotype on Tacrolimus Dosing Requirements and Trough Concentrations in Heart Transplant Recipients

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 3, March 2026.
ABSTRACT Background Tacrolimus is primarily metabolized by Cytochrome P450 (CYP)3A4/5. The Clinical Pharmacogenetics Implementation Consortium recommends increasing the initial dose 1.5‐ to 2‐fold in CYP3A5 expressers to enhance transplant outcomes. Our objective was to investigate the impact of CYP3A5 expresser status on tacrolimus dosing requirements
Yanting Wu, Michael T. Eadon, Laurie Schenkelberg, Roopa A. Rao, Todd C. Skaar, Emma M. Tillman, Tyler Shugg   +6 more
wiley   +1 more source

Pre-Implant Immune Status is Associated with Infection Risk After Left Ventricular Assist Device Implantation

Journal of Inflammation Research
Maja-Theresa Dieterlen,* Eva Katharina Messer,* Kristin Klaeske, Franz Sieg, Sandra Eifert, Josephina Haunschild, Khalil Jawad, Diyar Saeed, Alexey Dashkevich,* Michael Andrew Borger* University Clinic of Cardiac Surgery, Leipzig Heart ...
Dieterlen MT, Messer EK, Klaeske K, Sieg F, Eifert S, Haunschild J, Jawad K, Saeed D, Dashkevich A, Borger MA   +9 more
doaj  

Alms1 KO Rat: A New Model of Cardiometabolic Syndrome With Spontaneous Hypertension

Acta Physiologica, Volume 242, Issue 3, March 2026.
ABSTRACT Alström syndrome 1 (ALMS1) is a protein linked to Alström syndrome, a rare genetic disorder characterized by obesity, insulin resistance, hyperinsulinemia, and hypertension. Genetic studies have further associated Alms1 with hypertension in human populations. However, the precise mechanisms by which ALMS1 regulates metabolic and cardiovascular
Ankita B. Jaykumar, Sumit R. Monu, Jiang Xu, Mariela Mendez, Xiao‐Ping Yang, Nour‐Eddine Rhaleb, Pablo A. Ortiz   +6 more
wiley   +1 more source

Impact of Prolonged Impella 5.5 Support on Post‐Transplant Outcomes: An Institutional Study

Clinical Transplantation, Volume 40, Issue 3, March 2026.
ABSTRACT Objectives Microaxial flow pump devices are utilized as a bridge to heart transplantation for patients in advanced cardiogenic shock. Little is known about the impact of device duration on post‐transplant outcomes. This study aims to compare post‐transplantation outcomes based on duration of support with the Impella 5.5.
David Rekhtman, Amit Iyengar, Cindy Song, Michaela Asher, Max Shin, Michael Catalano, Omar Toubat, Emma Morganroth, Alyson Brown, Joyce Wald, Aditya Parikh, Mauer Biscotti, Marisa Cevasco   +12 more
wiley   +1 more source

Incidence and Risk Factors of Limb Ischaemia in Adult Patients Receiving Veno‐Arterial Extracorporeal Membrane Oxygenation: A Systematic Review and Meta‐Analysis

Nursing in Critical Care, Volume 31, Issue 2, March 2026.
ABSTRACT Background Limb ischaemia is a serious and potentially limb‐threatening vascular complication associated with veno‐arterial extracorporeal membrane oxygenation (V‐A ECMO). However, substantial heterogeneity has been observed in the reported incidence rates and identified risk factors among published studies.
Meiqian Guo, Mengyao Ji, Jiayuan Qu, Chuanxiang Yuan, Peixi Wang   +4 more
wiley   +1 more source

Eligibility for Anti‐Amyloid‐β Monoclonal Antibodies in Patients With Primary Progressive Aphasia due to Alzheimer's Disease in Japan

Psychogeriatrics, Volume 26, Issue 2, March 2026.
ABSTRACT Background Primary progressive aphasia (PPA) is a clinical syndrome characterized by progressive language impairment. The logopenic variant (lvPPA) is frequently associated with Alzheimer's disease (AD) pathology. With the approval of anti‐amyloid‐β monoclonal antibodies, such as lecanemab and donanemab, for the treatment of AD, accurately ...
Shoya Inagawa, Yuta Inagawa, Akito Tsugawa, Naoto Takenoshita, Kazuhiro Saito, Kenji Ishii, Kensaku Kasuga, Takeshi Ikeuchi, Soichiro Shimizu   +8 more
wiley   +1 more source