Results 51 to 60 of about 29,286 (285)

Genome Analysis of a Novel Polysaccharide-Degrading Bacterium Paenibacillus algicola and Determination of Alginate Lyases

Marine Drugs, 2022
Carbohydrate-active enzymes (CAZymes) are an important characteristic of bacteria in marine systems. We herein describe the CAZymes of Paenibacillus algicola HB172198T, a novel type species isolated from brown algae in Qishui Bay, Hainan, China.
Huiqin Huang, Zhiguo Zheng, Xiaoxiao Zou, Zixu Wang, Rong Gao, Jun Zhu, Yonghua Hu, Shixiang Bao   +7 more
doaj   +1 more source

Cloning and characterization of a pectin lyase gene from Colletotrichum lindemuthianum and comparative phylogenetic/structural analyses with genes from phytopathogenic and saprophytic/opportunistic microorganisms

BMC Microbiology, 2011
Background Microorganisms produce cell-wall-degrading enzymes as part of their strategies for plant invasion/nutrition. Among these, pectin lyases (PNLs) catalyze the depolymerization of esterified pectin by a β-elimination mechanism.
Lara-Márquez Alicia, Zavala-Páramo María G, López-Romero Everardo, Calderón-Cortés Nancy, López-Gómez Rodolfo, Conejo-Saucedo Ulises, Cano-Camacho Horacio   +6 more
doaj   +1 more source

What lies on macroalgal surface: diversity of polysaccharide degraders in culturable epiphytic bacteria

AMB Express, 2022
Keypoints Macroalgae are source of bacterial polysaccharidases for blue biotechnologies. Amilases, pectinases, alginate lyases and agarases were widespread among isolates. Hydrolytic profile correlates to strain phylogeny, host species, isolation medium.
Marta Barbato, Violetta Vacchini, Aschwin H. Engelen, Giovanni Patania, Francesca Mapelli, Sara Borin, Elena Crotti   +6 more
doaj   +1 more source

A novel ATP dependent dimethylsulfoniopropionate lyase in bacteria that releases dimethyl sulfide and acryloyl-CoA

eLife, 2021
Dimethylsulfoniopropionate (DMSP) is an abundant and ubiquitous organosulfur molecule in marine environments with important roles in global sulfur and nutrient cycling.
Chun-Yang Li, Xiu-Juan Wang, Xiu-Lan Chen, Qi Sheng, Shan Zhang, Peng Wang, Mussa Quareshy, Branko Rihtman, Xuan Shao, Chao Gao, Fuchuan Li, Shengying Li, Weipeng Zhang, Xiao-Hua Zhang, Gui-Peng Yang, Jonathan D Todd, Yin Chen, Yu-Zhong Zhang   +17 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Alginate-modifying enzymes: Biological roles and biotechnological uses

Frontiers in Microbiology, 2015
Alginate denotes a group of industrially important 1-4-linked biopolymers composed of the C-5-epimers β-D-mannuronic acid (M) and α-L-guluronic acid (G).
Helga eErtesvåg
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Functional Characterization of Carbohydrate-Binding Modules in a New Alginate Lyase, TsAly7B, from Thalassomonas sp. LD5

Marine Drugs, 2019
Alginate lyases degrade alginate into oligosaccharides, of which the biological activities have vital roles in various fields. Some alginate lyases contain one or more carbohydrate-binding modules (CBMs), which assist the function of the catalytic ...
Zhelun Zhang, Luyao Tang, Mengmeng Bao, Zhigang Liu, Wengong Yu, Feng Han   +5 more
doaj   +1 more source

Mechanistic insight into acrylate metabolism and detoxification in marine dimethylsulfoniopropionate-catabolizing bacteria [PDF]

, 2017
Dimethylsulfoniopropionate (DMSP) cleavage, yielding dimethyl sulfide (DMS) and acrylate, provides vital carbon sources to marine bacteria, is a key component of the global sulfur cycle and effects atmospheric chemistry and potentially climate.
Adams, Alcolombri, Archer, Asao, Baldwin, Biebl, Brummett, Brummett, Clayden, Conti, Curson, Curson, Curson, Curson, Ducruix, Elssner, Emsley, Gulick, Gulick, Herrmann, Hisanaga, Horswill, Jackson, Jogl, Khare, Kiene, Kiene, Kirkwood, Kochan, Kubota, Kuchta, Li, Li, Malmstrom, Marahiel, Marc, Matsumoto, Persson, Petursdottir, Potterton, Rajashekhara, Reger, Reisch, Reisch, Sato, Schiebel, Schnicker, Seeliger, Seymour, Sievert, Simo, Souza, Sullivan, Sulzenbacher, Sun, Tapiolas, Todd, Todd, Vandecandelaere, Wang, Wang, Yoch, Zhou   +62 more
core   +1 more source