Results 31 to 40 of about 5,629 (171)

Safety considerations of gene‐based therapies for Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract Gene‐based therapies show increasing promise for the treatment of neurologic disease. In 2016, nusinersen, an RNA‐based therapy, was approved for children with spinal muscular atrophy (SMA). Over 200 clinical trials have utilized gene therapy approaches for a host of neurodegenerative and neuromuscular disorders, including Alzheimer's disease (
Elizabeth A. Bevins, Gabriel C. Léger, Michelle A. Herman, John M. Ringman, Subhojit Roy, Matthew Shtrahman, Judy Pa, Howard H. Feldman   +7 more
wiley   +1 more source

Urgent natural foci infections transmitted by ticks in Saint-Petersburg

Журнал инфектологии, 2018
Purpose: to conduct a comparative analysis and to identify the epidemiological and clinical features of tick-borne encephalitis (TBE) and Lyme borreliosis as a mono- and coinfections in St. Petersburg. Materials and methods.
V. V. Nechaev, A. A. Yakovlev, A. N. Uskov, L. E. Boburina, N. V. Lavrova, M. N. Pogromskaya, B. I. Aslanov, A. O. Shapar, S. V. Pavlenko, L. N. Pozhidaeva, A. K. Ivanov, A. I. Kravtsova, S. A. Leppik, E. I. Vitovich, M. I. Fedunyak   +14 more
doaj   +1 more source

HEMOGRAM INDICATORS ASSESSMENT FOR EARLY PREDICTING THE MIXED INFECTION OF THE ERYTHEMA MIGRANS FORM OF LYME BORRELIOSIS AND TICK-BORNE ENCEPHALITIS

Siberian Journal of Life Sciences and Agriculture, 2023
Background. It is difficult to confirm the diagnosis of the mixed infection of the erythema migrans form of Lyme borreliosis and tick-borne encephalitis at the onset of the disease because of delayed seroconversion. Purpose.
Ekaterina N. Ilyinskikh, Evgenia N. Filatova, Alina V. Reshetova   +2 more
doaj   +1 more source

Mapping Zoonotic Risk With a Biogeographic Perspective on Transmission Cycles

Journal of Biogeography, Volume 53, Issue 7, July 2026.
ABSTRACT Aim When mapping the transmission risk of zoonotic diseases, the way vectors and wild carrier hosts are integrated into the modelling process has relevant impacts on the final output. The wide diversity of zoonotic cycles entails that a single methodological approach may be insufficient to cover the influence of vectors and wild carrier hosts ...
Jesús Olivero, Marina Cobos‐Mayo, Alisa Aliaga‐Samanez   +2 more
wiley   +1 more source

Lyme borreliosis in Europe [PDF]

Eurosurveillance, 2011
Despite improvements in prevention, diagnosis and treatment, Lyme borreliosis (LB) is still the most common arthropod-borne disease in temperate regions of the northern hemisphere, with risk of infection associated with occupation (e.g. forestry work) and certain outdoor recreational activities (e.g. mushroom collecting).
Rizzoli, Annapaola, Hauffe, Heidi Christine, Carpi, Giovanna, Vourc'h G. I., Neteler, Markus Georg, Rosa', Roberto   +5 more
openaire   +4 more sources

The Laboratory Diagnosis of Lyme Borreliosis: Guidelines from the Canadian Public Health Laboratory Network

Canadian Journal of Infectious Diseases and Medical Microbiology, 2007
Lyme borreliosis is uncommonly seen in Canada. Most cases have occurred in close proximity to small geographical areas where infected ticks have become established. Although few cases are seen, thousands of patients are tested yearly. Unless patients are
Canadian Public Health Laboratory Network
doaj   +1 more source

Clinical-epidemiologycal characteric of tick neuroinfections at children

Бюллетень сибирской медицины, 2006
Piculiarities of tick-borne encefalitis and Lyme borreliosis at children in Tomsk region have been stadid from 1990—2004. Characte- ristiks of clinical forms of tick-borne in acute period at 264 children and 224 children Lyme borreliosis in acute period ...
A. P. Pomogaeva, M. O. Karavaeva, O. V. Obidina   +2 more
doaj   +1 more source

Risk Factors for Tick‐Borne Diseases in Germany: A Scoping Review

Zoonoses and Public Health, Volume 73, Issue 4, Page 297-313, June 2026.
ABSTRACT Tick‐borne diseases (TBDs) have proliferated in Germany. The two most prevalent TBDs, Lyme‐borreliosis and tick‐borne encephalitis, can present with nonspecific symptoms and lead to serious neurological complications. To date, a review synthesising the risk factors of acquiring a TBD in Germany is missing.
Carolin Schlupp, Matthias Hans Belau
wiley   +1 more source

Borrelia burgdorferi sensu lato Employs Several Escape Mechanisms to Bypass the Human Defense System

European Journal of Immunology, Volume 56, Issue 5, May 2026.
Integrated overview of host defense and immune evasion in Lyme Borreliosis. Bbsl evades immunity through tick saliva‐mediated suppression of innate defenses, TLR2/NOD2‐driven cytokine dysregulation, and interference with JAK/STAT and CIITA‐dependent antigen presentation.
Zara Karami, Hadewych J. M. ter Hofstede, Leo A. B. Joosten   +2 more
wiley   +1 more source

The cost of Lyme borreliosis [PDF]

European Journal of Public Health, 2017
Abstract Background: Lyme borreliosis (LB) is the most frequently reported tick-borne infection in Europe and North America. The aim of this study was to estimate the cost-of-illness of LB in the Netherlands. Methods: We used available incidence estimates from 2010 for tick bite consultations and three symptomatic LB outcomes: erythema ...
van den Wijngaard, Cees C, Hofhuis, Agnetha, Wong, Albert, Harms, Margriet G, de Wit, G Ardine, Lugnér, Anna K, Suijkerbuijk, Anita W M, Mangen, Marie-Josée J, van Pelt, Wilfrid   +8 more
openaire   +3 more sources